SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES

SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES

In the present study, a series of 2-(4´-Substitutedanilinosydnon-3´-yl)-1, 3, 4-thiadiazino (6, 5-b) indoles 7a-j have been synthesized. All the synthesized compounds have been characterized by elemental and spectral (I R, 1H- NMR and Mass) spectrometric analysis. Furthermore, above mentioned compou...

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Bibliographic Details
Main Authors: Hemant Panwar, Shishupal Singh, Nidhi Chaudhary
Format: Article
Language:English
Published: Universitas Gadjah Mada 2011-12-01
Series:Indonesian Journal of Chemistry
Subjects:
Indoles
Antifungal
Antibacterial
Acute toxicity
Online Access:https://jurnal.ugm.ac.id/ijc/article/view/21380
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spelling doaj-d3c3f1fc0c6b487a8e1e12a0bc9b3edb2020-11-25T00:03:26ZengUniversitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782011-12-0111320120610.22146/ijc.2138014478SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLESHemant Panwar0Shishupal Singh1Nidhi Chaudhary2Depatment of Chemistry, Neelkanth Institute of Technology, Modipuram-250110, Meerut, U.P.Department of Chemistry, Aligarh Muslim University, Aligarh-202002, U.P.Department of Chemistry, I.I.M.T., I.E.T., Ganga Nagar, Meerut-250001, U.P.In the present study, a series of 2-(4´-Substitutedanilinosydnon-3´-yl)-1, 3, 4-thiadiazino (6, 5-b) indoles 7a-j have been synthesized. All the synthesized compounds have been characterized by elemental and spectral (I R, 1H- NMR and Mass) spectrometric analysis. Furthermore, above mentioned compounds were evaluated for their antibacterial and antifungal activities against selected panel of pathogenic strains. Ampicillin trihydrate, ofloxacin and fluconazole, griseofulvin were used as standard drugs for antibacterial and anifungal activity respectively. Compound 7j was found the most potent one with lesser toxicity in the prepared indole derivatives.https://jurnal.ugm.ac.id/ijc/article/view/21380IndolesAntifungalAntibacterialAcute toxicity
collection DOAJ
language English
format Article
sources DOAJ
author Hemant Panwar
Shishupal Singh
Nidhi Chaudhary
spellingShingle Hemant Panwar
Shishupal Singh
Nidhi Chaudhary
SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES
Indonesian Journal of Chemistry
Indoles
Antifungal
Antibacterial
Acute toxicity
author_facet Hemant Panwar
Shishupal Singh
Nidhi Chaudhary
author_sort Hemant Panwar
title SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES
title_short SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES
title_full SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES
title_fullStr SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES
title_full_unstemmed SYDNONE DERIVATIVES A SYNTHONS FOR NOVEL MESOIONIC COMPOUNDS. SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SOME 2-(4`-SUBSTITUTED ANILINOSYNDON-3`-YL)-1, 3, 4-THIADIAZINO (6, 5-B) INDOLES
title_sort sydnone derivatives a synthons for novel mesoionic compounds. synthesis, characterization and antimicrobial evaluation of some 2-(4`-substituted anilinosyndon-3`-yl)-1, 3, 4-thiadiazino (6, 5-b) indoles
publisher Universitas Gadjah Mada
series Indonesian Journal of Chemistry
issn 1411-9420
2460-1578
publishDate 2011-12-01
description In the present study, a series of 2-(4´-Substitutedanilinosydnon-3´-yl)-1, 3, 4-thiadiazino (6, 5-b) indoles 7a-j have been synthesized. All the synthesized compounds have been characterized by elemental and spectral (I R, 1H- NMR and Mass) spectrometric analysis. Furthermore, above mentioned compounds were evaluated for their antibacterial and antifungal activities against selected panel of pathogenic strains. Ampicillin trihydrate, ofloxacin and fluconazole, griseofulvin were used as standard drugs for antibacterial and anifungal activity respectively. Compound 7j was found the most potent one with lesser toxicity in the prepared indole derivatives.
topic Indoles
Antifungal
Antibacterial
Acute toxicity
url https://jurnal.ugm.ac.id/ijc/article/view/21380
work_keys_str_mv AT hemantpanwar sydnonederivativesasynthonsfornovelmesoioniccompoundssynthesischaracterizationandantimicrobialevaluationofsome24substitutedanilinosyndon3yl134thiadiazino65bindoles
AT shishupalsingh sydnonederivativesasynthonsfornovelmesoioniccompoundssynthesischaracterizationandantimicrobialevaluationofsome24substitutedanilinosyndon3yl134thiadiazino65bindoles
AT nidhichaudhary sydnonederivativesasynthonsfornovelmesoioniccompoundssynthesischaracterizationandantimicrobialevaluationofsome24substitutedanilinosyndon3yl134thiadiazino65bindoles
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