Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape

Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of negative feedback through Sprouty gene deletion rem...

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Bibliographic Details
Main Authors: Behnam Nabet, Pilib Ó Broin, Jaime M. Reyes, Kevin Shieh, Charles Y. Lin, Christine M. Will, Relja Popovic, Teresa Ezponda, James E. Bradner, Aaron A. Golden, Jonathan D. Licht
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715008220

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http://www.sciencedirect.com/science/article/pii/S2211124715008220

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