Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case Report
Squamous cell carcinoma is one of the common malignancies among women, especially in the third and fourth decades of life. Human papillomavirus is the most important cause of squamous cell carcinoma among women worldwide. Early diagnosis and treatment of this carcinoma can prevent disease progres...
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Shiraz University of Medical Sciences
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doaj-d4a4f00a3c9d4e378a41fc36537f17862020-11-25T02:56:29ZengShiraz University of Medical SciencesMiddle East Journal of Cancer 2008-67092008-66872018-10-0194334338Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case ReportMalihe Hasanzadeh0Zohreh Yousefi1Amir Hosein Jafarian2Shohreh Saeed3Laya Shirinzadeh4Behrouz Davachi5Marjaneh Farazestanian6Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranGynecologist Oncologist, Fellowship of Gynecology Oncology, Mashhad, IranDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSquamous cell carcinoma is one of the common malignancies among women, especially in the third and fourth decades of life. Human papillomavirus is the most important cause of squamous cell carcinoma among women worldwide. Early diagnosis and treatment of this carcinoma can prevent disease progression. Herein, we present the case of a pregnant woman with squamous cell carcinoma. A 35-year-old pregnant woman referred to our clinic for cervical cerclage. During the procedure, the gynecological surgeon observed a suspicious lesion. Accordingly, cervical conization was performed and a squamous cell carcinoma lesion was confirmed by the pathology reports. Neoadjuvant chemotherapy was initiated for the patient during pregnancy. Radical hysterectomy and bilateral lymphadenectomy were conducted toward caesarean section. As the patient was a young fertile woman, the ovaries were saved. Although chemotherapy is not a standard treatment for cervical cancer in pregnancy, but neoadjuvant chemotherapy followed by radical hysterectomy and bilateral pelvic lymphadenectomy during cesarean section was a successful treatment in our patient.http://mejc.sums.ac.ir/index.php/mejc/article/view/776/396CervixNeoadjuvant chemotherapyPregnancySquamous cell carcinoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Malihe Hasanzadeh Zohreh Yousefi Amir Hosein Jafarian Shohreh Saeed Laya Shirinzadeh Behrouz Davachi Marjaneh Farazestanian |
spellingShingle |
Malihe Hasanzadeh Zohreh Yousefi Amir Hosein Jafarian Shohreh Saeed Laya Shirinzadeh Behrouz Davachi Marjaneh Farazestanian Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case Report Middle East Journal of Cancer Cervix Neoadjuvant chemotherapy Pregnancy Squamous cell carcinoma |
author_facet |
Malihe Hasanzadeh Zohreh Yousefi Amir Hosein Jafarian Shohreh Saeed Laya Shirinzadeh Behrouz Davachi Marjaneh Farazestanian |
author_sort |
Malihe Hasanzadeh |
title |
Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case Report |
title_short |
Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case Report |
title_full |
Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case Report |
title_fullStr |
Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case Report |
title_full_unstemmed |
Neoadjuvant Chemotherapy of Cervical Squamous Cell Carcinoma during Pregnancy: A Case Report |
title_sort |
neoadjuvant chemotherapy of cervical squamous cell carcinoma during pregnancy: a case report |
publisher |
Shiraz University of Medical Sciences |
series |
Middle East Journal of Cancer |
issn |
2008-6709 2008-6687 |
publishDate |
2018-10-01 |
description |
Squamous cell carcinoma is one of the common malignancies among women,
especially in the third and fourth decades of life. Human papillomavirus is the most
important cause of squamous cell carcinoma among women worldwide. Early diagnosis
and treatment of this carcinoma can prevent disease progression. Herein, we present
the case of a pregnant woman with squamous cell carcinoma.
A 35-year-old pregnant woman referred to our clinic for cervical cerclage. During
the procedure, the gynecological surgeon observed a suspicious lesion. Accordingly,
cervical conization was performed and a squamous cell carcinoma lesion was confirmed
by the pathology reports. Neoadjuvant chemotherapy was initiated for the patient
during pregnancy. Radical hysterectomy and bilateral lymphadenectomy were conducted
toward caesarean section. As the patient was a young fertile woman, the ovaries were
saved.
Although chemotherapy is not a standard treatment for cervical cancer in pregnancy,
but neoadjuvant chemotherapy followed by radical hysterectomy and bilateral pelvic
lymphadenectomy during cesarean section was a successful treatment in our patient. |
topic |
Cervix Neoadjuvant chemotherapy Pregnancy Squamous cell carcinoma |
url |
http://mejc.sums.ac.ir/index.php/mejc/article/view/776/396 |
work_keys_str_mv |
AT malihehasanzadeh neoadjuvantchemotherapyofcervicalsquamouscellcarcinomaduringpregnancyacasereport AT zohrehyousefi neoadjuvantchemotherapyofcervicalsquamouscellcarcinomaduringpregnancyacasereport AT amirhoseinjafarian neoadjuvantchemotherapyofcervicalsquamouscellcarcinomaduringpregnancyacasereport AT shohrehsaeed neoadjuvantchemotherapyofcervicalsquamouscellcarcinomaduringpregnancyacasereport AT layashirinzadeh neoadjuvantchemotherapyofcervicalsquamouscellcarcinomaduringpregnancyacasereport AT behrouzdavachi neoadjuvantchemotherapyofcervicalsquamouscellcarcinomaduringpregnancyacasereport AT marjanehfarazestanian neoadjuvantchemotherapyofcervicalsquamouscellcarcinomaduringpregnancyacasereport |
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