Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients

Overnutrition has been linked to increased risk of cancer. Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation.

Bibliographic Details
Main Authors:	Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu, Shi-Min Zhao, Wei Xu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00489-5

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spelling	doaj-d46815d31f134af6aa2e2ea7608d395c2021-05-11T07:50:45ZengNature Publishing GroupNature Communications2041-17232017-09-018111610.1038/s41467-017-00489-5Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrientsYa-Kun Zhang0Yuan-Yuan Qu1Yan Lin2Xiao-Hui Wu3Hou-Zao Chen4Xu Wang5Kai-Qiang Zhou6Yun Wei7Fushen Guo8Cui-Fang Yao9Xia-Di He10Li-Xia Liu11Chen Yang12Zong-Yuan Guan13Shi-Dong Wang14Jianyuan Zhao15De-Pei Liu16Shi-Min Zhao17Wei Xu18Obstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesDepartment of Urology, Fudan University Shanghai Cancer CenterObstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesInstitute of Developmental Biology and Molecular Medicine, Fudan UniversityState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical CollegeObstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesObstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesObstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesObstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesObstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesInstitute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInstitute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesSophie Davis School of Biomedical Education, City University of New York Medical SchoolVanderbilt University School of MedicineObstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesState Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical CollegeObstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesObstetrics & Gynecology Hospital of Fudan University, State Key Lab of Genetic Engineering, Institutes of Biomedical Sciences and School of Life SciencesOvernutrition has been linked to increased risk of cancer. Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation.https://doi.org/10.1038/s41467-017-00489-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ya-Kun Zhang Yuan-Yuan Qu Yan Lin Xiao-Hui Wu Hou-Zao Chen Xu Wang Kai-Qiang Zhou Yun Wei Fushen Guo Cui-Fang Yao Xia-Di He Li-Xia Liu Chen Yang Zong-Yuan Guan Shi-Dong Wang Jianyuan Zhao De-Pei Liu Shi-Min Zhao Wei Xu
spellingShingle	Ya-Kun Zhang Yuan-Yuan Qu Yan Lin Xiao-Hui Wu Hou-Zao Chen Xu Wang Kai-Qiang Zhou Yun Wei Fushen Guo Cui-Fang Yao Xia-Di He Li-Xia Liu Chen Yang Zong-Yuan Guan Shi-Dong Wang Jianyuan Zhao De-Pei Liu Shi-Min Zhao Wei Xu Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients Nature Communications
author_facet	Ya-Kun Zhang Yuan-Yuan Qu Yan Lin Xiao-Hui Wu Hou-Zao Chen Xu Wang Kai-Qiang Zhou Yun Wei Fushen Guo Cui-Fang Yao Xia-Di He Li-Xia Liu Chen Yang Zong-Yuan Guan Shi-Dong Wang Jianyuan Zhao De-Pei Liu Shi-Min Zhao Wei Xu
author_sort	Ya-Kun Zhang
title	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_short	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_full	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_fullStr	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_full_unstemmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_sort	enoyl-coa hydratase-1 regulates mtor signaling and apoptosis by sensing nutrients
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-09-01
description	Overnutrition has been linked to increased risk of cancer. Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation.
url	https://doi.org/10.1038/s41467-017-00489-5
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Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients

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