The genomic landscape of pediatric myelodysplastic syndromes

Myelodysplastic syndromes (MDS) are uncommon in children and have poor prognosis. Here, the authors interrogate the genomic landscape of MDS, confirming adult and paediatric MDS are separate diseases with disparate mechanisms, and highlighting that SAMD9/SAMD9L mutations represent a new class of MDS...

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Main Authors:	Jason R. Schwartz, Jing Ma, Tamara Lamprecht, Michael Walsh, Shuoguo Wang, Victoria Bryant, Guangchun Song, Gang Wu, John Easton, Chimene Kesserwan, Kim E. Nichols, Charles G. Mullighan, Raul C. Ribeiro, Jeffery M. Klco
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01590-5

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spelling	doaj-d4725852501c4cd68e3d57d74d9225b12021-05-11T07:44:40ZengNature Publishing GroupNature Communications2041-17232017-11-018111010.1038/s41467-017-01590-5The genomic landscape of pediatric myelodysplastic syndromesJason R. Schwartz0Jing Ma1Tamara Lamprecht2Michael Walsh3Shuoguo Wang4Victoria Bryant5Guangchun Song6Gang Wu7John Easton8Chimene Kesserwan9Kim E. Nichols10Charles G. Mullighan11Raul C. Ribeiro12Jeffery M. Klco13Department of Oncology, St. Jude Children’s Research HospitalDepartment of Pathology, St. Jude Children’s Research HospitalDepartment of Pathology, St. Jude Children’s Research HospitalDepartment of Pathology, St. Jude Children’s Research HospitalDepartment of Computational Biology, St. Jude Children’s Research HospitalDepartment of Pathology, St. Jude Children’s Research HospitalDepartment of Pathology, St. Jude Children’s Research HospitalDepartment of Computational Biology, St. Jude Children’s Research HospitalDepartment of Computational Biology, St. Jude Children’s Research HospitalDepartment of Oncology, St. Jude Children’s Research HospitalDepartment of Oncology, St. Jude Children’s Research HospitalDepartment of Pathology, St. Jude Children’s Research HospitalDepartment of Oncology, St. Jude Children’s Research HospitalDepartment of Pathology, St. Jude Children’s Research HospitalMyelodysplastic syndromes (MDS) are uncommon in children and have poor prognosis. Here, the authors interrogate the genomic landscape of MDS, confirming adult and paediatric MDS are separate diseases with disparate mechanisms, and highlighting that SAMD9/SAMD9L mutations represent a new class of MDS predisposition.https://doi.org/10.1038/s41467-017-01590-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jason R. Schwartz Jing Ma Tamara Lamprecht Michael Walsh Shuoguo Wang Victoria Bryant Guangchun Song Gang Wu John Easton Chimene Kesserwan Kim E. Nichols Charles G. Mullighan Raul C. Ribeiro Jeffery M. Klco
spellingShingle	Jason R. Schwartz Jing Ma Tamara Lamprecht Michael Walsh Shuoguo Wang Victoria Bryant Guangchun Song Gang Wu John Easton Chimene Kesserwan Kim E. Nichols Charles G. Mullighan Raul C. Ribeiro Jeffery M. Klco The genomic landscape of pediatric myelodysplastic syndromes Nature Communications
author_facet	Jason R. Schwartz Jing Ma Tamara Lamprecht Michael Walsh Shuoguo Wang Victoria Bryant Guangchun Song Gang Wu John Easton Chimene Kesserwan Kim E. Nichols Charles G. Mullighan Raul C. Ribeiro Jeffery M. Klco
author_sort	Jason R. Schwartz
title	The genomic landscape of pediatric myelodysplastic syndromes
title_short	The genomic landscape of pediatric myelodysplastic syndromes
title_full	The genomic landscape of pediatric myelodysplastic syndromes
title_fullStr	The genomic landscape of pediatric myelodysplastic syndromes
title_full_unstemmed	The genomic landscape of pediatric myelodysplastic syndromes
title_sort	genomic landscape of pediatric myelodysplastic syndromes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-11-01
description	Myelodysplastic syndromes (MDS) are uncommon in children and have poor prognosis. Here, the authors interrogate the genomic landscape of MDS, confirming adult and paediatric MDS are separate diseases with disparate mechanisms, and highlighting that SAMD9/SAMD9L mutations represent a new class of MDS predisposition.
url	https://doi.org/10.1038/s41467-017-01590-5
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The genomic landscape of pediatric myelodysplastic syndromes

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