Cellular Senescence in Renal and Urinary Tract Disorders
Cellular senescence is a state of cell cycle arrest induced by repetitive cell mitoses or different stresses, which is implicated in various physiological or pathological processes. The beneficial or adverse effects of senescent cells depend on their transitory or persistent state. Transient senesce...
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doaj-d4c6ada1fa414245b6e53033c72b64c82020-11-25T04:02:39ZengMDPI AGCells2073-44092020-11-0192420242010.3390/cells9112420Cellular Senescence in Renal and Urinary Tract DisordersYohan Santin0Philippe Lluel1Pascal Rischmann2Xavier Gamé3Jeanne Mialet-Perez4Angelo Parini5Institut des Maladies Métaboliques et Cardiovasculaires, Inserm, Université Paul Sabatier, UMR 1048—I2MC, 31432 Toulouse, FranceUrosphere SAS, Rue des Satellites, 31400 Toulouse, FranceDepartment of Urology, Kidney Transplantation and Andrology, Toulouse Rangueil University Hospital, 31432 Toulouse, FranceDepartment of Urology, Kidney Transplantation and Andrology, Toulouse Rangueil University Hospital, 31432 Toulouse, FranceInstitut des Maladies Métaboliques et Cardiovasculaires, Inserm, Université Paul Sabatier, UMR 1048—I2MC, 31432 Toulouse, FranceInstitut des Maladies Métaboliques et Cardiovasculaires, Inserm, Université Paul Sabatier, UMR 1048—I2MC, 31432 Toulouse, FranceCellular senescence is a state of cell cycle arrest induced by repetitive cell mitoses or different stresses, which is implicated in various physiological or pathological processes. The beneficial or adverse effects of senescent cells depend on their transitory or persistent state. Transient senescence has major beneficial roles promoting successful post-injury repair and inhibiting malignant transformation. On the other hand, persistent accumulation of senescent cells has been associated with chronic diseases and age-related illnesses like renal/urinary tract disorders. The deleterious effects of persistent senescent cells have been related, in part, to their senescence-associated secretory phenotype (SASP) characterized by the release of a variety of factors responsible for chronic inflammation, extracellular matrix adverse remodeling, and fibrosis. Recently, an increase in senescent cell burden has been reported in renal, prostate, and bladder disorders. In this review, we will summarize the molecular mechanisms of senescence and their implication in renal and urinary tract diseases. We will also discuss the differential impacts of transient versus persistent status of cellular senescence, as well as the therapeutic potential of senescent cell targeting in these diseases.https://www.mdpi.com/2073-4409/9/11/2420senescenceagingSASPchronic kidney diseaseurogenital disorders |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yohan Santin Philippe Lluel Pascal Rischmann Xavier Gamé Jeanne Mialet-Perez Angelo Parini |
spellingShingle |
Yohan Santin Philippe Lluel Pascal Rischmann Xavier Gamé Jeanne Mialet-Perez Angelo Parini Cellular Senescence in Renal and Urinary Tract Disorders Cells senescence aging SASP chronic kidney disease urogenital disorders |
author_facet |
Yohan Santin Philippe Lluel Pascal Rischmann Xavier Gamé Jeanne Mialet-Perez Angelo Parini |
author_sort |
Yohan Santin |
title |
Cellular Senescence in Renal and Urinary Tract Disorders |
title_short |
Cellular Senescence in Renal and Urinary Tract Disorders |
title_full |
Cellular Senescence in Renal and Urinary Tract Disorders |
title_fullStr |
Cellular Senescence in Renal and Urinary Tract Disorders |
title_full_unstemmed |
Cellular Senescence in Renal and Urinary Tract Disorders |
title_sort |
cellular senescence in renal and urinary tract disorders |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-11-01 |
description |
Cellular senescence is a state of cell cycle arrest induced by repetitive cell mitoses or different stresses, which is implicated in various physiological or pathological processes. The beneficial or adverse effects of senescent cells depend on their transitory or persistent state. Transient senescence has major beneficial roles promoting successful post-injury repair and inhibiting malignant transformation. On the other hand, persistent accumulation of senescent cells has been associated with chronic diseases and age-related illnesses like renal/urinary tract disorders. The deleterious effects of persistent senescent cells have been related, in part, to their senescence-associated secretory phenotype (SASP) characterized by the release of a variety of factors responsible for chronic inflammation, extracellular matrix adverse remodeling, and fibrosis. Recently, an increase in senescent cell burden has been reported in renal, prostate, and bladder disorders. In this review, we will summarize the molecular mechanisms of senescence and their implication in renal and urinary tract diseases. We will also discuss the differential impacts of transient versus persistent status of cellular senescence, as well as the therapeutic potential of senescent cell targeting in these diseases. |
topic |
senescence aging SASP chronic kidney disease urogenital disorders |
url |
https://www.mdpi.com/2073-4409/9/11/2420 |
work_keys_str_mv |
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