Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

A lentiviral vector expressing a mutant huntingtin protein (htt171-82Q) was used to generate a chronic model of Huntington's disease (HD) in rat primary striatal cultures. In this model, the majority of neurons expressed the transgene so that Western blot analysis and flow cytometry measurement...

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Bibliographic Details
Main Authors: Diana Zala, Alexandra Benchoua, Emmanuel Brouillet, Valérie Perrin, Marie-Claude Gaillard, Anne D. Zurn, Patrick Aebischer, Nicole Déglon
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neurobiology of Disease
Subjects:
Striatal degeneration
Lentiviral vector
Mutant huntingtin
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610500149X

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