Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model.

Activation of store-operated calcium entry in airway smooth muscle cells: insight from a mathematical model.

Intracellular Ca(2+) dynamics of airway smooth muscle cells (ASMC) mediate ASMC contraction and proliferation, and thus play a key role in airway hyper-responsiveness (AHR) and remodelling in asthma. We evaluate the importance of store-operated Ca(2+) entry (SOCE) in these Ca(2+) dynamics by constru...

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Bibliographic Details
Main Authors: Huguette Croisier, Xiahui Tan, Jose F Perez-Zoghbi, Michael J Sanderson, James Sneyd, Bindi S Brook
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3723852?pdf=render

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