Post-Transcriptional Regulation of Immunological Responses through Riboclustering
Immunological programming of immune cells varies in response to changing environmental signals. This process is facilitated by modifiers that regulate the translational fate of mRNAs encoding various immune mediators, including cytokines and chemokines, which in turn determine the rapid activation,...
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00161/full |
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doaj-d3fe33a620f74f098ee479f6dc4f2c5c2020-11-24T22:54:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-04-01710.3389/fimmu.2016.00161188239Post-Transcriptional Regulation of Immunological Responses through RiboclusteringNooruddin eKhan0Koelina eGanguly1Jeevan eGiddaluru2Avery eAugust3University of HyderabadUniversity of HyderabadUniversity of HyderabadCornell UniversityImmunological programming of immune cells varies in response to changing environmental signals. This process is facilitated by modifiers that regulate the translational fate of mRNAs encoding various immune mediators, including cytokines and chemokines, which in turn determine the rapid activation, tolerance, and plasticity of the immune system. RNA-binding proteins (RBPs) recruited by the specific sequence elements in mRNA transcripts are one such modifier. These RBPs form RBP-RNA complexes known as Riboclusters. These riboclusters serve as RNA sorting machinery, where depending upon the composition of the ribocluster, control translation, degradation or storage of mRNA. Recent findings suggest that this regulation of mRNA homeostasis is critical for controlling the immune response. Here, we present the current knowledge of the ribocluster-mediated post-transcriptional regulation of immune mediators, and highlight recent findings regarding their implications for the pathogenesis of acute or chronic inflammatory diseases.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00161/fullInflammationT cellmRNA stabilitystress granulespolysomesT CELL MATURATION |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nooruddin eKhan Koelina eGanguly Jeevan eGiddaluru Avery eAugust |
spellingShingle |
Nooruddin eKhan Koelina eGanguly Jeevan eGiddaluru Avery eAugust Post-Transcriptional Regulation of Immunological Responses through Riboclustering Frontiers in Immunology Inflammation T cell mRNA stability stress granules polysomes T CELL MATURATION |
author_facet |
Nooruddin eKhan Koelina eGanguly Jeevan eGiddaluru Avery eAugust |
author_sort |
Nooruddin eKhan |
title |
Post-Transcriptional Regulation of Immunological Responses through Riboclustering |
title_short |
Post-Transcriptional Regulation of Immunological Responses through Riboclustering |
title_full |
Post-Transcriptional Regulation of Immunological Responses through Riboclustering |
title_fullStr |
Post-Transcriptional Regulation of Immunological Responses through Riboclustering |
title_full_unstemmed |
Post-Transcriptional Regulation of Immunological Responses through Riboclustering |
title_sort |
post-transcriptional regulation of immunological responses through riboclustering |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2016-04-01 |
description |
Immunological programming of immune cells varies in response to changing environmental signals. This process is facilitated by modifiers that regulate the translational fate of mRNAs encoding various immune mediators, including cytokines and chemokines, which in turn determine the rapid activation, tolerance, and plasticity of the immune system. RNA-binding proteins (RBPs) recruited by the specific sequence elements in mRNA transcripts are one such modifier. These RBPs form RBP-RNA complexes known as Riboclusters. These riboclusters serve as RNA sorting machinery, where depending upon the composition of the ribocluster, control translation, degradation or storage of mRNA. Recent findings suggest that this regulation of mRNA homeostasis is critical for controlling the immune response. Here, we present the current knowledge of the ribocluster-mediated post-transcriptional regulation of immune mediators, and highlight recent findings regarding their implications for the pathogenesis of acute or chronic inflammatory diseases. |
topic |
Inflammation T cell mRNA stability stress granules polysomes T CELL MATURATION |
url |
http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00161/full |
work_keys_str_mv |
AT nooruddinekhan posttranscriptionalregulationofimmunologicalresponsesthroughriboclustering AT koelinaeganguly posttranscriptionalregulationofimmunologicalresponsesthroughriboclustering AT jeevanegiddaluru posttranscriptionalregulationofimmunologicalresponsesthroughriboclustering AT averyeaugust posttranscriptionalregulationofimmunologicalresponsesthroughriboclustering |
_version_ |
1725660818765250560 |