Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Chimeric antigen receptor (CAR)-based therapy for the treatment of liver cancer represents a promising therapeutic strategy. Here the authors show that CD147-targeting CAR-NK or CAR-T can induce anti-tumor activity against hepatocellular carcinoma in vitro and in vivo.

Bibliographic Details
Main Authors:	Hsiang-chi Tseng, Wei Xiong, Saiaditya Badeti, Yan Yang, Minh Ma, Ting Liu, Carlos A. Ramos, Gianpietro Dotti, Luke Fritzky, Jie-gen Jiang, Qing Yi, James Guarrera, Wei-Xing Zong, Chen Liu, Dongfang Liu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18444-2

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spelling	doaj-d4aefc73f7c342c4befc39c05ef9b9862021-09-26T11:47:53ZengNature Publishing GroupNature Communications2041-17232020-09-0111111510.1038/s41467-020-18444-2Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinomaHsiang-chi Tseng0Wei Xiong1Saiaditya Badeti2Yan Yang3Minh Ma4Ting Liu5Carlos A. Ramos6Gianpietro Dotti7Luke Fritzky8Jie-gen Jiang9Qing Yi10James Guarrera11Wei-Xing Zong12Chen Liu13Dongfang Liu14Department of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical SchoolDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical SchoolDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical SchoolDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical SchoolDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical SchoolDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical SchoolDepartment of Medicine, Baylor College of Medicine, One Baylor PlazaDepartment of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North CarolinaImaging core facility, Rutgers University-New Jersey Medical SchoolDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical SchoolCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center, Houston Methodist Research InstituteDepartment of Surgery, New Jersey Medical School, Rutgers-The State University of New JerseySchool of Pharmacy, Rutgers-The State University of New JerseyDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical SchoolDepartment of Pathology, Immunology and Laboratory Medicine, Rutgers University-New Jersey Medical SchoolChimeric antigen receptor (CAR)-based therapy for the treatment of liver cancer represents a promising therapeutic strategy. Here the authors show that CD147-targeting CAR-NK or CAR-T can induce anti-tumor activity against hepatocellular carcinoma in vitro and in vivo.https://doi.org/10.1038/s41467-020-18444-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hsiang-chi Tseng Wei Xiong Saiaditya Badeti Yan Yang Minh Ma Ting Liu Carlos A. Ramos Gianpietro Dotti Luke Fritzky Jie-gen Jiang Qing Yi James Guarrera Wei-Xing Zong Chen Liu Dongfang Liu
spellingShingle	Hsiang-chi Tseng Wei Xiong Saiaditya Badeti Yan Yang Minh Ma Ting Liu Carlos A. Ramos Gianpietro Dotti Luke Fritzky Jie-gen Jiang Qing Yi James Guarrera Wei-Xing Zong Chen Liu Dongfang Liu Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma Nature Communications
author_facet	Hsiang-chi Tseng Wei Xiong Saiaditya Badeti Yan Yang Minh Ma Ting Liu Carlos A. Ramos Gianpietro Dotti Luke Fritzky Jie-gen Jiang Qing Yi James Guarrera Wei-Xing Zong Chen Liu Dongfang Liu
author_sort	Hsiang-chi Tseng
title	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_short	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_full	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_fullStr	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_full_unstemmed	Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma
title_sort	efficacy of anti-cd147 chimeric antigen receptors targeting hepatocellular carcinoma
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	Chimeric antigen receptor (CAR)-based therapy for the treatment of liver cancer represents a promising therapeutic strategy. Here the authors show that CD147-targeting CAR-NK or CAR-T can induce anti-tumor activity against hepatocellular carcinoma in vitro and in vivo.
url	https://doi.org/10.1038/s41467-020-18444-2
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Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

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