Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma
Purpose: Oligoprogression, defined as limited sites of progression on systemic therapy, in patients with metastatic renal cell carcinoma (mRCC) is not uncommon, possibly because of inter- and intratumoral heterogeneity. We evaluated the effect of stereotactic ablative radiation therapy (SAbR) for lo...
Main Authors: | , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-09-01
|
Series: | Advances in Radiation Oncology |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2452109421000506 |
id |
doaj-d3d6725df09840e68eee2bfa7aa552b3 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonathan E. Schoenhals, BS Osama Mohamad, MD, PhD Alana Christie, MS Yuanyuan Zhang, MD, PhD Daniel Li, MD Nirmish Singla, MD, MSCS Isaac Bowman, MD Waddah Arafat, MD Hans Hammers, MD Kevin Courtney, MD, PhD Suzanne Cole, MD Aditya Bagrodia, MD Vitaly Margulis, MD Neil Desai, MD Aurelie Garant, MD Hak Choy, MD Robert Timmerman, MD James Brugarolas, MD, PhD Raquibul Hannan, MD, PhD |
spellingShingle |
Jonathan E. Schoenhals, BS Osama Mohamad, MD, PhD Alana Christie, MS Yuanyuan Zhang, MD, PhD Daniel Li, MD Nirmish Singla, MD, MSCS Isaac Bowman, MD Waddah Arafat, MD Hans Hammers, MD Kevin Courtney, MD, PhD Suzanne Cole, MD Aditya Bagrodia, MD Vitaly Margulis, MD Neil Desai, MD Aurelie Garant, MD Hak Choy, MD Robert Timmerman, MD James Brugarolas, MD, PhD Raquibul Hannan, MD, PhD Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma Advances in Radiation Oncology |
author_facet |
Jonathan E. Schoenhals, BS Osama Mohamad, MD, PhD Alana Christie, MS Yuanyuan Zhang, MD, PhD Daniel Li, MD Nirmish Singla, MD, MSCS Isaac Bowman, MD Waddah Arafat, MD Hans Hammers, MD Kevin Courtney, MD, PhD Suzanne Cole, MD Aditya Bagrodia, MD Vitaly Margulis, MD Neil Desai, MD Aurelie Garant, MD Hak Choy, MD Robert Timmerman, MD James Brugarolas, MD, PhD Raquibul Hannan, MD, PhD |
author_sort |
Jonathan E. Schoenhals, BS |
title |
Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma |
title_short |
Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma |
title_full |
Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma |
title_fullStr |
Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma |
title_full_unstemmed |
Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell Carcinoma |
title_sort |
stereotactic ablative radiation therapy for oligoprogressive renal cell carcinoma |
publisher |
Elsevier |
series |
Advances in Radiation Oncology |
issn |
2452-1094 |
publishDate |
2021-09-01 |
description |
Purpose: Oligoprogression, defined as limited sites of progression on systemic therapy, in patients with metastatic renal cell carcinoma (mRCC) is not uncommon, possibly because of inter- and intratumoral heterogeneity. We evaluated the effect of stereotactic ablative radiation therapy (SAbR) for longitudinal control of oligoprogressive mRCC. Methods and Materials: Patients with extracranial mRCC were included in this retrospective analysis if they progressed in ≤3 sites on systemic therapy while demonstrating response/stability at other sites and received SAbR to all progressing sites without switching systemic therapy. Our primary endpoint was modified progression-free survival (mPFS), which we calculated from the start of SAbR to the start of a subsequent systemic therapy, death, or loss to follow-up. Results: We identified 36 patients with a median follow-up of 20.4 months (interquartile range, 10.9-29.4). Forty-three sites were treated with SAbR with a median dose of 36 Gy (range, 18-50) in 3 fractions (range, 1-5). Median time to SAbR from the start of systemic therapy was 11.4 months (interquartile range, 6.1-17.1). Median mPFS was 9.2 months (95% confidence interval [CI], 5.9-13.2). Patients receiving SAbR while on immunotherapy exhibited a longer median mPFS (>28.4 months, log-rank P = .0001) than patients not on immunotherapy (9.2 months). Median overall survival from SAbR administration was 43.4 months (95% CI, 21.5-not Reached). The 1-year local control rate was 93% (95% CI, 78.7-97.5). Most SAbR-related toxicities were grade 1 to 2 (33% of patients), with one grade 5 hemoptysis event possibly related to SAbR or disease progression. Conclusions: SAbR has the potential to extend the the duration of current systemic therapy for selected patients with mRCC, preserving subsequent therapies for later administration possibly enabling longer treatment duration. |
url |
http://www.sciencedirect.com/science/article/pii/S2452109421000506 |
work_keys_str_mv |
