Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors
Abstract To present the feasibility of a dynamic whole-body (DWB) 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors (WD-NETs). Sixty-one patients who underwent a DWB 68Ga-DOTATOC-PET/CT for a histologically proven/highly suspected WD-NET were prospectively in...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-03-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-021-83965-9 |
id |
doaj-d39da825f175412f822a6780af2476cf |
---|---|
record_format |
Article |
spelling |
doaj-d39da825f175412f822a6780af2476cf2021-03-11T12:24:06ZengNature Publishing GroupScientific Reports2045-23222021-03-0111111510.1038/s41598-021-83965-9Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumorsPhilippe Thuillier0David Bourhis1Jean Philippe Metges2Romain Le Pennec3Karim Amrane4Ulrike Schick5Frédérique Blanc-Beguin6Simon Hennebicq7Pierre-Yves Salaun8Véronique Kerlan9Nicolas Karakatsanis10Ronan Abgral11Department of Endocrinology, University Hospital of BrestEA GETBO 3878, University Hospital of BrestDepartment of Oncology, University Hospital of BrestEA GETBO 3878, University Hospital of BrestDepartment of Radiotherapy, University Hospital of BrestDepartment of Radiotherapy, University Hospital of BrestEA GETBO 3878, University Hospital of BrestEA GETBO 3878, University Hospital of BrestEA GETBO 3878, University Hospital of BrestDepartment of Endocrinology, University Hospital of BrestDepartment of Radiology, Weil Cornell Medical College of Cornell UniversityEA GETBO 3878, University Hospital of BrestAbstract To present the feasibility of a dynamic whole-body (DWB) 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors (WD-NETs). Sixty-one patients who underwent a DWB 68Ga-DOTATOC-PET/CT for a histologically proven/highly suspected WD-NET were prospectively included. The acquisition consisted in single-bed dynamic acquisition centered on the heart, followed by the DWB and static acquisitions. For liver, spleen and tumor (1–5/patient), Ki values (in ml/min/100 ml) were calculated according to Patlak's analysis and tumor-to-liver (TLR-Ki) and tumor-to-spleen ratios (TSR-Ki) were recorded. Ki-based parameters were compared to static parameters (SUVmax/SUVmean, TLR/TSRmean, according to liver/spleen SUVmean), in the whole-cohort and according to the PET system (analog/digital). A correlation analysis between SUVmean/Ki was performed using linear and non-linear regressions. Ki-liver was not influenced by the PET system used, unlike SUVmax/SUVmean. The regression analysis showed a non-linear relation between Ki/SUVmean (R2 = 0.55,0.68 and 0.71 for liver, spleen and tumor uptake, respectively) and a linear relation between TLRmean/TLR-Ki (R2 = 0.75). These results were not affected by the PET system, on the contrary of the relation between TSRmean/TSR-Ki (R2 = 0.94 and 0.73 using linear and non-linear regressions in digital and analog systems, respectively). Our study is the first showing the feasibility of a DWB 68Ga-DOTATOC-PET/CT acquisition in WD-NETs.https://doi.org/10.1038/s41598-021-83965-9 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Philippe Thuillier David Bourhis Jean Philippe Metges Romain Le Pennec Karim Amrane Ulrike Schick Frédérique Blanc-Beguin Simon Hennebicq Pierre-Yves Salaun Véronique Kerlan Nicolas Karakatsanis Ronan Abgral |
spellingShingle |
Philippe Thuillier David Bourhis Jean Philippe Metges Romain Le Pennec Karim Amrane Ulrike Schick Frédérique Blanc-Beguin Simon Hennebicq Pierre-Yves Salaun Véronique Kerlan Nicolas Karakatsanis Ronan Abgral Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors Scientific Reports |
author_facet |
Philippe Thuillier David Bourhis Jean Philippe Metges Romain Le Pennec Karim Amrane Ulrike Schick Frédérique Blanc-Beguin Simon Hennebicq Pierre-Yves Salaun Véronique Kerlan Nicolas Karakatsanis Ronan Abgral |
author_sort |
Philippe Thuillier |
title |
Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors |
title_short |
Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors |
title_full |
Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors |
title_fullStr |
Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors |
title_full_unstemmed |
Prospective study of dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors |
title_sort |
prospective study of dynamic whole-body 68ga-dotatoc-pet/ct acquisition in patients with well-differentiated neuroendocrine tumors |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-03-01 |
description |
Abstract To present the feasibility of a dynamic whole-body (DWB) 68Ga-DOTATOC-PET/CT acquisition in patients with well-differentiated neuroendocrine tumors (WD-NETs). Sixty-one patients who underwent a DWB 68Ga-DOTATOC-PET/CT for a histologically proven/highly suspected WD-NET were prospectively included. The acquisition consisted in single-bed dynamic acquisition centered on the heart, followed by the DWB and static acquisitions. For liver, spleen and tumor (1–5/patient), Ki values (in ml/min/100 ml) were calculated according to Patlak's analysis and tumor-to-liver (TLR-Ki) and tumor-to-spleen ratios (TSR-Ki) were recorded. Ki-based parameters were compared to static parameters (SUVmax/SUVmean, TLR/TSRmean, according to liver/spleen SUVmean), in the whole-cohort and according to the PET system (analog/digital). A correlation analysis between SUVmean/Ki was performed using linear and non-linear regressions. Ki-liver was not influenced by the PET system used, unlike SUVmax/SUVmean. The regression analysis showed a non-linear relation between Ki/SUVmean (R2 = 0.55,0.68 and 0.71 for liver, spleen and tumor uptake, respectively) and a linear relation between TLRmean/TLR-Ki (R2 = 0.75). These results were not affected by the PET system, on the contrary of the relation between TSRmean/TSR-Ki (R2 = 0.94 and 0.73 using linear and non-linear regressions in digital and analog systems, respectively). Our study is the first showing the feasibility of a DWB 68Ga-DOTATOC-PET/CT acquisition in WD-NETs. |
url |
https://doi.org/10.1038/s41598-021-83965-9 |
work_keys_str_mv |
AT philippethuillier prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT davidbourhis prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT jeanphilippemetges prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT romainlepennec prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT karimamrane prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT ulrikeschick prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT frederiqueblancbeguin prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT simonhennebicq prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT pierreyvessalaun prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT veroniquekerlan prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT nicolaskarakatsanis prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors AT ronanabgral prospectivestudyofdynamicwholebody68gadotatocpetctacquisitioninpatientswithwelldifferentiatedneuroendocrinetumors |
_version_ |
1724224297920102400 |