CSF and Serum Biomarkers of Cerebral Damage in Autoimmune Epilepsy
Introduction: Our goal was to investigate whether biomarkers of cerebral damage are found in autoimmune-mediated epilepsy (AIE) and whether these can differentiate AIE from other seizure disorders.Methods: We retrospectively searched our cerebrospinal fluid (CSF) database for patients with definite...
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doaj-d44c71a0fa86493b9d1ef9dec44cf0c72021-04-16T04:54:29ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-04-011210.3389/fneur.2021.647428647428CSF and Serum Biomarkers of Cerebral Damage in Autoimmune EpilepsyRobert Daniel Nass0Katja Akgün1Karmele Olaciregui Dague2Christian Erich Elger3Heinz Reichmann4Tjalf Ziemssen5Rainer Surges6Department of Epileptology, University Hospital Bonn, Bonn, GermanyDepartment of Neurology, Dresden University Hospital, Dresden, GermanyDepartment of Epileptology, University Hospital Bonn, Bonn, GermanyDepartment of Epileptology, University Hospital Bonn, Bonn, GermanyDepartment of Neurology, Dresden University Hospital, Dresden, GermanyDepartment of Neurology, Dresden University Hospital, Dresden, GermanyDepartment of Epileptology, University Hospital Bonn, Bonn, GermanyIntroduction: Our goal was to investigate whether biomarkers of cerebral damage are found in autoimmune-mediated epilepsy (AIE) and whether these can differentiate AIE from other seizure disorders.Methods: We retrospectively searched our cerebrospinal fluid (CSF) database for patients with definite AIE, hippocampal sclerosis due to other causes (HS), genetic generalized epilepsy (GGE), and psychogenic, non-epileptic seizures (PNES). We measured serum and CSF tau, neurofilament 1 (NFL), glial fibrillary acid protein (GFAP), and ubiquitin-carboxy-terminal hydrolase L1 with a single-molecule array.Results: We identified suitable samples from patients with AIE (n = 13) with different antibodies and compared them to HS (n = 13), GGE (n = 7), and PNES (n = 8). The NFL levels were significantly elevated in the serum (p = 0.0009) and CSF (p < 0.0019) of AIE patients. The AIE group was significantly older, while the disease duration was significantly shorter than in the control groups. NFL correlated significantly with age in all groups, and the NFL levels of AIE patients were hardly higher than those of healthy elderly people published elsewhere.Conclusions: Our data indicate that the elevated NFL levels in AIE patients are most likely due to the higher age in this group and not due to the underlying inflammation. Unless larger prospective studies with intra-individual, longitudinal analyses and treatment responses would contradict our findings, NFL in serum might yet become a biomarker for disease activity and differential diagnosis.https://www.frontiersin.org/articles/10.3389/fneur.2021.647428/fullCSFserumepilepsytauneurofilamentNFL |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Robert Daniel Nass Katja Akgün Karmele Olaciregui Dague Christian Erich Elger Heinz Reichmann Tjalf Ziemssen Rainer Surges |
spellingShingle |
Robert Daniel Nass Katja Akgün Karmele Olaciregui Dague Christian Erich Elger Heinz Reichmann Tjalf Ziemssen Rainer Surges CSF and Serum Biomarkers of Cerebral Damage in Autoimmune Epilepsy Frontiers in Neurology CSF serum epilepsy tau neurofilament NFL |
author_facet |
Robert Daniel Nass Katja Akgün Karmele Olaciregui Dague Christian Erich Elger Heinz Reichmann Tjalf Ziemssen Rainer Surges |
author_sort |
Robert Daniel Nass |
title |
CSF and Serum Biomarkers of Cerebral Damage in Autoimmune Epilepsy |
title_short |
CSF and Serum Biomarkers of Cerebral Damage in Autoimmune Epilepsy |
title_full |
CSF and Serum Biomarkers of Cerebral Damage in Autoimmune Epilepsy |
title_fullStr |
CSF and Serum Biomarkers of Cerebral Damage in Autoimmune Epilepsy |
title_full_unstemmed |
CSF and Serum Biomarkers of Cerebral Damage in Autoimmune Epilepsy |
title_sort |
csf and serum biomarkers of cerebral damage in autoimmune epilepsy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2021-04-01 |
description |
Introduction: Our goal was to investigate whether biomarkers of cerebral damage are found in autoimmune-mediated epilepsy (AIE) and whether these can differentiate AIE from other seizure disorders.Methods: We retrospectively searched our cerebrospinal fluid (CSF) database for patients with definite AIE, hippocampal sclerosis due to other causes (HS), genetic generalized epilepsy (GGE), and psychogenic, non-epileptic seizures (PNES). We measured serum and CSF tau, neurofilament 1 (NFL), glial fibrillary acid protein (GFAP), and ubiquitin-carboxy-terminal hydrolase L1 with a single-molecule array.Results: We identified suitable samples from patients with AIE (n = 13) with different antibodies and compared them to HS (n = 13), GGE (n = 7), and PNES (n = 8). The NFL levels were significantly elevated in the serum (p = 0.0009) and CSF (p < 0.0019) of AIE patients. The AIE group was significantly older, while the disease duration was significantly shorter than in the control groups. NFL correlated significantly with age in all groups, and the NFL levels of AIE patients were hardly higher than those of healthy elderly people published elsewhere.Conclusions: Our data indicate that the elevated NFL levels in AIE patients are most likely due to the higher age in this group and not due to the underlying inflammation. Unless larger prospective studies with intra-individual, longitudinal analyses and treatment responses would contradict our findings, NFL in serum might yet become a biomarker for disease activity and differential diagnosis. |
topic |
CSF serum epilepsy tau neurofilament NFL |
url |
https://www.frontiersin.org/articles/10.3389/fneur.2021.647428/full |
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