Clinical Characteristics, Treatment and Prognosis of 47 Non-small Cell Lung Cancer with Neuroendocrine Differentiation Patients
Background and objective Non-small cell lung cancer (NSCLC) with neuroendocrine differentiation (NED) was a new pathologic type and uncommon in clinics. The aim of this study is to observe the relationship between clinical pathologic characteristics, imagination, biological behavior and prognosis in...
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2019-08-01
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doaj-d495701c79a24f318b507be91669708d2020-11-24T21:27:43ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872019-08-0122850751110.3779/j.issn.1009-3419.2019.08.05Clinical Characteristics, Treatment and Prognosis of 47 Non-small Cell Lung Cancer with Neuroendocrine Differentiation PatientsXiaoyan LI0Huayan XU1Xun KANG2Jing ZHAO3Yi LIN4Shasha WANG5Xiaoqing LIU6Department of Oncologic Comprehensive Therapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Lung Cancer, The Fifth Medical Center, General Hospital of People's Liberation Army, Beijing 100071, ChinaDepartment of Oncologic Comprehensive Therapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Lung Cancer, The Fifth Medical Center, General Hospital of People's Liberation Army, Beijing 100071, ChinaDepartment of Oncologic Comprehensive Therapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of Lung Cancer, The Fifth Medical Center, General Hospital of People's Liberation Army, Beijing 100071, ChinaDepartment of Lung Cancer, The Fifth Medical Center, General Hospital of People's Liberation Army, Beijing 100071, ChinaBackground and objective Non-small cell lung cancer (NSCLC) with neuroendocrine differentiation (NED) was a new pathologic type and uncommon in clinics. The aim of this study is to observe the relationship between clinical pathologic characteristics, imagination, biological behavior and prognosis in NSCLC-NED. Methods The clinical data of 47 patients with NSCLC-NED admitted from January 2009 to November 2017 in the Fifth Medical Center of General Hospital of People's Liberation Army were collected. The demographic data and imaging characteristics were summarized. Pathological features, treatment and prognosis, analysis of the correlation between different factors and prognosis. Results Of the 47 patients with NSCLC-NED, the median age was 61 years (45 years-78 years), 38 males and 9 females; 37 were poorly differentiated cancer with NED, and 10 were middle differentiated cancer with NED; 2 cases of driving gene positive (1 case of EGFR sensitive mutation, 1 case of ALK fusion), objective response rate (ORR) of first-line chemotherapy was 34.5%, and median progression-free survival (PFS) was 4 months; the median overall survival (OS) was 11 months, and only 2 cases (4.2%, 2/47) of OS were over 2 years. Conclusion NSCLC-NED is different from simple NSCLC or pulmonary neuroendocrine tumors. Males, ≤70 years old, severely smoking, and patients with lower tumor differentiation often have NED, and most of them are stage IV. This type of patient-driven gene positive proportion is lower than the general adenocarcinoma population, less sensitive to chemotherapy, and the overall survival is shorter, indicating a poor prognosis.http://dx.doi.org/10.3779/j.issn.1009-3419.2019.08.05Lung neoplasmsNeuroendocrine differentiationDriver genePrognosis |
collection |
DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
Xiaoyan LI Huayan XU Xun KANG Jing ZHAO Yi LIN Shasha WANG Xiaoqing LIU |
spellingShingle |
Xiaoyan LI Huayan XU Xun KANG Jing ZHAO Yi LIN Shasha WANG Xiaoqing LIU Clinical Characteristics, Treatment and Prognosis of 47 Non-small Cell Lung Cancer with Neuroendocrine Differentiation Patients Chinese Journal of Lung Cancer Lung neoplasms Neuroendocrine differentiation Driver gene Prognosis |
author_facet |
Xiaoyan LI Huayan XU Xun KANG Jing ZHAO Yi LIN Shasha WANG Xiaoqing LIU |
author_sort |
Xiaoyan LI |
title |
Clinical Characteristics, Treatment and Prognosis of 47 Non-small Cell Lung Cancer with Neuroendocrine Differentiation Patients |
title_short |
Clinical Characteristics, Treatment and Prognosis of 47 Non-small Cell Lung Cancer with Neuroendocrine Differentiation Patients |
title_full |
Clinical Characteristics, Treatment and Prognosis of 47 Non-small Cell Lung Cancer with Neuroendocrine Differentiation Patients |
title_fullStr |
Clinical Characteristics, Treatment and Prognosis of 47 Non-small Cell Lung Cancer with Neuroendocrine Differentiation Patients |
title_full_unstemmed |
Clinical Characteristics, Treatment and Prognosis of 47 Non-small Cell Lung Cancer with Neuroendocrine Differentiation Patients |
title_sort |
clinical characteristics, treatment and prognosis of 47 non-small cell lung cancer with neuroendocrine differentiation patients |
publisher |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
series |
Chinese Journal of Lung Cancer |
issn |
1009-3419 1999-6187 |
publishDate |
2019-08-01 |
description |
Background and objective Non-small cell lung cancer (NSCLC) with neuroendocrine differentiation (NED) was a new pathologic type and uncommon in clinics. The aim of this study is to observe the relationship between clinical pathologic characteristics, imagination, biological behavior and prognosis in NSCLC-NED. Methods The clinical data of 47 patients with NSCLC-NED admitted from January 2009 to November 2017 in the Fifth Medical Center of General Hospital of People's Liberation Army were collected. The demographic data and imaging characteristics were summarized. Pathological features, treatment and prognosis, analysis of the correlation between different factors and prognosis. Results Of the 47 patients with NSCLC-NED, the median age was 61 years (45 years-78 years), 38 males and 9 females; 37 were poorly differentiated cancer with NED, and 10 were middle differentiated cancer with NED; 2 cases of driving gene positive (1 case of EGFR sensitive mutation, 1 case of ALK fusion), objective response rate (ORR) of first-line chemotherapy was 34.5%, and median progression-free survival (PFS) was 4 months; the median overall survival (OS) was 11 months, and only 2 cases (4.2%, 2/47) of OS were over 2 years. Conclusion NSCLC-NED is different from simple NSCLC or pulmonary neuroendocrine tumors. Males, ≤70 years old, severely smoking, and patients with lower tumor differentiation often have NED, and most of them are stage IV. This type of patient-driven gene positive proportion is lower than the general adenocarcinoma population, less sensitive to chemotherapy, and the overall survival is shorter, indicating a poor prognosis. |
topic |
Lung neoplasms Neuroendocrine differentiation Driver gene Prognosis |
url |
http://dx.doi.org/10.3779/j.issn.1009-3419.2019.08.05 |
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