Reduction by the positive allosteric modulator of the GABA<sub>B</sub> receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure
The present study was designed to evaluate (a) alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP) rats exposed to the so-called “sipper” procedure (characterized by the temporal separation between alcohol-seeking and -taking phases), and (...
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doaj-d39ba341c29e479bad90e950ce18a3792020-11-24T22:32:28ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402010-07-01110.3389/fpsyt.2010.000202012Reduction by the positive allosteric modulator of the GABA<sub>B</sub> receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedurePaola Maccioni0Paolo Flore1Mauro A M Carai2Claudia Mugnaini3Serena Pasquini4Federico Corelli5Gian Luigi Gessa6Giancarlo Colombo7Consiglio Nazionale delle Ricerche Neuroscience InstituteUniversity of CagliariConsiglio Nazionale delle Ricerche Neuroscience InstituteUniversity of SienaUniversity of SienaUniversity of SienaConsiglio Nazionale delle Ricerche Neuroscience InstituteConsiglio Nazionale delle Ricerche Neuroscience InstituteThe present study was designed to evaluate (a) alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP) rats exposed to the so-called “sipper” procedure (characterized by the temporal separation between alcohol-seeking and -taking phases), and (b) the effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in sP rats exposed to this procedure. To this end, sP rats were initially trained to lever-respond under a reinforcement requirement (RR) 55 (RR55) for alcohol. Achievement of RR55 resulted in the 20-min presentation of the alcohol (15%, v/v)-containing sipper bottle. Once stable levels of lever-responding and alcohol consumption were reached, rats were treated with 0, 25, 50, and 100 mg/kg GS39783 (i.g.) 60 min before the self-administration session. Rats displayed robust alcohol-seeking (as suggested by relatively short latencies to the first lever-response and high frequencies of lever-responding) and -taking (as suggested by alcohol intakes averaging approximately 1.5 g/kg) behaviors. Pretreatment with GS39783 inhibited both alcohol-seeking (the number of rats achieving RR55 and the mean RR value were virtually halved) and -taking (the amount of self-administered alcohol was reduced by approximately 60%). The results of the present study suggest the power of the “sipper” procedure in triggering high levels of alcohol-seeking and -taking behavior in sP rats. Further, these results extend to this additional procedure of alcohol self-administration the capacity of GS39783 to reduce the motivational properties of alcohol and alcohol consumption in sP rats.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2010.00020/fullsipper procedure of alcohol self-administrationalcohol-seeking and -taking behaviorGS39783positive allosteric modulator of the GABAB receptorSardinian alcohol-preferring (sP) rats |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paola Maccioni Paolo Flore Mauro A M Carai Claudia Mugnaini Serena Pasquini Federico Corelli Gian Luigi Gessa Giancarlo Colombo |
spellingShingle |
Paola Maccioni Paolo Flore Mauro A M Carai Claudia Mugnaini Serena Pasquini Federico Corelli Gian Luigi Gessa Giancarlo Colombo Reduction by the positive allosteric modulator of the GABA<sub>B</sub> receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure Frontiers in Psychiatry sipper procedure of alcohol self-administration alcohol-seeking and -taking behavior GS39783 positive allosteric modulator of the GABAB receptor Sardinian alcohol-preferring (sP) rats |
author_facet |
Paola Maccioni Paolo Flore Mauro A M Carai Claudia Mugnaini Serena Pasquini Federico Corelli Gian Luigi Gessa Giancarlo Colombo |
author_sort |
Paola Maccioni |
title |
Reduction by the positive allosteric modulator of the GABA<sub>B</sub> receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure |
title_short |
Reduction by the positive allosteric modulator of the GABA<sub>B</sub> receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure |
title_full |
Reduction by the positive allosteric modulator of the GABA<sub>B</sub> receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure |
title_fullStr |
Reduction by the positive allosteric modulator of the GABA<sub>B</sub> receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure |
title_full_unstemmed |
Reduction by the positive allosteric modulator of the GABA<sub>B</sub> receptor, GS39783, of alcohol self-administration in Sardinian alcohol-preferring rats exposed to the “sipper” procedure |
title_sort |
reduction by the positive allosteric modulator of the gaba<sub>b</sub> receptor, gs39783, of alcohol self-administration in sardinian alcohol-preferring rats exposed to the “sipper” procedure |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2010-07-01 |
description |
The present study was designed to evaluate (a) alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP) rats exposed to the so-called “sipper” procedure (characterized by the temporal separation between alcohol-seeking and -taking phases), and (b) the effect of the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in sP rats exposed to this procedure. To this end, sP rats were initially trained to lever-respond under a reinforcement requirement (RR) 55 (RR55) for alcohol. Achievement of RR55 resulted in the 20-min presentation of the alcohol (15%, v/v)-containing sipper bottle. Once stable levels of lever-responding and alcohol consumption were reached, rats were treated with 0, 25, 50, and 100 mg/kg GS39783 (i.g.) 60 min before the self-administration session. Rats displayed robust alcohol-seeking (as suggested by relatively short latencies to the first lever-response and high frequencies of lever-responding) and -taking (as suggested by alcohol intakes averaging approximately 1.5 g/kg) behaviors. Pretreatment with GS39783 inhibited both alcohol-seeking (the number of rats achieving RR55 and the mean RR value were virtually halved) and -taking (the amount of self-administered alcohol was reduced by approximately 60%). The results of the present study suggest the power of the “sipper” procedure in triggering high levels of alcohol-seeking and -taking behavior in sP rats. Further, these results extend to this additional procedure of alcohol self-administration the capacity of GS39783 to reduce the motivational properties of alcohol and alcohol consumption in sP rats. |
topic |
sipper procedure of alcohol self-administration alcohol-seeking and -taking behavior GS39783 positive allosteric modulator of the GABAB receptor Sardinian alcohol-preferring (sP) rats |
url |
http://journal.frontiersin.org/Journal/10.3389/fpsyt.2010.00020/full |
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