Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes
Gut microbiota and their biomarkers may be associated with obesity. This study evaluated associations of body mass index (BMI) with circulating microbiota biomarkers in African American men (AAM) (<i>n</i> = 75). The main outcomes included fecal microbial community structure (16S rRNA),...
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doaj-d45c741ee63b42879fb751ec675a09ce2020-11-25T01:36:27ZengMDPI AGMicroorganisms2076-26072019-09-017932010.3390/microorganisms7090320microorganisms7090320Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without DiabetesElena Barengolts0Stefan J. Green1George E. Chlipala2Brian T. Layden3Yuval Eisenberg4Medha Priyadarshini5Lara R. Dugas6Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USASequencing Core, Research Resources Center, University of Illinois, Chicago, IL 60612, USAResearch Informatics Core, Research Resources Center, University of Illinois, Chicago, IL 60612, USADivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USADepartment of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL 60153, USAGut microbiota and their biomarkers may be associated with obesity. This study evaluated associations of body mass index (BMI) with circulating microbiota biomarkers in African American men (AAM) (<i>n</i> = 75). The main outcomes included fecal microbial community structure (16S rRNA), gut permeability biomarkers (ELISA), and short-chain fatty acids (SCFAs, metabolome analysis). These outcomes were compared between obese and non-obese men, after adjusting for age. The results showed that lipopolysaccharide-binding protein (LBP), the ratio of LBP to CD14 (LBP/CD14), and SCFAs (propionic, butyric, isovaleric) were higher in obese (<i>n</i> = 41, age 58 years, BMI 36 kg/m<sup>2</sup>) versus non-obese (<i>n</i> = 34, age 55 years, BMI 26 kg/m<sup>2</sup>) men. BMI correlated positively with LBP, LBP/CD14 (<i>p</i> < 0.05 for both) and SCFAs (propionic, butyric, isovaleric, <i>p</i> < 0.01 for all). In the regression analysis, LBP, LBP/CD14, propionic and butyric acids were independent determinants of BMI. The study showed for the first time that selected microbiota biomarkers (LBP, LBP/CD14, propionic and butyric acids) together with several other relevant risks explained 39%−47% of BMI variability, emphasizing that factors other than microbiota-related biomarkers could be important. Further research is needed to provide clinical and mechanistic insight into microbiota biomarkers and their utility for diagnostic and therapeutic purposes.https://www.mdpi.com/2076-2607/7/9/320gut microbiotaBMIbody mass indexCD14cluster of differentiation 14 proteinEndoCabendotoxin core antibodyLBPlipopolysaccharide-binding proteinSCFAshort-chain fatty acidszonulinbutyricpropionicobesitytype 2 diabetes mellitusAfrican American mencortisol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elena Barengolts Stefan J. Green George E. Chlipala Brian T. Layden Yuval Eisenberg Medha Priyadarshini Lara R. Dugas |
spellingShingle |
Elena Barengolts Stefan J. Green George E. Chlipala Brian T. Layden Yuval Eisenberg Medha Priyadarshini Lara R. Dugas Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes Microorganisms gut microbiota BMI body mass index CD14 cluster of differentiation 14 protein EndoCab endotoxin core antibody LBP lipopolysaccharide-binding protein SCFA short-chain fatty acids zonulin butyric propionic obesity type 2 diabetes mellitus African American men cortisol |
author_facet |
Elena Barengolts Stefan J. Green George E. Chlipala Brian T. Layden Yuval Eisenberg Medha Priyadarshini Lara R. Dugas |
author_sort |
Elena Barengolts |
title |
Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes |
title_short |
Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes |
title_full |
Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes |
title_fullStr |
Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes |
title_full_unstemmed |
Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes |
title_sort |
predictors of obesity among gut microbiota biomarkers in african american men with and without diabetes |
publisher |
MDPI AG |
series |
Microorganisms |
issn |
2076-2607 |
publishDate |
2019-09-01 |
description |
Gut microbiota and their biomarkers may be associated with obesity. This study evaluated associations of body mass index (BMI) with circulating microbiota biomarkers in African American men (AAM) (<i>n</i> = 75). The main outcomes included fecal microbial community structure (16S rRNA), gut permeability biomarkers (ELISA), and short-chain fatty acids (SCFAs, metabolome analysis). These outcomes were compared between obese and non-obese men, after adjusting for age. The results showed that lipopolysaccharide-binding protein (LBP), the ratio of LBP to CD14 (LBP/CD14), and SCFAs (propionic, butyric, isovaleric) were higher in obese (<i>n</i> = 41, age 58 years, BMI 36 kg/m<sup>2</sup>) versus non-obese (<i>n</i> = 34, age 55 years, BMI 26 kg/m<sup>2</sup>) men. BMI correlated positively with LBP, LBP/CD14 (<i>p</i> < 0.05 for both) and SCFAs (propionic, butyric, isovaleric, <i>p</i> < 0.01 for all). In the regression analysis, LBP, LBP/CD14, propionic and butyric acids were independent determinants of BMI. The study showed for the first time that selected microbiota biomarkers (LBP, LBP/CD14, propionic and butyric acids) together with several other relevant risks explained 39%−47% of BMI variability, emphasizing that factors other than microbiota-related biomarkers could be important. Further research is needed to provide clinical and mechanistic insight into microbiota biomarkers and their utility for diagnostic and therapeutic purposes. |
topic |
gut microbiota BMI body mass index CD14 cluster of differentiation 14 protein EndoCab endotoxin core antibody LBP lipopolysaccharide-binding protein SCFA short-chain fatty acids zonulin butyric propionic obesity type 2 diabetes mellitus African American men cortisol |
url |
https://www.mdpi.com/2076-2607/7/9/320 |
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