Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation

Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation

Adenovirus (ADV) can cause significant morbidity and mortality in children following haematopoietic stem cell transplantation (HSCT), with an incidence of up to 27% and notable associated morbidity and mortality. T-cell depleted grafts and severe lymphopenia are major risk factors for the developmen...

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Main Authors: Winnie WY Ip, Waseem Qasim
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Advances in Hematology
Online Access:http://dx.doi.org/10.1155/2013/176418
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spelling doaj-d3d0a062e35d4a4d88fc6462c2ec05da2021-07-02T07:15:14ZengHindawi LimitedAdvances in Hematology1687-91041687-91122013-01-01201310.1155/2013/176418176418Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell TransplantationWinnie WY Ip0Waseem Qasim1Molecular Immunology Unit, UCL Institute of Child Health, 30 Guildford Street, London WC1N 1EH, UKMolecular Immunology Unit, UCL Institute of Child Health, 30 Guildford Street, London WC1N 1EH, UKAdenovirus (ADV) can cause significant morbidity and mortality in children following haematopoietic stem cell transplantation (HSCT), with an incidence of up to 27% and notable associated morbidity and mortality. T-cell depleted grafts and severe lymphopenia are major risk factors for the development of adenovirus disease after HSCT. Current antiviral treatments are at best virostatic and may have significant side effects. Adoptive transfer of donor-derived virus-specific T cells has been shown to be an effective strategy for the prevention and treatment of ADV infection after HSCT. Here we review progress in the field and present a pathway for the management of adenovirus in the posttransplant setting.http://dx.doi.org/10.1155/2013/176418
collection DOAJ
language English
format Article
sources DOAJ
author Winnie WY Ip
Waseem Qasim
spellingShingle Winnie WY Ip
Waseem Qasim
Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation
Advances in Hematology
author_facet Winnie WY Ip
Waseem Qasim
author_sort Winnie WY Ip
title Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation
title_short Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation
title_full Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation
title_fullStr Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation
title_full_unstemmed Management of Adenovirus in Children after Allogeneic Hematopoietic Stem Cell Transplantation
title_sort management of adenovirus in children after allogeneic hematopoietic stem cell transplantation
publisher Hindawi Limited
series Advances in Hematology
issn 1687-9104
1687-9112
publishDate 2013-01-01
description Adenovirus (ADV) can cause significant morbidity and mortality in children following haematopoietic stem cell transplantation (HSCT), with an incidence of up to 27% and notable associated morbidity and mortality. T-cell depleted grafts and severe lymphopenia are major risk factors for the development of adenovirus disease after HSCT. Current antiviral treatments are at best virostatic and may have significant side effects. Adoptive transfer of donor-derived virus-specific T cells has been shown to be an effective strategy for the prevention and treatment of ADV infection after HSCT. Here we review progress in the field and present a pathway for the management of adenovirus in the posttransplant setting.
url http://dx.doi.org/10.1155/2013/176418
work_keys_str_mv AT winniewyip managementofadenovirusinchildrenafterallogeneichematopoieticstemcelltransplantation
AT waseemqasim managementofadenovirusinchildrenafterallogeneichematopoieticstemcelltransplantation
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