Genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: A review of the literature

Introduction: Odontogenic lesions are diverse and varied. Some of them, in addition to having a significant power of bone destruction, recur most often after surgical removal. This could be explained by moleculoskeletal mechanisms that have not yet been mastered. Hence the initiation of the present...

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Main Authors: Mamadou Diatta, Macoura Gadji, Babacar Tamba, Marie Jeo Dièmè, Bintou Catherine Gassama, Mouhammad Kane, Soukeye Dia Tine
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Advances in Oral and Maxillofacial Surgery
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667147621001151
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spelling doaj-d3c872ff54d2460e8fc823de7fb35dd82021-08-06T04:23:13ZengElsevierAdvances in Oral and Maxillofacial Surgery2667-14762021-07-013100128Genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: A review of the literatureMamadou Diatta0Macoura Gadji1Babacar Tamba2Marie Jeo Dièmè3Bintou Catherine Gassama4Mouhammad Kane5Soukeye Dia Tine6Oral Surgery Service, Department of Odontology, Cheikh Anta Diop University of Dakar (UCAD), Senegal; Corresponding author. Institute of Odontology and Stomatology / Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University of Dakar, Box 5005, Dakar Fann, Senegal.Molecular Biology Service, Department of Pharmacy, Cheikh Anta Diop University of Dakar (UCAD), SenegalOral Surgery Service, Department of Odontology, Cheikh Anta Diop University of Dakar (UCAD), SenegalPathological Anatomy Service, Department of Medicine, Cheikh Anta Diop University of Dakar (UCAD), SenegalOral Surgery Service, Department of Odontology, Cheikh Anta Diop University of Dakar (UCAD), SenegalOral Surgery Service, Department of Odontology, Cheikh Anta Diop University of Dakar (UCAD), SenegalOral Surgery Service, Department of Odontology, Cheikh Anta Diop University of Dakar (UCAD), SenegalIntroduction: Odontogenic lesions are diverse and varied. Some of them, in addition to having a significant power of bone destruction, recur most often after surgical removal. This could be explained by moleculoskeletal mechanisms that have not yet been mastered. Hence the initiation of the present work whose objective was to study the genetic and malecular anomalies of maxillo-mandibular odontogenic cysts and benign tumours by a review of the literature. Material and method: Search engines such as Pubmed, PMC, Google Scholar, Science direct, Journal of oncology were searched using key words with some filters. Results: Out of a total of 162 articles consulted, 40 were retained. The analysis of the articles retrieved allowed us to gather the genetic and molecular anomalies involved in the pathogenesis and development of benign maxillomandibular odontogenic cysts and tumours, sometimes explaining the clinical behaviour of some of these lesions. In addition to the molecular and genetic alterations encountered in the key genes of odontogenesis, molecules inhibiting the activities of apoptosis proteins would be hyper-expressed in certain very aggressive odontogenic lesions with a recurrence capacity. Conclusion: Knowledge of the molecular mechanisms involved in the pathogenesis and development of odontogenic lesions would allow the use of new therapeutic procedures in management of maxillo-mandibular odontogenic lesions.http://www.sciencedirect.com/science/article/pii/S2667147621001151Odontogenic cystsBenign odontogenic tumoursBiomarkerGenetic anomaliesMolecular anomalies
collection DOAJ
language English
format Article
sources DOAJ
author Mamadou Diatta
Macoura Gadji
Babacar Tamba
Marie Jeo Dièmè
Bintou Catherine Gassama
Mouhammad Kane
Soukeye Dia Tine
spellingShingle Mamadou Diatta
Macoura Gadji
Babacar Tamba
Marie Jeo Dièmè
Bintou Catherine Gassama
Mouhammad Kane
Soukeye Dia Tine
Genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: A review of the literature
Advances in Oral and Maxillofacial Surgery
Odontogenic cysts
Benign odontogenic tumours
Biomarker
Genetic anomalies
Molecular anomalies
author_facet Mamadou Diatta
Macoura Gadji
Babacar Tamba
Marie Jeo Dièmè
Bintou Catherine Gassama
Mouhammad Kane
Soukeye Dia Tine
author_sort Mamadou Diatta
title Genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: A review of the literature
title_short Genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: A review of the literature
title_full Genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: A review of the literature
title_fullStr Genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: A review of the literature
title_full_unstemmed Genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: A review of the literature
title_sort genetic and molecular abnormalities in benign maxillomandibular odontogenic cysts and tumours: a review of the literature
publisher Elsevier
series Advances in Oral and Maxillofacial Surgery
issn 2667-1476
publishDate 2021-07-01
description Introduction: Odontogenic lesions are diverse and varied. Some of them, in addition to having a significant power of bone destruction, recur most often after surgical removal. This could be explained by moleculoskeletal mechanisms that have not yet been mastered. Hence the initiation of the present work whose objective was to study the genetic and malecular anomalies of maxillo-mandibular odontogenic cysts and benign tumours by a review of the literature. Material and method: Search engines such as Pubmed, PMC, Google Scholar, Science direct, Journal of oncology were searched using key words with some filters. Results: Out of a total of 162 articles consulted, 40 were retained. The analysis of the articles retrieved allowed us to gather the genetic and molecular anomalies involved in the pathogenesis and development of benign maxillomandibular odontogenic cysts and tumours, sometimes explaining the clinical behaviour of some of these lesions. In addition to the molecular and genetic alterations encountered in the key genes of odontogenesis, molecules inhibiting the activities of apoptosis proteins would be hyper-expressed in certain very aggressive odontogenic lesions with a recurrence capacity. Conclusion: Knowledge of the molecular mechanisms involved in the pathogenesis and development of odontogenic lesions would allow the use of new therapeutic procedures in management of maxillo-mandibular odontogenic lesions.
topic Odontogenic cysts
Benign odontogenic tumours
Biomarker
Genetic anomalies
Molecular anomalies
url http://www.sciencedirect.com/science/article/pii/S2667147621001151
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