Parvovirus B19‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literature

Parvovirus B19‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literature

Abstract HLH is a catastrophic and likely underdiagnosed pathology with multiple triggers including infection. PVB19 can cause persistent marrow infection leading to HLH despite negative acute serologic markers making timely diagnosis difficult. Increased awareness of PVB19‐HLH is warranted given it...

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Main Authors: James Kalmuk, Sara Matar, Gong Feng, Edward Kilb, Ming Y. Lim
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Clinical Case Reports
Subjects:
bone marrow
hemophagocytic lymphohistiocytosis
Parvovirus B19
viral serology
Online Access:https://doi.org/10.1002/ccr3.2401
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spelling doaj-d4a7222627274018a5ba73b89c7d36632020-11-25T01:34:39ZengWileyClinical Case Reports2050-09042019-11-017112076208110.1002/ccr3.2401Parvovirus B19‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literatureJames Kalmuk0Sara Matar1Gong Feng2Edward Kilb3Ming Y. Lim4Department of Internal Medicine Medical University of South Carolina Charleston SC USADepartment of Hematology/Oncology Medical University of South Carolina Charleston SC USADepartment of Pathology and Laboratory Medicine Medical University of South Carolina Charleston SC USADepartment of Pulmonary and Critical Care Medicine Medical University of South Carolina Charleston SC USADepartment of Hematology/Oncology Medical University of South Carolina Charleston SC USAAbstract HLH is a catastrophic and likely underdiagnosed pathology with multiple triggers including infection. PVB19 can cause persistent marrow infection leading to HLH despite negative acute serologic markers making timely diagnosis difficult. Increased awareness of PVB19‐HLH is warranted given its potentially lethal nature and the careful interpretation required with serologic markers.https://doi.org/10.1002/ccr3.2401bone marrowhemophagocytic lymphohistiocytosisParvovirus B19viral serology
collection DOAJ
language English
format Article
sources DOAJ
author James Kalmuk
Sara Matar
Gong Feng
Edward Kilb
Ming Y. Lim
spellingShingle James Kalmuk
Sara Matar
Gong Feng
Edward Kilb
Ming Y. Lim
Parvovirus B19‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literature
Clinical Case Reports
bone marrow
hemophagocytic lymphohistiocytosis
Parvovirus B19
viral serology
author_facet James Kalmuk
Sara Matar
Gong Feng
Edward Kilb
Ming Y. Lim
author_sort James Kalmuk
title Parvovirus B19‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literature
title_short Parvovirus B19‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literature
title_full Parvovirus B19‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literature
title_fullStr Parvovirus B19‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literature
title_full_unstemmed Parvovirus B19‐induced hemophagocytic lymphohistiocytosis: Case report and review of the literature
title_sort parvovirus b19‐induced hemophagocytic lymphohistiocytosis: case report and review of the literature
publisher Wiley
series Clinical Case Reports
issn 2050-0904
publishDate 2019-11-01
description Abstract HLH is a catastrophic and likely underdiagnosed pathology with multiple triggers including infection. PVB19 can cause persistent marrow infection leading to HLH despite negative acute serologic markers making timely diagnosis difficult. Increased awareness of PVB19‐HLH is warranted given its potentially lethal nature and the careful interpretation required with serologic markers.
topic bone marrow
hemophagocytic lymphohistiocytosis
Parvovirus B19
viral serology
url https://doi.org/10.1002/ccr3.2401
work_keys_str_mv AT jameskalmuk parvovirusb19inducedhemophagocyticlymphohistiocytosiscasereportandreviewoftheliterature
AT saramatar parvovirusb19inducedhemophagocyticlymphohistiocytosiscasereportandreviewoftheliterature
AT gongfeng parvovirusb19inducedhemophagocyticlymphohistiocytosiscasereportandreviewoftheliterature
AT edwardkilb parvovirusb19inducedhemophagocyticlymphohistiocytosiscasereportandreviewoftheliterature
AT mingylim parvovirusb19inducedhemophagocyticlymphohistiocytosiscasereportandreviewoftheliterature
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