Preoperative Oral Passiflora Incarnata Reduces Coughing Following Extubation: A Double Blind, Placebo-Controlled Study
Background: The incidence of coughing following extubation can result in a number of undesirable side effects. Therefore, the development of antitussive premedication may be desirable. Methods: In this study, 138 patients were randomized into two groups to receive either oral Passiflora incarnata (...
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Tehran University of Medical Sciences
2017-06-01
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doaj-d4b2f6e38e564126818807c72e253a4a2020-11-25T04:06:20ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492017-06-0133Preoperative Oral Passiflora Incarnata Reduces Coughing Following Extubation: A Double Blind, Placebo-Controlled StudyAlireza Saliminia0Omid Azimaraghi1Maryam Ghadimi2Naieemeh Kaafi Kang3Ali Movafegh4Department of Anesthesiology, Pain and Critical Care, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Anesthesiology, Pain and Critical Care, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Research Development Center, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Research Development Center, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Anesthesiology, Pain and Critical Care, Dr. Ali Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Background: The incidence of coughing following extubation can result in a number of undesirable side effects. Therefore, the development of antitussive premedication may be desirable. Methods: In this study, 138 patients were randomized into two groups to receive either oral Passiflora incarnata (500 mg, PassipyTM IranDarouk) (n = 69) or placebo (n = 69) as premedication, 120 min before surgery. After extubation, all patients were observed to record the incidence of coughing during a 15 minute period. Hemodynamic variables were recorded before induction of anesthesia, 1 minute following intubation, and 5 minutes after extubation. Results: The demographic characteristics of patients, ASA physical status, duration of surgery, hemodynamic variables were similar in the two groups. The incidence of cough following extubation was significantly lower in the passiflora group compared to the control group (P <0.001). Conclusion: In outpatient surgery, administration of oral Passiflora incarnata as a premedication reduces incidence of coughing following extubation. https://aacc.tums.ac.ir/index.php/aacc/article/view/118coughtracheal extubationpassiflora incarnate |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alireza Saliminia Omid Azimaraghi Maryam Ghadimi Naieemeh Kaafi Kang Ali Movafegh |
spellingShingle |
Alireza Saliminia Omid Azimaraghi Maryam Ghadimi Naieemeh Kaafi Kang Ali Movafegh Preoperative Oral Passiflora Incarnata Reduces Coughing Following Extubation: A Double Blind, Placebo-Controlled Study Archives of Anesthesia and Critical Care cough tracheal extubation passiflora incarnate |
author_facet |
Alireza Saliminia Omid Azimaraghi Maryam Ghadimi Naieemeh Kaafi Kang Ali Movafegh |
author_sort |
Alireza Saliminia |
title |
Preoperative Oral Passiflora Incarnata Reduces Coughing Following Extubation: A Double Blind, Placebo-Controlled Study |
title_short |
Preoperative Oral Passiflora Incarnata Reduces Coughing Following Extubation: A Double Blind, Placebo-Controlled Study |
title_full |
Preoperative Oral Passiflora Incarnata Reduces Coughing Following Extubation: A Double Blind, Placebo-Controlled Study |
title_fullStr |
Preoperative Oral Passiflora Incarnata Reduces Coughing Following Extubation: A Double Blind, Placebo-Controlled Study |
title_full_unstemmed |
Preoperative Oral Passiflora Incarnata Reduces Coughing Following Extubation: A Double Blind, Placebo-Controlled Study |
title_sort |
preoperative oral passiflora incarnata reduces coughing following extubation: a double blind, placebo-controlled study |
publisher |
Tehran University of Medical Sciences |
series |
Archives of Anesthesia and Critical Care |
issn |
2423-5849 |
publishDate |
2017-06-01 |
description |
Background: The incidence of coughing following extubation can result in a number of undesirable side effects. Therefore, the development of antitussive premedication may be desirable.
Methods: In this study, 138 patients were randomized into two groups to receive either oral Passiflora incarnata (500 mg, PassipyTM IranDarouk) (n = 69) or placebo (n = 69) as premedication, 120 min before surgery. After extubation, all patients were observed to record the incidence of coughing during a 15 minute period. Hemodynamic variables were recorded before induction of anesthesia, 1 minute following intubation, and 5 minutes after extubation.
Results: The demographic characteristics of patients, ASA physical status, duration of surgery, hemodynamic variables were similar in the two groups. The incidence of cough following extubation was significantly lower in the passiflora group compared to the control group (P <0.001).
Conclusion: In outpatient surgery, administration of oral Passiflora incarnata as a premedication reduces incidence of coughing following extubation.
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topic |
cough tracheal extubation passiflora incarnate |
url |
https://aacc.tums.ac.ir/index.php/aacc/article/view/118 |
work_keys_str_mv |
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