SARS-CoV-2 viral load is associated with increased disease severity and mortality
In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflam...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19057-5 |
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doaj-d3b04d9a629f44488b9f26c98ed75ef02021-05-11T08:11:13ZengNature Publishing GroupNature Communications2041-17232020-10-011111910.1038/s41467-020-19057-5SARS-CoV-2 viral load is associated with increased disease severity and mortalityJesse Fajnzylber0James Regan1Kendyll Coxen2Heather Corry3Colline Wong4Alexandra Rosenthal5Daniel Worrall6Francoise Giguel7Alicja Piechocka-Trocha8Caroline Atyeo9Stephanie Fischinger10Andrew Chan11Keith T. Flaherty12Kathryn Hall13Michael Dougan14Edward T. Ryan15Elizabeth Gillespie16Rida Chishti17Yijia Li18Nikolaus Jilg19Dusan Hanidziar20Rebecca M. Baron21Lindsey Baden22Athe M. Tsibris23Katrina A. Armstrong24Daniel R. Kuritzkes25Galit Alter26Bruce D. Walker27Xu Yu28Jonathan Z. Li29The Massachusetts Consortium for Pathogen ReadinessBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolRagon Institute of MGH, MIT and Harvard, Harvard Medical SchoolMassachusetts General Hospital, Harvard Medical SchoolRagon Institute of MGH, MIT and Harvard, Harvard Medical SchoolRagon Institute of MGH, MIT and Harvard, Harvard Medical SchoolRagon Institute of MGH, MIT and Harvard, Harvard Medical SchoolMassachusetts General Hospital, Harvard Medical SchoolMassachusetts General Hospital, Harvard Medical SchoolMassachusetts General Hospital, Harvard Medical SchoolMassachusetts General Hospital, Harvard Medical SchoolMassachusetts General Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolMassachusetts General Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolMassachusetts General Hospital, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolRagon Institute of MGH, MIT and Harvard, Harvard Medical SchoolRagon Institute of MGH, MIT and Harvard, Harvard Medical SchoolRagon Institute of MGH, MIT and Harvard, Harvard Medical SchoolBrigham and Women’s Hospital, Harvard Medical SchoolIn this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death.https://doi.org/10.1038/s41467-020-19057-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jesse Fajnzylber James Regan Kendyll Coxen Heather Corry Colline Wong Alexandra Rosenthal Daniel Worrall Francoise Giguel Alicja Piechocka-Trocha Caroline Atyeo Stephanie Fischinger Andrew Chan Keith T. Flaherty Kathryn Hall Michael Dougan Edward T. Ryan Elizabeth Gillespie Rida Chishti Yijia Li Nikolaus Jilg Dusan Hanidziar Rebecca M. Baron Lindsey Baden Athe M. Tsibris Katrina A. Armstrong Daniel R. Kuritzkes Galit Alter Bruce D. Walker Xu Yu Jonathan Z. Li The Massachusetts Consortium for Pathogen Readiness |
| spellingShingle |
Jesse Fajnzylber James Regan Kendyll Coxen Heather Corry Colline Wong Alexandra Rosenthal Daniel Worrall Francoise Giguel Alicja Piechocka-Trocha Caroline Atyeo Stephanie Fischinger Andrew Chan Keith T. Flaherty Kathryn Hall Michael Dougan Edward T. Ryan Elizabeth Gillespie Rida Chishti Yijia Li Nikolaus Jilg Dusan Hanidziar Rebecca M. Baron Lindsey Baden Athe M. Tsibris Katrina A. Armstrong Daniel R. Kuritzkes Galit Alter Bruce D. Walker Xu Yu Jonathan Z. Li The Massachusetts Consortium for Pathogen Readiness SARS-CoV-2 viral load is associated with increased disease severity and mortality Nature Communications |
| author_facet |
Jesse Fajnzylber James Regan Kendyll Coxen Heather Corry Colline Wong Alexandra Rosenthal Daniel Worrall Francoise Giguel Alicja Piechocka-Trocha Caroline Atyeo Stephanie Fischinger Andrew Chan Keith T. Flaherty Kathryn Hall Michael Dougan Edward T. Ryan Elizabeth Gillespie Rida Chishti Yijia Li Nikolaus Jilg Dusan Hanidziar Rebecca M. Baron Lindsey Baden Athe M. Tsibris Katrina A. Armstrong Daniel R. Kuritzkes Galit Alter Bruce D. Walker Xu Yu Jonathan Z. Li The Massachusetts Consortium for Pathogen Readiness |
| author_sort |
Jesse Fajnzylber |
| title |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_short |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_full |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_fullStr |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_full_unstemmed |
SARS-CoV-2 viral load is associated with increased disease severity and mortality |
| title_sort |
sars-cov-2 viral load is associated with increased disease severity and mortality |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-10-01 |
| description |
In this study, Massachusetts Consortium for Pathogen Readiness (MassCPR) investigators assess the relationship between SARS-CoV-2 viral load and COVID-19 disease severity and report that the levels of detectable viral RNA, especially in plasma, correlates with severity of respiratory disease, inflammatory markers and predicted risk of death. |
| url |
https://doi.org/10.1038/s41467-020-19057-5 |
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