Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage
Objectives: Hyperglycemia and hypokalemia are common problems in patients with aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to determine whether the plasma glucose to potassium ratio (GPR) predicts mortality due to aSAH.Methods: We prospectively recruited aSAH patients and he...
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doaj-d425afb38bd04c7981eae3ea3cfebb122021-05-04T05:11:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-05-011210.3389/fneur.2021.661689661689Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid HemorrhageHyun Min Jung0Jin Hui Paik1Sin Young Kim2Dae Young Hong3Department of Emergency Medicine, Inha University School of Medicine, Incheon, South KoreaDepartment of Emergency Medicine, Inha University School of Medicine, Incheon, South KoreaDepartment of Emergency Medicine, Konkuk University School of Medicine, Seoul, South KoreaDepartment of Emergency Medicine, Konkuk University School of Medicine, Seoul, South KoreaObjectives: Hyperglycemia and hypokalemia are common problems in patients with aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to determine whether the plasma glucose to potassium ratio (GPR) predicts mortality due to aSAH.Methods: We prospectively recruited aSAH patients and healthy controls between March 2007 and May 2017. Clinical outcomes included mortality and poor outcome (modified Rankin scale score of 3-6) after 3 months. Multivariable analysis was used to determine the association between plasma GPR and 3-month mortality in aSAH patients.Results: A total of 553 patients were recruited, and the mortality rate was 11%. The GPR was significantly elevated in aSAH patients compared with controls, in patients with a poor outcome than with a good outcome and in non-survivals than in survivals. Multivariable analysis showed that the plasma GPR was an independent factor associated with 3-month mortality. The area under the curve of the GPR was 0.747 in predicting 3-month mortality.Conclusion: The plasma GPR on admission has potential as a predictor of 3-month mortality in patients with aSAH.https://www.frontiersin.org/articles/10.3389/fneur.2021.661689/fullaneurysmal subarachnoid hemorrhagebiomarkersglucosepotassiumprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyun Min Jung Jin Hui Paik Sin Young Kim Dae Young Hong |
spellingShingle |
Hyun Min Jung Jin Hui Paik Sin Young Kim Dae Young Hong Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage Frontiers in Neurology aneurysmal subarachnoid hemorrhage biomarkers glucose potassium prognosis |
author_facet |
Hyun Min Jung Jin Hui Paik Sin Young Kim Dae Young Hong |
author_sort |
Hyun Min Jung |
title |
Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage |
title_short |
Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage |
title_full |
Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage |
title_fullStr |
Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage |
title_full_unstemmed |
Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage |
title_sort |
association of plasma glucose to potassium ratio and mortality after aneurysmal subarachnoid hemorrhage |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2021-05-01 |
description |
Objectives: Hyperglycemia and hypokalemia are common problems in patients with aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to determine whether the plasma glucose to potassium ratio (GPR) predicts mortality due to aSAH.Methods: We prospectively recruited aSAH patients and healthy controls between March 2007 and May 2017. Clinical outcomes included mortality and poor outcome (modified Rankin scale score of 3-6) after 3 months. Multivariable analysis was used to determine the association between plasma GPR and 3-month mortality in aSAH patients.Results: A total of 553 patients were recruited, and the mortality rate was 11%. The GPR was significantly elevated in aSAH patients compared with controls, in patients with a poor outcome than with a good outcome and in non-survivals than in survivals. Multivariable analysis showed that the plasma GPR was an independent factor associated with 3-month mortality. The area under the curve of the GPR was 0.747 in predicting 3-month mortality.Conclusion: The plasma GPR on admission has potential as a predictor of 3-month mortality in patients with aSAH. |
topic |
aneurysmal subarachnoid hemorrhage biomarkers glucose potassium prognosis |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2021.661689/full |
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