Human bocavirus-1 screening in infants with acute lower respiratory tract infection
Background Recent studies have reported associations between, human bocavirus (HBoV), and respiratory tract diseases in children. However, there is limited information on the epidemiology of HBoV in infants. This prospective study investigated the prevalence and clinical characteristics of HBoV infe...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2021-08-01
|
Series: | Journal of International Medical Research |
Online Access: | https://doi.org/10.1177/03000605211027739 |
id |
doaj-d45dbea495e14bf1b9c28653c16198b7 |
---|---|
record_format |
Article |
spelling |
doaj-d45dbea495e14bf1b9c28653c16198b72021-08-26T23:33:38ZengSAGE PublishingJournal of International Medical Research1473-23002021-08-014910.1177/03000605211027739Human bocavirus-1 screening in infants with acute lower respiratory tract infectionXingang ZhangJishan ZhengLihua ZhuHuiqing XuBackground Recent studies have reported associations between, human bocavirus (HBoV), and respiratory tract diseases in children. However, there is limited information on the epidemiology of HBoV in infants. This prospective study investigated the prevalence and clinical characteristics of HBoV infection in infants with acute lower respiratory tract infection (ALRTI) in eastern China. Methods Nasopharyngeal aspirates and throat swab samples were collected from infants with ALRTI and age-matched healthy infants between January 2016 and December 2019. HBoV was identified by polymerase chain reaction. Laboratory data and clinical characteristics were analyzed. Results Of 2510 infants, 145 tested positive for HBoV. The highest prevalence of HBoV was detected during the winter. Co-infection was frequently observed during this period of high viral transmission. There were no HBoV-positive infants in the control group. Clinical signs and symptoms included cough, wheezing, fever, nasal discharge, vomiting, diarrhea, hypoxemia, and tachypnea. Co-infections included: Streptococcus pneumoniae , Staphylococcus aureus , Mycoplasma pneumoniae , Chlamydophila pneumoniae , respiratory syncytial virus, and adenovirus. Conclusions HBoV was frequently detected in infants with ALRTI in China. The prevalence of HBoV was highest in winter. Co-infection was common, especially in infants requiring intensive care unit admission. Comprehensive clinical evaluation may facilitate optimal treatment.https://doi.org/10.1177/03000605211027739 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xingang Zhang Jishan Zheng Lihua Zhu Huiqing Xu |
spellingShingle |
Xingang Zhang Jishan Zheng Lihua Zhu Huiqing Xu Human bocavirus-1 screening in infants with acute lower respiratory tract infection Journal of International Medical Research |
author_facet |
Xingang Zhang Jishan Zheng Lihua Zhu Huiqing Xu |
author_sort |
Xingang Zhang |
title |
Human bocavirus-1 screening in infants with acute lower respiratory tract infection |
title_short |
Human bocavirus-1 screening in infants with acute lower respiratory tract infection |
title_full |
Human bocavirus-1 screening in infants with acute lower respiratory tract infection |
title_fullStr |
Human bocavirus-1 screening in infants with acute lower respiratory tract infection |
title_full_unstemmed |
Human bocavirus-1 screening in infants with acute lower respiratory tract infection |
title_sort |
human bocavirus-1 screening in infants with acute lower respiratory tract infection |
publisher |
SAGE Publishing |
series |
Journal of International Medical Research |
issn |
1473-2300 |
publishDate |
2021-08-01 |
description |
Background Recent studies have reported associations between, human bocavirus (HBoV), and respiratory tract diseases in children. However, there is limited information on the epidemiology of HBoV in infants. This prospective study investigated the prevalence and clinical characteristics of HBoV infection in infants with acute lower respiratory tract infection (ALRTI) in eastern China. Methods Nasopharyngeal aspirates and throat swab samples were collected from infants with ALRTI and age-matched healthy infants between January 2016 and December 2019. HBoV was identified by polymerase chain reaction. Laboratory data and clinical characteristics were analyzed. Results Of 2510 infants, 145 tested positive for HBoV. The highest prevalence of HBoV was detected during the winter. Co-infection was frequently observed during this period of high viral transmission. There were no HBoV-positive infants in the control group. Clinical signs and symptoms included cough, wheezing, fever, nasal discharge, vomiting, diarrhea, hypoxemia, and tachypnea. Co-infections included: Streptococcus pneumoniae , Staphylococcus aureus , Mycoplasma pneumoniae , Chlamydophila pneumoniae , respiratory syncytial virus, and adenovirus. Conclusions HBoV was frequently detected in infants with ALRTI in China. The prevalence of HBoV was highest in winter. Co-infection was common, especially in infants requiring intensive care unit admission. Comprehensive clinical evaluation may facilitate optimal treatment. |
url |
https://doi.org/10.1177/03000605211027739 |
work_keys_str_mv |
AT xingangzhang humanbocavirus1screeningininfantswithacutelowerrespiratorytractinfection AT jishanzheng humanbocavirus1screeningininfantswithacutelowerrespiratorytractinfection AT lihuazhu humanbocavirus1screeningininfantswithacutelowerrespiratorytractinfection AT huiqingxu humanbocavirus1screeningininfantswithacutelowerrespiratorytractinfection |
_version_ |
1721189190221168640 |