Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence

Personalized Medicine (PM) has shifted the traditional top-down approach to medicine based on the identification of single etiological factors to explain diseases, which was not suitable for explaining complex conditions. The concept of PM assumes several interpretations in the literature, with part...

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Main Authors: Alfredo Cesario, Marika D’Oria, Francesco Bove, Giuseppe Privitera, Ivo Boškoski, Daniela Pedicino, Luca Boldrini, Carmen Erra, Claudia Loreti, Giovanna Liuzzo, Filippo Crea, Alessandro Armuzzi, Antonio Gasbarrini, Paolo Calabresi, Luca Padua, Guido Costamagna, Massimo Antonelli, Vincenzo Valentini, Charles Auffray, Giovanni Scambia
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Personalized Medicine
Subjects:
Online Access:https://www.mdpi.com/2075-4426/11/4/265
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author Alfredo Cesario
Marika D’Oria
Francesco Bove
Giuseppe Privitera
Ivo Boškoski
Daniela Pedicino
Luca Boldrini
Carmen Erra
Claudia Loreti
Giovanna Liuzzo
Filippo Crea
Alessandro Armuzzi
Antonio Gasbarrini
Paolo Calabresi
Luca Padua
Guido Costamagna
Massimo Antonelli
Vincenzo Valentini
Charles Auffray
Giovanni Scambia
spellingShingle Alfredo Cesario
Marika D’Oria
Francesco Bove
Giuseppe Privitera
Ivo Boškoski
Daniela Pedicino
Luca Boldrini
Carmen Erra
Claudia Loreti
Giovanna Liuzzo
Filippo Crea
Alessandro Armuzzi
Antonio Gasbarrini
Paolo Calabresi
Luca Padua
Guido Costamagna
Massimo Antonelli
Vincenzo Valentini
Charles Auffray
Giovanni Scambia
Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence
Journal of Personalized Medicine
personalized medicine
systems medicine
gastroenterology
digestive endoscopy
cardiology
neurology
author_facet Alfredo Cesario
Marika D’Oria
Francesco Bove
Giuseppe Privitera
Ivo Boškoski
Daniela Pedicino
Luca Boldrini
Carmen Erra
Claudia Loreti
Giovanna Liuzzo
Filippo Crea
Alessandro Armuzzi
Antonio Gasbarrini
Paolo Calabresi
Luca Padua
Guido Costamagna
Massimo Antonelli
Vincenzo Valentini
Charles Auffray
Giovanni Scambia
author_sort Alfredo Cesario
title Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence
title_short Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence
title_full Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence
title_fullStr Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence
title_full_unstemmed Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence
title_sort personalized clinical phenotyping through systems medicine and artificial intelligence
publisher MDPI AG
series Journal of Personalized Medicine
issn 2075-4426
publishDate 2021-04-01
description Personalized Medicine (PM) has shifted the traditional top-down approach to medicine based on the identification of single etiological factors to explain diseases, which was not suitable for explaining complex conditions. The concept of PM assumes several interpretations in the literature, with particular regards to Genetic and Genomic Medicine. Despite the fact that some disease-modifying genes affect disease expression and progression, many complex conditions cannot be understood through only this lens, especially when other lifestyle factors can play a crucial role (such as the environment, emotions, nutrition, etc.). Personalizing clinical phenotyping becomes a challenge when different pathophysiological mechanisms underlie the same manifestation. Brain disorders, cardiovascular and gastroenterological diseases can be paradigmatic examples. Experiences on the field of Fondazione Policlinico Gemelli in Rome (a research hospital recognized by the Italian Ministry of Health as national leader in “Personalized Medicine” and “Innovative Biomedical Technologies”) could help understanding which techniques and tools are the most performing to develop potential clinical phenotypes personalization. The connection between practical experiences and scientific literature highlights how this potential can be reached towards Systems Medicine using Artificial Intelligence tools.
topic personalized medicine
systems medicine
gastroenterology
digestive endoscopy
cardiology
neurology
url https://www.mdpi.com/2075-4426/11/4/265
work_keys_str_mv AT alfredocesario personalizedclinicalphenotypingthroughsystemsmedicineandartificialintelligence
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spelling doaj-d45a0838696e4f2ea061b0a358e606492021-04-02T23:02:00ZengMDPI AGJournal of Personalized Medicine2075-44262021-04-011126526510.3390/jpm11040265Personalized Clinical Phenotyping through Systems Medicine and Artificial IntelligenceAlfredo Cesario0Marika D’Oria1Francesco Bove2Giuseppe Privitera3Ivo Boškoski4Daniela Pedicino5Luca Boldrini6Carmen Erra7Claudia Loreti8Giovanna Liuzzo9Filippo Crea10Alessandro Armuzzi11Antonio Gasbarrini12Paolo Calabresi13Luca Padua14Guido Costamagna15Massimo Antonelli16Vincenzo Valentini17Charles Auffray18Giovanni Scambia19Open Innovation Unit, Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyOpen Innovation Unit, Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCEMAD—IBD Unit—Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalySurgical Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCardiology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyRadiation Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyHigh Intensity Neurorehabilitation Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyHigh Intensity Neurorehabilitation Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCardiology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCardiology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCEMAD—IBD Unit—Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCEMAD—IBD Unit—Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyHigh Intensity Neurorehabilitation Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalySurgical Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyAnesthesia, Resuscitation, Intensive Care and Clinical Toxicology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyRadiation Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyEuropean Institute for Systems Biology and Medicine (EISBM), 69390 Vourles, FranceScientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyPersonalized Medicine (PM) has shifted the traditional top-down approach to medicine based on the identification of single etiological factors to explain diseases, which was not suitable for explaining complex conditions. The concept of PM assumes several interpretations in the literature, with particular regards to Genetic and Genomic Medicine. Despite the fact that some disease-modifying genes affect disease expression and progression, many complex conditions cannot be understood through only this lens, especially when other lifestyle factors can play a crucial role (such as the environment, emotions, nutrition, etc.). Personalizing clinical phenotyping becomes a challenge when different pathophysiological mechanisms underlie the same manifestation. Brain disorders, cardiovascular and gastroenterological diseases can be paradigmatic examples. Experiences on the field of Fondazione Policlinico Gemelli in Rome (a research hospital recognized by the Italian Ministry of Health as national leader in “Personalized Medicine” and “Innovative Biomedical Technologies”) could help understanding which techniques and tools are the most performing to develop potential clinical phenotypes personalization. The connection between practical experiences and scientific literature highlights how this potential can be reached towards Systems Medicine using Artificial Intelligence tools.https://www.mdpi.com/2075-4426/11/4/265personalized medicinesystems medicinegastroenterologydigestive endoscopycardiologyneurology