Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies

Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies

The extracellular matrix (ECM) molecule Tenascin-C (TNC) is well-known to promote tumor progression by multiple mechanisms. However, reliable TNC detection in tissues of tumor banks remains limited. Therefore, we generated dromedary single-domain nanobodies Nb3 and Nb4 highly specific for human TNC...

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Main Authors: Sayda Dhaouadi, Rahma Ben Abderrazek, Thomas Loustau, Chérine Abou-Faycal, Ayoub Ksouri, William Erne, Devadarssen Murdamoothoo, Matthias Mörgelin, Andreas Kungl, Alain Jung, Sonia Ledrappier, Zakaria Benlasfar, Sandrine Bichet, Ruth Chiquet-Ehrismann, Ismaïl Hendaoui, Gertraud Orend, Balkiss Bouhaouala-Zahar
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
nanobody
extracellular matrix
tenascin-c
tumor biomarker
interaction modeling
diagnostic tool
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.635166/full

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