Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke
Ischemic stroke (IS) is multifactorial causation combining with traditional cardiovascular disease (CVD) and genetic risk factors. Combined effects of MMP-7, MMP-8 and MMP-26 on the risk of IS remain incompletely understood. We aimed to assess individual and joint effects for IS risk by weighted gen...
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doaj-d3daf94829924f71812c518c4b8537e32020-11-25T01:53:24ZengMDPI AGJournal of Clinical Medicine2077-03832019-11-01811201110.3390/jcm8112011jcm8112011Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic StrokeFang-I Hsieh0Hung-Yi Chiou1Chaur-Jong Hu2Jiann-Shing Jeng3Huey-Juan Lin4Jiunn-Tay Lee5Li-Ming Lien6School of Public Health, College of Public Health, Taipei Medical University, Taipei 110, TaiwanSchool of Public Health, College of Public Health, Taipei Medical University, Taipei 110, TaiwanDepartment of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235, TaiwanStroke Center and Department of Neurology, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Neurology, Chi-Mei Medical Center, Tainan 710, TaiwanDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanSchool of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanIschemic stroke (IS) is multifactorial causation combining with traditional cardiovascular disease (CVD) and genetic risk factors. Combined effects of MMP-7, MMP-8 and MMP-26 on the risk of IS remain incompletely understood. We aimed to assess individual and joint effects for IS risk by weighted genetic risk score (wGRS) from these three genes and traditional CVD risk factors. A case-control study including 500 cases with IS and 500 stroke-free healthy controls frequency-matched with cases by age and sex was conducted. The wGRS was a weighted average of the number of risk genotype across selected SNPs from MMP-7, MMP-8 and MMP-26. Multivariate logistic regression models were used to analyze the relationship between wGRS and risk of IS. A wGRS in the second tertile was associated with a 1.5-fold increased risk of IS compared with the lowest tertile after adjusting for traditional CVD risk factors. Compared to subjects with low genetic and low modifiable CVD risk, those with high genetic and high modifiable CVD risk had the highest risk of IS (adjusted-OR = 5.75). In conclusion, higher wGRS was significantly associated with an increased risk for IS. A significant interaction between genetic and traditional CVD risk factors was also found on the risk of IS.https://www.mdpi.com/2077-0383/8/11/2011weighted genetic risk scoremmp-7mmp-8mmp-26ischemic stroke |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fang-I Hsieh Hung-Yi Chiou Chaur-Jong Hu Jiann-Shing Jeng Huey-Juan Lin Jiunn-Tay Lee Li-Ming Lien |
spellingShingle |
Fang-I Hsieh Hung-Yi Chiou Chaur-Jong Hu Jiann-Shing Jeng Huey-Juan Lin Jiunn-Tay Lee Li-Ming Lien Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke Journal of Clinical Medicine weighted genetic risk score mmp-7 mmp-8 mmp-26 ischemic stroke |
author_facet |
Fang-I Hsieh Hung-Yi Chiou Chaur-Jong Hu Jiann-Shing Jeng Huey-Juan Lin Jiunn-Tay Lee Li-Ming Lien |
author_sort |
Fang-I Hsieh |
title |
Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke |
title_short |
Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke |
title_full |
Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke |
title_fullStr |
Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke |
title_full_unstemmed |
Combined Effects of MMP-7, MMP-8 and MMP-26 on the Risk of Ischemic Stroke |
title_sort |
combined effects of mmp-7, mmp-8 and mmp-26 on the risk of ischemic stroke |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-11-01 |
description |
Ischemic stroke (IS) is multifactorial causation combining with traditional cardiovascular disease (CVD) and genetic risk factors. Combined effects of MMP-7, MMP-8 and MMP-26 on the risk of IS remain incompletely understood. We aimed to assess individual and joint effects for IS risk by weighted genetic risk score (wGRS) from these three genes and traditional CVD risk factors. A case-control study including 500 cases with IS and 500 stroke-free healthy controls frequency-matched with cases by age and sex was conducted. The wGRS was a weighted average of the number of risk genotype across selected SNPs from MMP-7, MMP-8 and MMP-26. Multivariate logistic regression models were used to analyze the relationship between wGRS and risk of IS. A wGRS in the second tertile was associated with a 1.5-fold increased risk of IS compared with the lowest tertile after adjusting for traditional CVD risk factors. Compared to subjects with low genetic and low modifiable CVD risk, those with high genetic and high modifiable CVD risk had the highest risk of IS (adjusted-OR = 5.75). In conclusion, higher wGRS was significantly associated with an increased risk for IS. A significant interaction between genetic and traditional CVD risk factors was also found on the risk of IS. |
topic |
weighted genetic risk score mmp-7 mmp-8 mmp-26 ischemic stroke |
url |
https://www.mdpi.com/2077-0383/8/11/2011 |
work_keys_str_mv |
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