Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme

Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme

The aim of this research was to formulate oleogel with thyme essential oil with potential antimicrobial activity, design optimal formulation, and evaluate the influence of ingredients on texture parameters of preparation. Central composite design was applied to statistical optimization of colloidal...

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Main Authors: Giedre Kasparaviciene, Zenona Kalveniene, Alvydas Pavilonis, Ruta Marksiene, Jurgita Dauksiene, Jurga Bernatoniene
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2018/9431819
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spelling doaj-d37c244bda2548a8be02cf6a5c260de32020-11-24T22:22:34ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882018-01-01201810.1155/2018/94318199431819Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of ThymeGiedre Kasparaviciene0Zenona Kalveniene1Alvydas Pavilonis2Ruta Marksiene3Jurgita Dauksiene4Jurga Bernatoniene5Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, LithuaniaDepartment of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, LithuaniaInstitute of Microbiology and Virology, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50161 Kaunas, LithuaniaDepartment of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, LithuaniaDepartment of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, LithuaniaDepartment of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, LithuaniaThe aim of this research was to formulate oleogel with thyme essential oil with potential antimicrobial activity, design optimal formulation, and evaluate the influence of ingredients on texture parameters of preparation. Central composite design was applied to statistical optimization of colloidal silica and paraffin oil mixture for the modeling of oleogel delivery system. The influence of designed formulations on response variables (texture parameters), firmness, cohesiveness, consistency, and index of viscosity, was evaluated. Quality of essential oil of thyme was assessed by determinate concentration of thymol and carvacrol using gas chromatography with flame ionization detection (GC-FID). Microbiological tests have shown that oleogel with thyme essential oil affects Candida albicans microorganism when thyme essential oil’s concentration is 0,05% in oleogel mixture.http://dx.doi.org/10.1155/2018/9431819
collection DOAJ
language English
format Article
sources DOAJ
author Giedre Kasparaviciene
Zenona Kalveniene
Alvydas Pavilonis
Ruta Marksiene
Jurgita Dauksiene
Jurga Bernatoniene
spellingShingle Giedre Kasparaviciene
Zenona Kalveniene
Alvydas Pavilonis
Ruta Marksiene
Jurgita Dauksiene
Jurga Bernatoniene
Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme
Evidence-Based Complementary and Alternative Medicine
author_facet Giedre Kasparaviciene
Zenona Kalveniene
Alvydas Pavilonis
Ruta Marksiene
Jurgita Dauksiene
Jurga Bernatoniene
author_sort Giedre Kasparaviciene
title Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme
title_short Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme
title_full Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme
title_fullStr Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme
title_full_unstemmed Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme
title_sort formulation and characterization of potential antifungal oleogel with essential oil of thyme
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2018-01-01
description The aim of this research was to formulate oleogel with thyme essential oil with potential antimicrobial activity, design optimal formulation, and evaluate the influence of ingredients on texture parameters of preparation. Central composite design was applied to statistical optimization of colloidal silica and paraffin oil mixture for the modeling of oleogel delivery system. The influence of designed formulations on response variables (texture parameters), firmness, cohesiveness, consistency, and index of viscosity, was evaluated. Quality of essential oil of thyme was assessed by determinate concentration of thymol and carvacrol using gas chromatography with flame ionization detection (GC-FID). Microbiological tests have shown that oleogel with thyme essential oil affects Candida albicans microorganism when thyme essential oil’s concentration is 0,05% in oleogel mixture.
url http://dx.doi.org/10.1155/2018/9431819
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AT zenonakalveniene formulationandcharacterizationofpotentialantifungaloleogelwithessentialoilofthyme
AT alvydaspavilonis formulationandcharacterizationofpotentialantifungaloleogelwithessentialoilofthyme
AT rutamarksiene formulationandcharacterizationofpotentialantifungaloleogelwithessentialoilofthyme
AT jurgitadauksiene formulationandcharacterizationofpotentialantifungaloleogelwithessentialoilofthyme
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