7,8-dimethoxycoumarin Attenuates the Expression of IL-6, IL-8, and CCL2/MCP-1 in TNF-α-Treated HaCaT Cells by Potentially Targeting the NF-κB and MAPK Pathways

7,8-dimethoxycoumarin Attenuates the Expression of IL-6, IL-8, and CCL2/MCP-1 in TNF-α-Treated HaCaT Cells by Potentially Targeting the NF-κB and MAPK Pathways

7,8-dimethoxycoumarin (DMC, C11H10O4), a natural coumarin compound, is present in <i>Citrus</i> plants including <i>Citrus decumana</i> and grapefruit. It is known to have protective effects on the kidneys against Cisplatin and ischemia-reperfusion injury. However, the underl...

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Bibliographic Details
Main Authors: Nari Lee, You Chul Chung, Choon Il Kang, Sung-Min Park, Chang-Gu Hyun
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cosmetics
Subjects:
7,8-dimethoxycoumarin
human keratinocyte HaCaT cell
skin inflammation
NF-κB
MAPK
Online Access:https://www.mdpi.com/2079-9284/6/3/41

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