Methods to Induce Chronic Ocular Hypertension
Glaucoma, a form of progressive optic neuropathy, is the second leading cause of blindness worldwide. Being a prominent disease affecting vision, substantial efforts are being made to better understand glaucoma pathogenesis and to develop novel treatment options including neuroprotective and neurore...
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doaj-d4b08e1dc5a84d899049bd2a978989072020-11-25T01:20:38ZengSAGE PublishingCell Transplantation0963-68971555-38922018-02-012710.1177/0963689717724793Methods to Induce Chronic Ocular HypertensionAshim Dey0Abby L. Manthey1Kin Chiu2Chi-Wai Do3School of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, ChinaLaboratory of Retina Brain Research, Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, ChinaSchool of Optometry, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, ChinaGlaucoma, a form of progressive optic neuropathy, is the second leading cause of blindness worldwide. Being a prominent disease affecting vision, substantial efforts are being made to better understand glaucoma pathogenesis and to develop novel treatment options including neuroprotective and neuroregenerative approaches. Cell transplantation has the potential to play a neuroprotective and/or neuroregenerative role for various ocular cell types (e.g., retinal cells, trabecular meshwork). Notably, glaucoma is often associated with elevated intraocular pressure, and over the past 2 decades, several rodent models of chronic ocular hypertension (COH) have been developed that reflect these changes in pressure. However, the underlying pathophysiology of glaucoma in these models and how they compare to the human condition remains unclear. This limitation is the primary barrier for using rodent models to develop novel therapies to manage glaucoma and glaucoma-related blindness. Here, we review the current techniques used to induce COH-related glaucoma in various rodent models, focusing on the strengths and weaknesses of the each, in order to provide a more complete understanding of how these models can be best utilized. To so do, we have separated them based on the target tissue (pre-trabecular, trabecular, and post-trabecular) in order to provide the reader with an encompassing reference describing the most appropriate rodent COH models for their research. We begin with an initial overview of the current use of these models in the evaluation of cell transplantation therapies.https://doi.org/10.1177/0963689717724793 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ashim Dey Abby L. Manthey Kin Chiu Chi-Wai Do |
spellingShingle |
Ashim Dey Abby L. Manthey Kin Chiu Chi-Wai Do Methods to Induce Chronic Ocular Hypertension Cell Transplantation |
author_facet |
Ashim Dey Abby L. Manthey Kin Chiu Chi-Wai Do |
author_sort |
Ashim Dey |
title |
Methods to Induce Chronic Ocular Hypertension |
title_short |
Methods to Induce Chronic Ocular Hypertension |
title_full |
Methods to Induce Chronic Ocular Hypertension |
title_fullStr |
Methods to Induce Chronic Ocular Hypertension |
title_full_unstemmed |
Methods to Induce Chronic Ocular Hypertension |
title_sort |
methods to induce chronic ocular hypertension |
publisher |
SAGE Publishing |
series |
Cell Transplantation |
issn |
0963-6897 1555-3892 |
publishDate |
2018-02-01 |
description |
Glaucoma, a form of progressive optic neuropathy, is the second leading cause of blindness worldwide. Being a prominent disease affecting vision, substantial efforts are being made to better understand glaucoma pathogenesis and to develop novel treatment options including neuroprotective and neuroregenerative approaches. Cell transplantation has the potential to play a neuroprotective and/or neuroregenerative role for various ocular cell types (e.g., retinal cells, trabecular meshwork). Notably, glaucoma is often associated with elevated intraocular pressure, and over the past 2 decades, several rodent models of chronic ocular hypertension (COH) have been developed that reflect these changes in pressure. However, the underlying pathophysiology of glaucoma in these models and how they compare to the human condition remains unclear. This limitation is the primary barrier for using rodent models to develop novel therapies to manage glaucoma and glaucoma-related blindness. Here, we review the current techniques used to induce COH-related glaucoma in various rodent models, focusing on the strengths and weaknesses of the each, in order to provide a more complete understanding of how these models can be best utilized. To so do, we have separated them based on the target tissue (pre-trabecular, trabecular, and post-trabecular) in order to provide the reader with an encompassing reference describing the most appropriate rodent COH models for their research. We begin with an initial overview of the current use of these models in the evaluation of cell transplantation therapies. |
url |
https://doi.org/10.1177/0963689717724793 |
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