Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer

Oxidative stress refers to an imbalance between reactive oxygen species (ROS) generation and body’s capability to detoxify the reactive mediators or to fix the relating damage. MicroRNAs are considered to be important mediators that play essential roles in the regulation of diverse aspects of carcin...

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Main Authors: Can Lu, Danting Zhou, Qiang Wang, Wenliang Liu, Fenglei Yu, Fang Wu, Chen Chen
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/2415324
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spelling doaj-d452a114786d4f94a587d215f2855a962020-11-25T02:01:35ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942020-01-01202010.1155/2020/24153242415324Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of CancerCan Lu0Danting Zhou1Qiang Wang2Wenliang Liu3Fenglei Yu4Fang Wu5Chen Chen6Centre of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, ChinaOxidative stress refers to an imbalance between reactive oxygen species (ROS) generation and body’s capability to detoxify the reactive mediators or to fix the relating damage. MicroRNAs are considered to be important mediators that play essential roles in the regulation of diverse aspects of carcinogenesis. Growing studies have demonstrated that the ROS can regulate microRNA biogenesis and expression mainly through modulating biogenesis course, transcription factors, and epigenetic changes. On the other hand, microRNAs may in turn modulate the redox signaling pathways, altering their integrity, stability, and functionality, thus contributing to the pathogenesis of multiple diseases. Both ROS and microRNAs have been identified to be important regulators and potential therapeutic targets in cancers. However, the information about the interplay between oxidative stress and microRNA regulation is still limited. The present review is aimed at summarizing the current understanding of molecular crosstalk between microRNAs and the generation of ROS in the pathogenesis of cancer.http://dx.doi.org/10.1155/2020/2415324
collection DOAJ
language English
format Article
sources DOAJ
author Can Lu
Danting Zhou
Qiang Wang
Wenliang Liu
Fenglei Yu
Fang Wu
Chen Chen
spellingShingle Can Lu
Danting Zhou
Qiang Wang
Wenliang Liu
Fenglei Yu
Fang Wu
Chen Chen
Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer
Oxidative Medicine and Cellular Longevity
author_facet Can Lu
Danting Zhou
Qiang Wang
Wenliang Liu
Fenglei Yu
Fang Wu
Chen Chen
author_sort Can Lu
title Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer
title_short Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer
title_full Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer
title_fullStr Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer
title_full_unstemmed Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer
title_sort crosstalk of micrornas and oxidative stress in the pathogenesis of cancer
publisher Hindawi Limited
series Oxidative Medicine and Cellular Longevity
issn 1942-0900
1942-0994
publishDate 2020-01-01
description Oxidative stress refers to an imbalance between reactive oxygen species (ROS) generation and body’s capability to detoxify the reactive mediators or to fix the relating damage. MicroRNAs are considered to be important mediators that play essential roles in the regulation of diverse aspects of carcinogenesis. Growing studies have demonstrated that the ROS can regulate microRNA biogenesis and expression mainly through modulating biogenesis course, transcription factors, and epigenetic changes. On the other hand, microRNAs may in turn modulate the redox signaling pathways, altering their integrity, stability, and functionality, thus contributing to the pathogenesis of multiple diseases. Both ROS and microRNAs have been identified to be important regulators and potential therapeutic targets in cancers. However, the information about the interplay between oxidative stress and microRNA regulation is still limited. The present review is aimed at summarizing the current understanding of molecular crosstalk between microRNAs and the generation of ROS in the pathogenesis of cancer.
url http://dx.doi.org/10.1155/2020/2415324
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AT wenliangliu crosstalkofmicrornasandoxidativestressinthepathogenesisofcancer
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