Hormone Replacement Versus Natural Cycle Protocols of Endometrial Preparation for Frozen Embryo Transfer
Research questionEndometrial preparation is one of the most important steps for ensuring frozen embryo transfer success. However, there is no clear evidence that identifies an optimal endometrial preparation protocol for frozen embryo transfer. In addition, in studies that assessed which were the op...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-09-01
|
Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.546532/full |
id |
doaj-d46143ed1dc746118785b28a60cb5628 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ye Pan Ye Pan Ye Pan Ye Pan Ye Pan Bo Li Bo Li Ze Wang Ze Wang Ze Wang Ze Wang Ze Wang Ying Wang Ying Wang Ying Wang Ying Wang Ying Wang Xiaoshu Gong Xiaoshu Gong Xiaoshu Gong Xiaoshu Gong Xiaoshu Gong Wenqing Zhou Wenqing Zhou Wenqing Zhou Wenqing Zhou Wenqing Zhou Yuhua Shi Yuhua Shi Yuhua Shi Yuhua Shi Yuhua Shi |
spellingShingle |
Ye Pan Ye Pan Ye Pan Ye Pan Ye Pan Bo Li Bo Li Ze Wang Ze Wang Ze Wang Ze Wang Ze Wang Ying Wang Ying Wang Ying Wang Ying Wang Ying Wang Xiaoshu Gong Xiaoshu Gong Xiaoshu Gong Xiaoshu Gong Xiaoshu Gong Wenqing Zhou Wenqing Zhou Wenqing Zhou Wenqing Zhou Wenqing Zhou Yuhua Shi Yuhua Shi Yuhua Shi Yuhua Shi Yuhua Shi Hormone Replacement Versus Natural Cycle Protocols of Endometrial Preparation for Frozen Embryo Transfer Frontiers in Endocrinology caesarean section frozen embryo transfer hormone replacement therapy cycle natural cycle implantation rate |
author_facet |
Ye Pan Ye Pan Ye Pan Ye Pan Ye Pan Bo Li Bo Li Ze Wang Ze Wang Ze Wang Ze Wang Ze Wang Ying Wang Ying Wang Ying Wang Ying Wang Ying Wang Xiaoshu Gong Xiaoshu Gong Xiaoshu Gong Xiaoshu Gong Xiaoshu Gong Wenqing Zhou Wenqing Zhou Wenqing Zhou Wenqing Zhou Wenqing Zhou Yuhua Shi Yuhua Shi Yuhua Shi Yuhua Shi Yuhua Shi |
author_sort |
Ye Pan |
title |
Hormone Replacement Versus Natural Cycle Protocols of Endometrial Preparation for Frozen Embryo Transfer |
title_short |
Hormone Replacement Versus Natural Cycle Protocols of Endometrial Preparation for Frozen Embryo Transfer |
title_full |
Hormone Replacement Versus Natural Cycle Protocols of Endometrial Preparation for Frozen Embryo Transfer |
title_fullStr |
Hormone Replacement Versus Natural Cycle Protocols of Endometrial Preparation for Frozen Embryo Transfer |
title_full_unstemmed |
Hormone Replacement Versus Natural Cycle Protocols of Endometrial Preparation for Frozen Embryo Transfer |
title_sort |
hormone replacement versus natural cycle protocols of endometrial preparation for frozen embryo transfer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2020-09-01 |
description |
Research questionEndometrial preparation is one of the most important steps for ensuring frozen embryo transfer success. However, there is no clear evidence that identifies an optimal endometrial preparation protocol for frozen embryo transfer. In addition, in studies that assessed which were the optimal endometrial preparation protocols, few analyzed the stage and the number of embryos. This study compared the pregnancy outcomes and perinatal obstetric complications of patients who were transferred two cleavage-stage (day 2 or day 3) frozen embryos with the natural cycle and those with the hormone replacement therapy cycle.DesignThis study was a secondary analysis of data from a multicentre randomized controlled trial designed to compare the pregnancy and perinatal outcomes after frozen versus fresh embryo transfer. In this study, a total of 908 patients who were transferred two cleavage-stage (day 2 or day 3) embryos in the original trial were analyzed. Pregnancy outcomes and perinatal obstetric complications after the natural cycle and the hormone replacement therapy cycle were compared.ResultWe found the endometrium in the natural group was significantly thicker than the hormone replacement therapy cycle group (p<0.01). The implantation rate (42.6% vs 37.3% p=0.049) showed a significant difference between the natural cycle group and the hormone replacement therapy cycle group. Compared to the natural cycle group, the hormone replacement therapy cycle group was associated with an increased risk of caesarean section (72.3% vs 84.5, p=0.009).ConclusionThe natural cycle protocol yielded thicker endometria, a higher implantation rate and a lower risk of caesarean section than the hormone replacement therapy protocol in the transfer of two cleavage-stage frozen embryos. The natural cycle protocol was the better endometrial preparation protocol for frozen embryo transfer. |
topic |
caesarean section frozen embryo transfer hormone replacement therapy cycle natural cycle implantation rate |
url |
https://www.frontiersin.org/article/10.3389/fendo.2020.546532/full |
work_keys_str_mv |
