Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve?
Background. Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach target blood pressure (BP) ≤130/80 mm Hg. The aim of this study was to ident...
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2021-04-01
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doaj-d48f5a1cccf94c50b91fde104edfc6422021-03-29T09:23:08ZengWolters KluwerTransplantation Direct2373-87312021-04-0174e68810.1097/TXD.0000000000001142202104000-00011Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve?Mari O. Onsøien0Karsten Midtvedt, MD, PhD1Anna V. Reisæter, MD, PhD2Knut Aasarød, MD, PhD3Bård Waldum-Grevbo, MD, PhD4Bjørn Egil Vikse, MD, PhD5Bjørn Odvar Eriksen, MD, PhD6Anders Åsberg, PhD71 Faculty of Medicine, University of Oslo, Oslo, Norway.2 Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, Oslo, Norway.2 Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, Oslo, Norway.3 Norwegian Renal Registry, Oslo University Hospital-Rikshospitalet, Oslo, Norway.3 Norwegian Renal Registry, Oslo University Hospital-Rikshospitalet, Oslo, Norway.3 Norwegian Renal Registry, Oslo University Hospital-Rikshospitalet, Oslo, Norway.3 Norwegian Renal Registry, Oslo University Hospital-Rikshospitalet, Oslo, Norway.2 Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, Oslo, Norway.Background. Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach target blood pressure (BP) ≤130/80 mm Hg. The aim of this study was to identify the determinants of failure to achieve BP control. Methods. In conjunction with the 2018 annual data reporting, additional questions were added for recipients with BP >130/80 mm Hg (treating physician´s target BP for each patient, reasons for not achieving target, method of measurement). Results. Annual forms were received from 98% (3407 of 3486) of KTx recipients, with 1787 (52%) reporting a BP >130/80 mm Hg (“above-target” group). These recipients were older, mostly male, with higher body mass index and serum creatinine levels (P < 0.05) compared with patients with controlled hypertension (“on-target” group). Valid survey answers were available for 84% of the “above-target” group (Survresp) with no significant demographic differences versus nonresponders (Survnonresp). Among Survresp, 32% were under antihypertensive dose titration, whereas dose-limiting side effects were reported in 7%. Target BP was confirmed to 130/80 mm Hg for 60% of Survresp. In recipients for whom the treating physician set target BP >130/80 mm Hg, 51% did not reach these individual targets. The number of antihypertensive drugs was significantly higher in the “above-target” group versus “on-target” group (mean 2.1 ± 1.2 versus 1.8 ± 1.3) and 36% versus 25% used ≥3 antihypertensive drugs (P < 0.05). Automatic attended BP measurement was utilized by 51%. Conclusions. In KTx recipients, a higher BP target achievement seems possible, potentially in the range of 75%-80%.http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001142 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mari O. Onsøien Karsten Midtvedt, MD, PhD Anna V. Reisæter, MD, PhD Knut Aasarød, MD, PhD Bård Waldum-Grevbo, MD, PhD Bjørn Egil Vikse, MD, PhD Bjørn Odvar Eriksen, MD, PhD Anders Åsberg, PhD |
spellingShingle |
Mari O. Onsøien Karsten Midtvedt, MD, PhD Anna V. Reisæter, MD, PhD Knut Aasarød, MD, PhD Bård Waldum-Grevbo, MD, PhD Bjørn Egil Vikse, MD, PhD Bjørn Odvar Eriksen, MD, PhD Anders Åsberg, PhD Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? Transplantation Direct |
author_facet |
Mari O. Onsøien Karsten Midtvedt, MD, PhD Anna V. Reisæter, MD, PhD Knut Aasarød, MD, PhD Bård Waldum-Grevbo, MD, PhD Bjørn Egil Vikse, MD, PhD Bjørn Odvar Eriksen, MD, PhD Anders Åsberg, PhD |
author_sort |
Mari O. Onsøien |
title |
Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_short |
Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_full |
Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_fullStr |
Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_full_unstemmed |
Blood Pressure Treatment in Kidney Transplant Recipients—Can We Improve? |
title_sort |
blood pressure treatment in kidney transplant recipients—can we improve? |
publisher |
Wolters Kluwer |
series |
Transplantation Direct |
issn |
2373-8731 |
publishDate |
2021-04-01 |
description |
Background. Hypertension in kidney transplant (KTx) recipients is common, affecting both patient and graft survival. Annual data from the Norwegian Renal Registry reveal that <50% of adult (>18 y) KTx recipients reach target blood pressure (BP) ≤130/80 mm Hg. The aim of this study was to identify the determinants of failure to achieve BP control.
Methods. In conjunction with the 2018 annual data reporting, additional questions were added for recipients with BP >130/80 mm Hg (treating physician´s target BP for each patient, reasons for not achieving target, method of measurement).
Results. Annual forms were received from 98% (3407 of 3486) of KTx recipients, with 1787 (52%) reporting a BP >130/80 mm Hg (“above-target” group). These recipients were older, mostly male, with higher body mass index and serum creatinine levels (P < 0.05) compared with patients with controlled hypertension (“on-target” group). Valid survey answers were available for 84% of the “above-target” group (Survresp) with no significant demographic differences versus nonresponders (Survnonresp). Among Survresp, 32% were under antihypertensive dose titration, whereas dose-limiting side effects were reported in 7%. Target BP was confirmed to 130/80 mm Hg for 60% of Survresp. In recipients for whom the treating physician set target BP >130/80 mm Hg, 51% did not reach these individual targets. The number of antihypertensive drugs was significantly higher in the “above-target” group versus “on-target” group (mean 2.1 ± 1.2 versus 1.8 ± 1.3) and 36% versus 25% used ≥3 antihypertensive drugs (P < 0.05). Automatic attended BP measurement was utilized by 51%.
Conclusions. In KTx recipients, a higher BP target achievement seems possible, potentially in the range of 75%-80%. |
url |
http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001142 |
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