Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer
Abstract Background The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed methods of sampling. Methods To compare prospectively the diagnostic yield...
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doaj-d48b50360ef649198c9cab6095e152082020-11-25T03:58:19ZengBMCBMC Gastroenterology1471-230X2019-01-011911910.1186/s12876-018-0921-9Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancerRenáta Bor0Béla Vasas1Anna Fábián2Anita Bálint3Klaudia Farkas4Ágnes Milassin5László Czakó6Mariann Rutka7Tamás Molnár8Mónika Szűcs9László Tiszlavicz10László Kaizer11Sándor Hamar12Zoltán Szepes13First Department of Medicine, University of SzegedDepartment of Pathology, University of SzegedFirst Department of Medicine, University of SzegedFirst Department of Medicine, University of SzegedFirst Department of Medicine, University of SzegedFirst Department of Medicine, University of SzegedFirst Department of Medicine, University of SzegedFirst Department of Medicine, University of SzegedFirst Department of Medicine, University of SzegedDepartment of Medical Physics and Informatics, University of SzegedDepartment of Pathology, University of SzegedDepartment of Pathology, University of SzegedDepartment of Pathology, University of SzegedFirst Department of Medicine, University of SzegedAbstract Background The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed methods of sampling. Methods To compare prospectively the diagnostic yield of EUS-FNA samples obtained with slow-pull (SP) and with standard suction technique (SS). Results EUS-FNA sampling was diagnostic in 72 of 92 cases (78.3%). Diagnostic yield was 67.4% in the SS and 65.2% in the SP group. The number of smear pairs (1.84 vs. 3.56; p < 0.001) and blood contamination (1.50 vs. 2.19; p < 0.001) were significantly higher in the SS group, which resulted in lower rate of diagnostic samples (41.8% vs. 30.0%; p = 0.003). There was no difference in the cellularity (1.58 vs. 1.37; p = 0.2554), or in the sensitivity and specificity in the identification of malignancy between SP and SS subgroups (69.9, 100% vs. 73.5, 100%). Histological samples were obtained in 60 cases (with SP: 49 cases; with SS: 46 cases). There was no difference in the diagnostic yield of histological samples between the groups (63 and 58.7%). Conclusion The diagnostic yield, the cellularity of smears and the rate of acquiring sufficient histological material are similar in the SP and SS group, but due to lower bloodiness and decreased number of slides, the pathological diagnosis is faster and more cost-effective.http://link.springer.com/article/10.1186/s12876-018-0921-9Pancreatic cancerSamplingEndoscopic ultrasoundEndosonographyEUS-FNA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Renáta Bor Béla Vasas Anna Fábián Anita Bálint Klaudia Farkas Ágnes Milassin László Czakó Mariann Rutka Tamás Molnár Mónika Szűcs László Tiszlavicz László Kaizer Sándor Hamar Zoltán Szepes |
spellingShingle |
Renáta Bor Béla Vasas Anna Fábián Anita Bálint Klaudia Farkas Ágnes Milassin László Czakó Mariann Rutka Tamás Molnár Mónika Szűcs László Tiszlavicz László Kaizer Sándor Hamar Zoltán Szepes Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer BMC Gastroenterology Pancreatic cancer Sampling Endoscopic ultrasound Endosonography EUS-FNA |
author_facet |
Renáta Bor Béla Vasas Anna Fábián Anita Bálint Klaudia Farkas Ágnes Milassin László Czakó Mariann Rutka Tamás Molnár Mónika Szűcs László Tiszlavicz László Kaizer Sándor Hamar Zoltán Szepes |
author_sort |
Renáta Bor |
title |
Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer |
title_short |
Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer |
title_full |
Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer |
title_fullStr |
Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer |
title_full_unstemmed |
Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer |
title_sort |
prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer |
publisher |
BMC |
series |
BMC Gastroenterology |
issn |
1471-230X |
publishDate |
2019-01-01 |
description |
Abstract Background The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed methods of sampling. Methods To compare prospectively the diagnostic yield of EUS-FNA samples obtained with slow-pull (SP) and with standard suction technique (SS). Results EUS-FNA sampling was diagnostic in 72 of 92 cases (78.3%). Diagnostic yield was 67.4% in the SS and 65.2% in the SP group. The number of smear pairs (1.84 vs. 3.56; p < 0.001) and blood contamination (1.50 vs. 2.19; p < 0.001) were significantly higher in the SS group, which resulted in lower rate of diagnostic samples (41.8% vs. 30.0%; p = 0.003). There was no difference in the cellularity (1.58 vs. 1.37; p = 0.2554), or in the sensitivity and specificity in the identification of malignancy between SP and SS subgroups (69.9, 100% vs. 73.5, 100%). Histological samples were obtained in 60 cases (with SP: 49 cases; with SS: 46 cases). There was no difference in the diagnostic yield of histological samples between the groups (63 and 58.7%). Conclusion The diagnostic yield, the cellularity of smears and the rate of acquiring sufficient histological material are similar in the SP and SS group, but due to lower bloodiness and decreased number of slides, the pathological diagnosis is faster and more cost-effective. |
topic |
Pancreatic cancer Sampling Endoscopic ultrasound Endosonography EUS-FNA |
url |
http://link.springer.com/article/10.1186/s12876-018-0921-9 |
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