Mesenchymal Stem Cell Applications in Spine Disorders: A Comprehensive Review
Mesenchymal stem cells (MSCs) are increasingly being employed in a number of orthopedic settings, in particular in the treatment of hip and knee osteoarthritis. Recently, the use MSCs has been investigated for different spine settings. However, the use of these cells is not yet widespread in the cli...
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doaj-d3e6317c115b45649a81743cbf355d402021-09-09T13:38:49ZengMDPI AGApplied Sciences2076-34172021-08-01117966796610.3390/app11177966Mesenchymal Stem Cell Applications in Spine Disorders: A Comprehensive ReviewAlice Baroncini0Jörg Eschweiler1Philipp Kobbe2Valentin Quack3Samir Smajic4Per Trobisch5Frank Hildebrand6Filippo Migliorini7Department of Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University, 52074 Aachen, GermanyDepartment of Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University, 52074 Aachen, GermanyDepartment of Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University, 52074 Aachen, GermanyDepartment of Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University, 52074 Aachen, GermanyDepartment of Orthopaedic and Trauma Surgery, St-Josef-Krankenhaus, 52441 Linnich, GermanyDepartment of Spine Surgery, Eifelklinik St. Brigida, 52152 Simmerath, GermanyDepartment of Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University, 52074 Aachen, GermanyDepartment of Orthopaedics, Trauma and Reconstructive Surgery, RWTH Aachen University, 52074 Aachen, GermanyMesenchymal stem cells (MSCs) are increasingly being employed in a number of orthopedic settings, in particular in the treatment of hip and knee osteoarthritis. Recently, the use MSCs has been investigated for different spine settings. However, the use of these cells is not yet widespread in the clinical practice. The aim of this review was to investigate the current literature regarding the use of MSCs in different spine conditions and discuss possible future applications. In particular, degenerative disc disease is the most studied field for MSC application, and is the only one that has already reached the clinical practice, albeit not routinely. Spinal cord injuries are another extensively investigated use of MSCs: despite encouraging preliminary results, a consensus on the efficacy of stem cell therapy for spinal cord injuries has not yet been reached, and their use is still only experimental.https://www.mdpi.com/2076-3417/11/17/7966spinedegenerative disc diseaseSpinal Cord Injurymesenchymal stem cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alice Baroncini Jörg Eschweiler Philipp Kobbe Valentin Quack Samir Smajic Per Trobisch Frank Hildebrand Filippo Migliorini |
spellingShingle |
Alice Baroncini Jörg Eschweiler Philipp Kobbe Valentin Quack Samir Smajic Per Trobisch Frank Hildebrand Filippo Migliorini Mesenchymal Stem Cell Applications in Spine Disorders: A Comprehensive Review Applied Sciences spine degenerative disc disease Spinal Cord Injury mesenchymal stem cells |
author_facet |
Alice Baroncini Jörg Eschweiler Philipp Kobbe Valentin Quack Samir Smajic Per Trobisch Frank Hildebrand Filippo Migliorini |
author_sort |
Alice Baroncini |
title |
Mesenchymal Stem Cell Applications in Spine Disorders: A Comprehensive Review |
title_short |
Mesenchymal Stem Cell Applications in Spine Disorders: A Comprehensive Review |
title_full |
Mesenchymal Stem Cell Applications in Spine Disorders: A Comprehensive Review |
title_fullStr |
Mesenchymal Stem Cell Applications in Spine Disorders: A Comprehensive Review |
title_full_unstemmed |
Mesenchymal Stem Cell Applications in Spine Disorders: A Comprehensive Review |
title_sort |
mesenchymal stem cell applications in spine disorders: a comprehensive review |
publisher |
MDPI AG |
series |
Applied Sciences |
issn |
2076-3417 |
publishDate |
2021-08-01 |
description |
Mesenchymal stem cells (MSCs) are increasingly being employed in a number of orthopedic settings, in particular in the treatment of hip and knee osteoarthritis. Recently, the use MSCs has been investigated for different spine settings. However, the use of these cells is not yet widespread in the clinical practice. The aim of this review was to investigate the current literature regarding the use of MSCs in different spine conditions and discuss possible future applications. In particular, degenerative disc disease is the most studied field for MSC application, and is the only one that has already reached the clinical practice, albeit not routinely. Spinal cord injuries are another extensively investigated use of MSCs: despite encouraging preliminary results, a consensus on the efficacy of stem cell therapy for spinal cord injuries has not yet been reached, and their use is still only experimental. |
topic |
spine degenerative disc disease Spinal Cord Injury mesenchymal stem cells |
url |
https://www.mdpi.com/2076-3417/11/17/7966 |
work_keys_str_mv |
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1717760892208152576 |