Platinum(IV) Complexes of <i>trans</i>-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance

Platinum(IV) Complexes of <i>trans</i>-1,2-diamino-4-cyclohexene: Prodrugs Affording an Oxaliplatin Analogue that Overcomes Cancer Resistance

Six platinum(IV) compounds derived from an oxaliplatin analogue containing the unsaturated cyclic diamine <i>trans</i>-1,2-diamino-4-cyclohexene (DACHEX), in place of the 1,2-diaminocyclohexane, and a range of axial ligands, were synthesized and characterized. The derivatives with at lea...

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Bibliographic Details
Main Authors: Paride Papadia, Katia Micoli, Alessandra Barbanente, Nicoletta Ditaranto, James D. Hoeschele, Giovanni Natile, Cristina Marzano, Valentina Gandin, Nicola Margiotta
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
cisplatin
oxaliplatin
anticancer drugs
platinum(IV) prodrugs
<i>trans</i>-1,2-diamino-4-cyclohexene
Online Access:https://www.mdpi.com/1422-0067/21/7/2325

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