Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein

Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein

DNA polymerase III mis-insertion may, where not corrected by its 3′→ 5′ exonuclease or the mismatch repair (MMR) function, result in all possible non-cognate base pairs in DNA generating base substitutions. The most thermodynamically unstable base pair, the cytosine (C)⋅C mismatch, destabilizes adja...

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Bibliographic Details
Main Authors: Almaz Nigatu Tesfahun, Marina Alexeeva, Miglė Tomkuvienė, Aysha Arshad, Prashanna Guragain, Arne Klungland, Saulius Klimašauskas, Peter Ruoff, Svein Bjelland
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Microbiology
Subjects:
DNA base mismatch
cytosine:cytosine mismatch
thymine:thymine mismatch
base excision repair
DNA glycosylase
Escherichia coli Fpg
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.608839/full

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