Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence
Personalized Medicine (PM) has shifted the traditional top-down approach to medicine based on the identification of single etiological factors to explain diseases, which was not suitable for explaining complex conditions. The concept of PM assumes several interpretations in the literature, with part...
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Format: | Article |
Language: | English |
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MDPI AG
2021-04-01
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Series: | Journal of Personalized Medicine |
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Online Access: | https://www.mdpi.com/2075-4426/11/4/265 |
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record_format |
Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alfredo Cesario Marika D’Oria Francesco Bove Giuseppe Privitera Ivo Boškoski Daniela Pedicino Luca Boldrini Carmen Erra Claudia Loreti Giovanna Liuzzo Filippo Crea Alessandro Armuzzi Antonio Gasbarrini Paolo Calabresi Luca Padua Guido Costamagna Massimo Antonelli Vincenzo Valentini Charles Auffray Giovanni Scambia |
spellingShingle |
Alfredo Cesario Marika D’Oria Francesco Bove Giuseppe Privitera Ivo Boškoski Daniela Pedicino Luca Boldrini Carmen Erra Claudia Loreti Giovanna Liuzzo Filippo Crea Alessandro Armuzzi Antonio Gasbarrini Paolo Calabresi Luca Padua Guido Costamagna Massimo Antonelli Vincenzo Valentini Charles Auffray Giovanni Scambia Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence Journal of Personalized Medicine personalized medicine systems medicine gastroenterology digestive endoscopy cardiology neurology |
author_facet |
Alfredo Cesario Marika D’Oria Francesco Bove Giuseppe Privitera Ivo Boškoski Daniela Pedicino Luca Boldrini Carmen Erra Claudia Loreti Giovanna Liuzzo Filippo Crea Alessandro Armuzzi Antonio Gasbarrini Paolo Calabresi Luca Padua Guido Costamagna Massimo Antonelli Vincenzo Valentini Charles Auffray Giovanni Scambia |
author_sort |
Alfredo Cesario |
title |
Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence |
title_short |
Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence |
title_full |
Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence |
title_fullStr |
Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence |
title_full_unstemmed |
Personalized Clinical Phenotyping through Systems Medicine and Artificial Intelligence |
title_sort |
personalized clinical phenotyping through systems medicine and artificial intelligence |
publisher |
MDPI AG |
series |
Journal of Personalized Medicine |
issn |
2075-4426 |
publishDate |
2021-04-01 |
description |
Personalized Medicine (PM) has shifted the traditional top-down approach to medicine based on the identification of single etiological factors to explain diseases, which was not suitable for explaining complex conditions. The concept of PM assumes several interpretations in the literature, with particular regards to Genetic and Genomic Medicine. Despite the fact that some disease-modifying genes affect disease expression and progression, many complex conditions cannot be understood through only this lens, especially when other lifestyle factors can play a crucial role (such as the environment, emotions, nutrition, etc.). Personalizing clinical phenotyping becomes a challenge when different pathophysiological mechanisms underlie the same manifestation. Brain disorders, cardiovascular and gastroenterological diseases can be paradigmatic examples. Experiences on the field of Fondazione Policlinico Gemelli in Rome (a research hospital recognized by the Italian Ministry of Health as national leader in “Personalized Medicine” and “Innovative Biomedical Technologies”) could help understanding which techniques and tools are the most performing to develop potential clinical phenotypes personalization. The connection between practical experiences and scientific literature highlights how this potential can be reached towards Systems Medicine using Artificial Intelligence tools. |
topic |
personalized medicine systems medicine gastroenterology digestive endoscopy cardiology neurology |
url |
https://www.mdpi.com/2075-4426/11/4/265 |
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doaj-d45a0838696e4f2ea061b0a358e606492021-04-02T23:02:00ZengMDPI AGJournal of Personalized Medicine2075-44262021-04-011126526510.3390/jpm11040265Personalized Clinical Phenotyping through Systems Medicine and Artificial IntelligenceAlfredo Cesario0Marika D’Oria1Francesco Bove2Giuseppe Privitera3Ivo Boškoski4Daniela Pedicino5Luca Boldrini6Carmen Erra7Claudia Loreti8Giovanna Liuzzo9Filippo Crea10Alessandro Armuzzi11Antonio Gasbarrini12Paolo Calabresi13Luca Padua14Guido Costamagna15Massimo Antonelli16Vincenzo Valentini17Charles Auffray18Giovanni Scambia19Open Innovation Unit, Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyOpen Innovation Unit, Scientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCEMAD—IBD Unit—Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalySurgical Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCardiology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyRadiation Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyHigh Intensity Neurorehabilitation Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyHigh Intensity Neurorehabilitation Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCardiology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCardiology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCEMAD—IBD Unit—Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyCEMAD—IBD Unit—Internal Medicine and Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyNeurology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyHigh Intensity Neurorehabilitation Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalySurgical Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyAnesthesia, Resuscitation, Intensive Care and Clinical Toxicology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyRadiation Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyEuropean Institute for Systems Biology and Medicine (EISBM), 69390 Vourles, FranceScientific Directorate, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyPersonalized Medicine (PM) has shifted the traditional top-down approach to medicine based on the identification of single etiological factors to explain diseases, which was not suitable for explaining complex conditions. The concept of PM assumes several interpretations in the literature, with particular regards to Genetic and Genomic Medicine. Despite the fact that some disease-modifying genes affect disease expression and progression, many complex conditions cannot be understood through only this lens, especially when other lifestyle factors can play a crucial role (such as the environment, emotions, nutrition, etc.). Personalizing clinical phenotyping becomes a challenge when different pathophysiological mechanisms underlie the same manifestation. Brain disorders, cardiovascular and gastroenterological diseases can be paradigmatic examples. Experiences on the field of Fondazione Policlinico Gemelli in Rome (a research hospital recognized by the Italian Ministry of Health as national leader in “Personalized Medicine” and “Innovative Biomedical Technologies”) could help understanding which techniques and tools are the most performing to develop potential clinical phenotypes personalization. The connection between practical experiences and scientific literature highlights how this potential can be reached towards Systems Medicine using Artificial Intelligence tools.https://www.mdpi.com/2075-4426/11/4/265personalized medicinesystems medicinegastroenterologydigestive endoscopycardiologyneurology |