Perspectives on the Genetic Associations of Ankylosing Spondylitis

Perspectives on the Genetic Associations of Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a common form of inflammatory spinal arthritis with a complex polygenic aetiology. Genome-wide association studies have identified more than 100 loci, including some involved in antigen presentation (HLA-B27, ERAP1, and ERAP2), some in Th17 responses (IL6R, IL23R, TYK2...

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Bibliographic Details
Main Authors: B. Paul Wordsworth, Carla J. Cohen, Connor Davidson, Matteo Vecellio
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
epigenetics
aetiology
pathogenesis
spondyloarthropathy
interleukin-23
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.603726/full

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