Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis
The role of interleukin-13 in mediating ulcerative colitis remains under scrutiny. Compelling evidence from both man and mouse suggests that IL-13 not only contributes to the pathology associated with disease but is also involved in mediating the inflammatory response. These studies have led to the...
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2018-11-01
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doaj-d3d1ac113a1443bf8ade8796f46856762020-11-24T22:12:50ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882018-11-01810.3389/fcimb.2018.00395406380Targeting IL-13 as a Host-Directed Therapy Against Ulcerative ColitisJ. Claire HovingThe role of interleukin-13 in mediating ulcerative colitis remains under scrutiny. Compelling evidence from both man and mouse suggests that IL-13 not only contributes to the pathology associated with disease but is also involved in mediating the inflammatory response. These studies have led to the approach of targeting IL-13 as a promising treatment strategy in alleviating ulcerative colitis disease. Despite this evidence, recent clinical trial data suggests that specifically blocking the receptor through which IL-13 signals, IL-4 receptor-alpha (IL-4Rα) in ulcerative colitis patients, is insufficient in protecting them from disease outcome. This challenges the importance of IL-13 as a therapeutic target. This review describes the role of IL-13 in ulcerative colitis and current treatment strategies that target IL-13. The potential role of IL-13 signaling independently of IL-4Rα in mediating ulcerative colitis is highlighted as an important consideration when targeting the signaling mechanisms of IL-13 for therapeutic approaches.https://www.frontiersin.org/article/10.3389/fcimb.2018.00395/fullulcerative colitisinterleukin-13IL-4 receptor-alphadrug targetsInflammatory Bowel DiseaseT-helper type 2 immune response |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
J. Claire Hoving |
spellingShingle |
J. Claire Hoving Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis Frontiers in Cellular and Infection Microbiology ulcerative colitis interleukin-13 IL-4 receptor-alpha drug targets Inflammatory Bowel Disease T-helper type 2 immune response |
author_facet |
J. Claire Hoving |
author_sort |
J. Claire Hoving |
title |
Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis |
title_short |
Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis |
title_full |
Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis |
title_fullStr |
Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis |
title_full_unstemmed |
Targeting IL-13 as a Host-Directed Therapy Against Ulcerative Colitis |
title_sort |
targeting il-13 as a host-directed therapy against ulcerative colitis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2018-11-01 |
description |
The role of interleukin-13 in mediating ulcerative colitis remains under scrutiny. Compelling evidence from both man and mouse suggests that IL-13 not only contributes to the pathology associated with disease but is also involved in mediating the inflammatory response. These studies have led to the approach of targeting IL-13 as a promising treatment strategy in alleviating ulcerative colitis disease. Despite this evidence, recent clinical trial data suggests that specifically blocking the receptor through which IL-13 signals, IL-4 receptor-alpha (IL-4Rα) in ulcerative colitis patients, is insufficient in protecting them from disease outcome. This challenges the importance of IL-13 as a therapeutic target. This review describes the role of IL-13 in ulcerative colitis and current treatment strategies that target IL-13. The potential role of IL-13 signaling independently of IL-4Rα in mediating ulcerative colitis is highlighted as an important consideration when targeting the signaling mechanisms of IL-13 for therapeutic approaches. |
topic |
ulcerative colitis interleukin-13 IL-4 receptor-alpha drug targets Inflammatory Bowel Disease T-helper type 2 immune response |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2018.00395/full |
work_keys_str_mv |
AT jclairehoving targetingil13asahostdirectedtherapyagainstulcerativecolitis |
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