BRCA1 and BRCA2 mutation spectrum – an update on mutation distribution in a large cancer genetics clinic in Norway

BRCA1 and BRCA2 mutation spectrum – an update on mutation distribution in a large cancer genetics clinic in Norway

Abstract Background Founder mutations in the two breast cancer genes, BRCA1 and BRCA2, have been described in many populations, among these are Ashkenazi-Jewish, Polish, Norwegian and Icelandic. Founder mutation testing in patients with relevant ancestry has been a cost-efficient approach in such po...

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Bibliographic Details
Main Authors: Cecilie Heramb, Teresia Wangensteen, Eli Marie Grindedal, Sarah Louise Ariansen, Sheba Lothe, Ketil Riddervold Heimdal, Lovise Mæhle
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Hereditary Cancer in Clinical Practice
Subjects:
BRCA1
BRCA2
Founder mutations
Genetic testing
Online Access:http://link.springer.com/article/10.1186/s13053-017-0085-6

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http://link.springer.com/article/10.1186/s13053-017-0085-6

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