AT yepan hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yepan hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yepan hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yepan hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yepan hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT boli hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT boli hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT zewang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT zewang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT zewang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT zewang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT zewang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yingwang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yingwang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yingwang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yingwang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yingwang hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT xiaoshugong hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT xiaoshugong hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT xiaoshugong hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT xiaoshugong hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT xiaoshugong hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT wenqingzhou hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT wenqingzhou hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT wenqingzhou hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT wenqingzhou hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT wenqingzhou hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yuhuashi hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yuhuashi hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yuhuashi hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yuhuashi hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer AT yuhuashi hormonereplacementversusnaturalcycleprotocolsofendometrialpreparationforfrozenembryotransfer |
_version_ |
1724458173510713344 |
spelling |
doaj-d46143ed1dc746118785b28a60cb56282020-11-25T03:58:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-09-011110.3389/fendo.2020.546532546532Hormone Replacement Versus Natural Cycle Protocols of Endometrial Preparation for Frozen Embryo TransferYe Pan0Ye Pan1Ye Pan2Ye Pan3Ye Pan4Bo Li5Bo Li6Ze Wang7Ze Wang8Ze Wang9Ze Wang10Ze Wang11Ying Wang12Ying Wang13Ying Wang14Ying Wang15Ying Wang16Xiaoshu Gong17Xiaoshu Gong18Xiaoshu Gong19Xiaoshu Gong20Xiaoshu Gong21Wenqing Zhou22Wenqing Zhou23Wenqing Zhou24Wenqing Zhou25Wenqing Zhou26Yuhua Shi27Yuhua Shi28Yuhua Shi29Yuhua Shi30Yuhua Shi31Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaQingdao Women and Children’s Hospital, Qingdao, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaKey Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, ChinaShandong Key Laboratory of Reproductive Medicine, Jinan, ChinaShandong Provincial Clinical Research Center for Reproductive Health, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, ChinaResearch questionEndometrial preparation is one of the most important steps for ensuring frozen embryo transfer success. However, there is no clear evidence that identifies an optimal endometrial preparation protocol for frozen embryo transfer. In addition, in studies that assessed which were the optimal endometrial preparation protocols, few analyzed the stage and the number of embryos. This study compared the pregnancy outcomes and perinatal obstetric complications of patients who were transferred two cleavage-stage (day 2 or day 3) frozen embryos with the natural cycle and those with the hormone replacement therapy cycle.DesignThis study was a secondary analysis of data from a multicentre randomized controlled trial designed to compare the pregnancy and perinatal outcomes after frozen versus fresh embryo transfer. In this study, a total of 908 patients who were transferred two cleavage-stage (day 2 or day 3) embryos in the original trial were analyzed. Pregnancy outcomes and perinatal obstetric complications after the natural cycle and the hormone replacement therapy cycle were compared.ResultWe found the endometrium in the natural group was significantly thicker than the hormone replacement therapy cycle group (p<0.01). The implantation rate (42.6% vs 37.3% p=0.049) showed a significant difference between the natural cycle group and the hormone replacement therapy cycle group. Compared to the natural cycle group, the hormone replacement therapy cycle group was associated with an increased risk of caesarean section (72.3% vs 84.5, p=0.009).ConclusionThe natural cycle protocol yielded thicker endometria, a higher implantation rate and a lower risk of caesarean section than the hormone replacement therapy protocol in the transfer of two cleavage-stage frozen embryos. The natural cycle protocol was the better endometrial preparation protocol for frozen embryo transfer.https://www.frontiersin.org/article/10.3389/fendo.2020.546532/fullcaesarean sectionfrozen embryo transferhormone replacement therapy cyclenatural cycleimplantation rate |