AT jonathaneschoenhalsbs stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT osamamohamadmdphd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT alanachristiems stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT yuanyuanzhangmdphd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT daniellimd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT nirmishsinglamdmscs stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT isaacbowmanmd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT waddaharafatmd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT hanshammersmd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT kevincourtneymdphd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT suzannecolemd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT adityabagrodiamd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT vitalymargulismd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT neildesaimd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT aureliegarantmd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT hakchoymd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT roberttimmermanmd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT jamesbrugarolasmdphd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma AT raquibulhannanmdphd stereotacticablativeradiationtherapyforoligoprogressiverenalcellcarcinoma |
_version_ |
1716862198831120384 |
spelling |
doaj-d3d6725df09840e68eee2bfa7aa552b32021-10-01T05:06:20ZengElsevierAdvances in Radiation Oncology2452-10942021-09-0165100692Stereotactic Ablative Radiation Therapy for Oligoprogressive Renal Cell CarcinomaJonathan E. Schoenhals, BS0Osama Mohamad, MD, PhD1Alana Christie, MS2Yuanyuan Zhang, MD, PhD3Daniel Li, MD4Nirmish Singla, MD, MSCS5Isaac Bowman, MD6Waddah Arafat, MD7Hans Hammers, MD8Kevin Courtney, MD, PhD9Suzanne Cole, MD10Aditya Bagrodia, MD11Vitaly Margulis, MD12Neil Desai, MD13Aurelie Garant, MD14Hak Choy, MD15Robert Timmerman, MD16James Brugarolas, MD, PhD17Raquibul Hannan, MD, PhD18Kidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, TexasDepartment of Radiation Oncology, University of California San Francisco, San Francisco, CaliforniaKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, TexasDepartment of Radiation Oncology, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Internal Medicine, Hematology-Oncology Division, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Internal Medicine, Hematology-Oncology Division, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Internal Medicine, Hematology-Oncology Division, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Internal Medicine, Hematology-Oncology Division, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Internal Medicine, Hematology-Oncology Division, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TexasDepartment of Radiation Oncology, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Radiation Oncology, Simmons Comprehensive Cancer Center, Dallas, TexasDepartment of Radiation Oncology, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Radiation Oncology, Simmons Comprehensive Cancer Center, Dallas, TexasKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Internal Medicine, Hematology-Oncology Division, Simmons Comprehensive Cancer Center, Dallas, Texas; Corresponding authors: James Brugarolas, MD, PhD and Raquibul Hannan, MD, PhDKidney Cancer Program, Simmons Comprehensive Cancer Center, Dallas, Texas; Department of Radiation Oncology, Simmons Comprehensive Cancer Center, Dallas, Texas; Corresponding authors: James Brugarolas, MD, PhD and Raquibul Hannan, MD, PhDPurpose: Oligoprogression, defined as limited sites of progression on systemic therapy, in patients with metastatic renal cell carcinoma (mRCC) is not uncommon, possibly because of inter- and intratumoral heterogeneity. We evaluated the effect of stereotactic ablative radiation therapy (SAbR) for longitudinal control of oligoprogressive mRCC. Methods and Materials: Patients with extracranial mRCC were included in this retrospective analysis if they progressed in ≤3 sites on systemic therapy while demonstrating response/stability at other sites and received SAbR to all progressing sites without switching systemic therapy. Our primary endpoint was modified progression-free survival (mPFS), which we calculated from the start of SAbR to the start of a subsequent systemic therapy, death, or loss to follow-up. Results: We identified 36 patients with a median follow-up of 20.4 months (interquartile range, 10.9-29.4). Forty-three sites were treated with SAbR with a median dose of 36 Gy (range, 18-50) in 3 fractions (range, 1-5). Median time to SAbR from the start of systemic therapy was 11.4 months (interquartile range, 6.1-17.1). Median mPFS was 9.2 months (95% confidence interval [CI], 5.9-13.2). Patients receiving SAbR while on immunotherapy exhibited a longer median mPFS (>28.4 months, log-rank P = .0001) than patients not on immunotherapy (9.2 months). Median overall survival from SAbR administration was 43.4 months (95% CI, 21.5-not Reached). The 1-year local control rate was 93% (95% CI, 78.7-97.5). Most SAbR-related toxicities were grade 1 to 2 (33% of patients), with one grade 5 hemoptysis event possibly related to SAbR or disease progression. Conclusions: SAbR has the potential to extend the the duration of current systemic therapy for selected patients with mRCC, preserving subsequent therapies for later administration possibly enabling longer treatment duration.http://www.sciencedirect.com/science/article/pii/S2452109421000506 |