Recurrent Clostridium difficile colitis in elderly: the role of fidaxomicin
Clostridium difficile colitis is a substantial cause of in-hospital morbidity. Since the mortality attributable may be as high as 10%, a prompt and effective treatment is advisable. Fidaxomicin is a well-documented effective drug for the treatment of C. difficile colitis and it is particularly effec...
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doaj-d4892ad77501417fabb2ae92d0263e672020-11-25T00:57:32ZengSEEdClinical Management Issues1973-48322283-31372014-12-0181S131610.7175/cmi.v8i1S.954903Recurrent Clostridium difficile colitis in elderly: the role of fidaxomicinFrancesco Artom0Valerio Del Bono1Clinica Malattie infettive, IRCCS San Martino IST, GenovaClinica Malattie infettive, IRCCS San Martino IST, GenovaClostridium difficile colitis is a substantial cause of in-hospital morbidity. Since the mortality attributable may be as high as 10%, a prompt and effective treatment is advisable. Fidaxomicin is a well-documented effective drug for the treatment of C. difficile colitis and it is particularly effective in the treatment of recurrences. We report a case of a 92-year-old woman with prolonged hospitalization and recurrent episodes (three in a three-month period) of C. difficile diarrhea. Each episode initially responded to vancomycin. However, after the third episode fidaxomicin was given, with a sustained response (5 months without further episodes). In this patient fidaxomicin was safe and effective in treating recurrence of C. difficile colitis. The use of fidaxomicin as a therapy of first episode of C. difficile colitis should be considered for those patients with a predictable high risk of recurrent C. difficile colitis.https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/954ClostridiumVancomycinFidaxomicinRecurrenceColitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesco Artom Valerio Del Bono |
spellingShingle |
Francesco Artom Valerio Del Bono Recurrent Clostridium difficile colitis in elderly: the role of fidaxomicin Clinical Management Issues Clostridium Vancomycin Fidaxomicin Recurrence Colitis |
author_facet |
Francesco Artom Valerio Del Bono |
author_sort |
Francesco Artom |
title |
Recurrent Clostridium difficile colitis in elderly: the role of fidaxomicin |
title_short |
Recurrent Clostridium difficile colitis in elderly: the role of fidaxomicin |
title_full |
Recurrent Clostridium difficile colitis in elderly: the role of fidaxomicin |
title_fullStr |
Recurrent Clostridium difficile colitis in elderly: the role of fidaxomicin |
title_full_unstemmed |
Recurrent Clostridium difficile colitis in elderly: the role of fidaxomicin |
title_sort |
recurrent clostridium difficile colitis in elderly: the role of fidaxomicin |
publisher |
SEEd |
series |
Clinical Management Issues |
issn |
1973-4832 2283-3137 |
publishDate |
2014-12-01 |
description |
Clostridium difficile colitis is a substantial cause of in-hospital morbidity. Since the mortality attributable may be as high as 10%, a prompt and effective treatment is advisable. Fidaxomicin is a well-documented effective drug for the treatment of C. difficile colitis and it is particularly effective in the treatment of recurrences. We report a case of a 92-year-old woman with prolonged hospitalization and recurrent episodes (three in a three-month period) of C. difficile diarrhea. Each episode initially responded to vancomycin. However, after the third episode fidaxomicin was given, with a sustained response (5 months without further episodes). In this patient fidaxomicin was safe and effective in treating recurrence of C. difficile colitis. The use of fidaxomicin as a therapy of first episode of C. difficile colitis should be considered for those patients with a predictable high risk of recurrent C. difficile colitis. |
topic |
Clostridium Vancomycin Fidaxomicin Recurrence Colitis |
url |
https://journals.seedmedicalpublishers.com/index.php/cmi/article/view/954 |
work_keys_str_mv |
AT francescoartom recurrentclostridiumdifficilecolitisinelderlytheroleoffidaxomicin AT valeriodelbono recurrentclostridiumdifficilecolitisinelderlytheroleoffidaxomicin |
_version_ |
1725223694605746176 |