PENGARUH EKSTRAK KOPI ROBUSTA TERHADAP EKSPRESI OSTEOKALSIN PADA OSTEOBLAS SELAMA PERGERAKAN GIGI ORTODONTI

• Main Author: Herniyati Herniyati
• Format: Article
• Language: English
• Published: Universitas Gadjah Mada 2017-08-01
• Series: Jurnal Teknosains: Jurnal Ilmiah Sains dan Teknologi
• Subjects: Alveolar bone remodeling; Orthodontic tooth movement; Osteocalcin; Robusta coffee
• Online Access: https://jurnal.ugm.ac.id/teknosains/article/view/23158

The objective of  research is  to determine the expression of osteocalcin on osteoblasts during orthodontic tooth movement after administration robusta coffee extract. Materials and Methods: 16 rats  were divided into 2 groups: group K: rats applied with orthodontic mechanical force (OMF) and  group P: OMF +  coffee robusta extract of 20mg /100 g of BW. OMF was conducted by applying  ligature wire on permanent maxillary right first molar and both permanent maxillary incisivus. Subsequently, the permanent maxillary right first molar  moved to mesial with Ni-Ti orthodontic closed coil spring. Observations were made on day 15 by immunohistochemical examination to determine the expression of osteocalcin. Results: Robusta coffee extract  improved the expression of osteocalcin in the compression and tension areas (p <0.05). Expression of osteocalcin in  tension area  larger than that in compression area (p <0.05). Conclusion: The administration of Robusta coffee extract  increases the expression of osteocalcin, which can increase alveolar bone remodeling.