Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome
Abstract. Introduction:. Patients suffering from fibromyalgia syndrome (FMS) are heterogenous. They often present with sensory abnormalities and comorbidities. Objectives:. We aimed to answer the following questions: (1) Is there a specific somatosensory profile in our patient cohort? (2) Can we det...
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doaj-d456054024d14f7596d9963a52fe2abd2021-04-26T06:10:08ZengWolters KluwerPAIN Reports2471-25312021-01-0161e90110.1097/PR9.0000000000000901202101000-00037Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndromeStefanie Rehm0Juliane Sachau1Jana Hellriegel2Julia Forstenpointner3Henrik Børsting Jacobsen4Pontus Harten5Janne Gierthmühlen6Ralf Baron7a Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Germanya Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Germanyb Division of Psychiatry, Imland Klinik Rendsburg, Rendsburg, Germanya Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Germanyd Department of Pain Management and Research, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norwayf Practice for Rheumatology, Kiel, Germanya Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Germanya Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, GermanyAbstract. Introduction:. Patients suffering from fibromyalgia syndrome (FMS) are heterogenous. They often present with sensory abnormalities and comorbidities. Objectives:. We aimed to answer the following questions: (1) Is there a specific somatosensory profile in our patient cohort? (2) Can we detect subgroups characterized by a specific combination of sensory and psychological features? and (3) Do psychological parameters influence sensory signs? Methods:. In 87 patients with FMS quantitative sensory testing was performed on the hand and evaluated in combination with questionnaire results regarding pain, psychological comorbidities, sleep, and functionality. Results:. Patients presented different somatosensory patterns, but no specific subgroups regarding sensory signs and psychological features were detected. Hypersensitivity for noxious mechanical and thermal stimuli and hyposensitivity for nonnoxious mechanical stimuli were the most prominent features. Thirty-one percent of patients showed signs of central sensitization as indicated by abnormally increased pinprick hyperalgesia or dynamic mechanical allodynia. Central sensitization was associated with higher pain intensities (P < 0.001). Only a small influence of psychiatric comorbidities on mechanical pain sensitivity (P = 0.044) and vibration detection (P = 0.028) was found, which was partly associated with high pain intensities. A small subgroup of patients (11.4%) demonstrated thermal hyposensitivity (loss of small-fiber function). Conclusion:. Patients with FMS showed various somatosensory abnormalities. These were not significantly influenced by psychological comorbidities. Signs for central sensitization were detected in about one-third of patients and associated with higher pain intensities. This supports the notion of central sensitization being a major pathophysiological mechanism in FMS, whereas small-fiber loss may be less important.http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000901 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefanie Rehm Juliane Sachau Jana Hellriegel Julia Forstenpointner Henrik Børsting Jacobsen Pontus Harten Janne Gierthmühlen Ralf Baron |
spellingShingle |
Stefanie Rehm Juliane Sachau Jana Hellriegel Julia Forstenpointner Henrik Børsting Jacobsen Pontus Harten Janne Gierthmühlen Ralf Baron Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome PAIN Reports |
author_facet |
Stefanie Rehm Juliane Sachau Jana Hellriegel Julia Forstenpointner Henrik Børsting Jacobsen Pontus Harten Janne Gierthmühlen Ralf Baron |
author_sort |
Stefanie Rehm |
title |
Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome |
title_short |
Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome |
title_full |
Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome |
title_fullStr |
Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome |
title_full_unstemmed |
Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome |
title_sort |
pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome |
publisher |
Wolters Kluwer |
series |
PAIN Reports |
issn |
2471-2531 |
publishDate |
2021-01-01 |
description |
Abstract. Introduction:. Patients suffering from fibromyalgia syndrome (FMS) are heterogenous. They often present with sensory abnormalities and comorbidities.
Objectives:. We aimed to answer the following questions: (1) Is there a specific somatosensory profile in our patient cohort? (2) Can we detect subgroups characterized by a specific combination of sensory and psychological features? and (3) Do psychological parameters influence sensory signs?
Methods:. In 87 patients with FMS quantitative sensory testing was performed on the hand and evaluated in combination with questionnaire results regarding pain, psychological comorbidities, sleep, and functionality.
Results:. Patients presented different somatosensory patterns, but no specific subgroups regarding sensory signs and psychological features were detected. Hypersensitivity for noxious mechanical and thermal stimuli and hyposensitivity for nonnoxious mechanical stimuli were the most prominent features. Thirty-one percent of patients showed signs of central sensitization as indicated by abnormally increased pinprick hyperalgesia or dynamic mechanical allodynia. Central sensitization was associated with higher pain intensities (P < 0.001). Only a small influence of psychiatric comorbidities on mechanical pain sensitivity (P = 0.044) and vibration detection (P = 0.028) was found, which was partly associated with high pain intensities. A small subgroup of patients (11.4%) demonstrated thermal hyposensitivity (loss of small-fiber function).
Conclusion:. Patients with FMS showed various somatosensory abnormalities. These were not significantly influenced by psychological comorbidities. Signs for central sensitization were detected in about one-third of patients and associated with higher pain intensities. This supports the notion of central sensitization being a major pathophysiological mechanism in FMS, whereas small-fiber loss may be less important. |
url |
http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000000901 |
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