Sexual Dimorphism of Corticosteroid Signaling during Kidney Development
Sexual dimorphism involves differences between biological sexes that go beyond sexual characteristics. In mammals, differences between sexes have been demonstrated regarding various biological processes, including blood pressure and predisposition to develop hypertension early in adulthood, which ma...
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doaj-d382e1af4ee44f638eaf3db507d7843d2021-06-01T00:18:34ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01225275527510.3390/ijms22105275Sexual Dimorphism of Corticosteroid Signaling during Kidney DevelopmentMargaux Laulhé0Laurence Dumeige1Thi An Vu2Imene Hani3Eric Pussard4Marc Lombès5Say Viengchareun6Laetitia Martinerie7Université Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, FranceUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, FranceUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, FranceUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, FranceUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, FranceUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, FranceUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, FranceUniversité Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, CEDEX, 94276 Le Kremlin-Bicêtre, FranceSexual dimorphism involves differences between biological sexes that go beyond sexual characteristics. In mammals, differences between sexes have been demonstrated regarding various biological processes, including blood pressure and predisposition to develop hypertension early in adulthood, which may rely on early events during development and in the neonatal period. Recent studies suggest that corticosteroid signaling pathways (comprising glucocorticoid and mineralocorticoid signaling pathways) have distinct tissue-specific expression and regulation during this specific temporal window in a sex-dependent manner, most notably in the kidney. This review outlines the evidence for a gender differential expression and activation of renal corticosteroid signaling pathways in the mammalian fetus and neonate, from mouse to human, that may favor mineralocorticoid signaling in females and glucocorticoid signaling in males. Determining the effects of such differences may shed light on short term and long term pathophysiological consequences, markedly for males.https://www.mdpi.com/1422-0067/22/10/5275aldosteronecortisolmineralocorticoid and glucocorticoid receptorsneonateskidneydevelopment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Margaux Laulhé Laurence Dumeige Thi An Vu Imene Hani Eric Pussard Marc Lombès Say Viengchareun Laetitia Martinerie |
spellingShingle |
Margaux Laulhé Laurence Dumeige Thi An Vu Imene Hani Eric Pussard Marc Lombès Say Viengchareun Laetitia Martinerie Sexual Dimorphism of Corticosteroid Signaling during Kidney Development International Journal of Molecular Sciences aldosterone cortisol mineralocorticoid and glucocorticoid receptors neonates kidney development |
author_facet |
Margaux Laulhé Laurence Dumeige Thi An Vu Imene Hani Eric Pussard Marc Lombès Say Viengchareun Laetitia Martinerie |
author_sort |
Margaux Laulhé |
title |
Sexual Dimorphism of Corticosteroid Signaling during Kidney Development |
title_short |
Sexual Dimorphism of Corticosteroid Signaling during Kidney Development |
title_full |
Sexual Dimorphism of Corticosteroid Signaling during Kidney Development |
title_fullStr |
Sexual Dimorphism of Corticosteroid Signaling during Kidney Development |
title_full_unstemmed |
Sexual Dimorphism of Corticosteroid Signaling during Kidney Development |
title_sort |
sexual dimorphism of corticosteroid signaling during kidney development |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-05-01 |
description |
Sexual dimorphism involves differences between biological sexes that go beyond sexual characteristics. In mammals, differences between sexes have been demonstrated regarding various biological processes, including blood pressure and predisposition to develop hypertension early in adulthood, which may rely on early events during development and in the neonatal period. Recent studies suggest that corticosteroid signaling pathways (comprising glucocorticoid and mineralocorticoid signaling pathways) have distinct tissue-specific expression and regulation during this specific temporal window in a sex-dependent manner, most notably in the kidney. This review outlines the evidence for a gender differential expression and activation of renal corticosteroid signaling pathways in the mammalian fetus and neonate, from mouse to human, that may favor mineralocorticoid signaling in females and glucocorticoid signaling in males. Determining the effects of such differences may shed light on short term and long term pathophysiological consequences, markedly for males. |
topic |
aldosterone cortisol mineralocorticoid and glucocorticoid receptors neonates kidney development |
url |
https://www.mdpi.com/1422-0067/22/10/5275 |
work_keys_str_mv |
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1721415270729252864 |