Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease
FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated wi...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2014-03-01
|
Series: | Nutrients |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6643/6/3/1029 |
id |
doaj-d4de564eed84454ca9cea8a2950b9bd8 |
---|---|
record_format |
Article |
spelling |
doaj-d4de564eed84454ca9cea8a2950b9bd82020-11-25T02:49:56ZengMDPI AGNutrients2072-66432014-03-01631029103710.3390/nu6031029nu6031029Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney DiseaseDomenico Santoro0Giorgia Gagliostro1Angela Alibrandi2Riccardo Ientile3Guido Bellinghieri4Vincenzo Savica5Michele Buemi6Daniela Caccamo7Department of Clinical and Experimental Medicine, University of Messina, Messina 98123, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Messina 98123, ItalyDepartment of Economical, Business and Environmental Sciences and Quantitative Methods, University of Messina, Messina 98123, ItalyDepartment of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina 98123, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Messina 98123, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Messina 98123, ItalyDepartment of Clinical and Experimental Medicine, University of Messina, Messina 98123, ItalyDepartment of Biochemical, Physiological and Nutritional Sciences, University of Messina, Messina 98123, ItalyFokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) not yet on dialysis. One hundred and forty five patients with CKD stage 3 were genotyped for FokI and BsmI VDR polymorphisms, in order to assess the relationships between these VDR polymorphisms, some markers of mineral bone disorders, and LVH measured by echocardiography. Patients bearing either the Ff heterozygous or FF homozygous genotype had significantly higher PTH values than those bearing the ff genotype. The relationships between VDR genotypes and LVH revealed a highly significant association of the BsmI Bb heterozygous genotype with LVH. In patients with CKD stage 3 BsmI B allele was independently related to LVH. Since LVH is a frequent finding in dialysis population due to several mechanisms, the presence of the same relationship in patients with CKD strengthens the hypothesis that alterations of vitamin D signaling are implicated in LVH development in patients with renal diseases.http://www.mdpi.com/2072-6643/6/3/1029vitamin D receptorgene polymorphismsleft ventricular hypertrophyparathormonechronic kidney disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Domenico Santoro Giorgia Gagliostro Angela Alibrandi Riccardo Ientile Guido Bellinghieri Vincenzo Savica Michele Buemi Daniela Caccamo |
spellingShingle |
Domenico Santoro Giorgia Gagliostro Angela Alibrandi Riccardo Ientile Guido Bellinghieri Vincenzo Savica Michele Buemi Daniela Caccamo Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease Nutrients vitamin D receptor gene polymorphisms left ventricular hypertrophy parathormone chronic kidney disease |
author_facet |
Domenico Santoro Giorgia Gagliostro Angela Alibrandi Riccardo Ientile Guido Bellinghieri Vincenzo Savica Michele Buemi Daniela Caccamo |
author_sort |
Domenico Santoro |
title |
Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease |
title_short |
Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease |
title_full |
Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease |
title_fullStr |
Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease |
title_full_unstemmed |
Vitamin D Receptor Gene Polymorphism and Left Ventricular Hypertrophy in Chronic Kidney Disease |
title_sort |
vitamin d receptor gene polymorphism and left ventricular hypertrophy in chronic kidney disease |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2014-03-01 |
description |
FokI and BsmI polymorphisms of vitamin D receptor (VDR) gene are regarded as reliable markers of disturbed vitamin D signaling pathway. Left ventricular hypertrophy (LVH) is a strong cardiovascular risk marker in end stage renal disease (ESRD) patients. Since BsmI polymorphism has been associated with LVH in ESRD patients, we addressed this study in patients with chronic kidney disease (CKD) not yet on dialysis. One hundred and forty five patients with CKD stage 3 were genotyped for FokI and BsmI VDR polymorphisms, in order to assess the relationships between these VDR polymorphisms, some markers of mineral bone disorders, and LVH measured by echocardiography. Patients bearing either the Ff heterozygous or FF homozygous genotype had significantly higher PTH values than those bearing the ff genotype. The relationships between VDR genotypes and LVH revealed a highly significant association of the BsmI Bb heterozygous genotype with LVH. In patients with CKD stage 3 BsmI B allele was independently related to LVH. Since LVH is a frequent finding in dialysis population due to several mechanisms, the presence of the same relationship in patients with CKD strengthens the hypothesis that alterations of vitamin D signaling are implicated in LVH development in patients with renal diseases. |
topic |
vitamin D receptor gene polymorphisms left ventricular hypertrophy parathormone chronic kidney disease |
url |
http://www.mdpi.com/2072-6643/6/3/1029 |
work_keys_str_mv |
AT domenicosantoro vitamindreceptorgenepolymorphismandleftventricularhypertrophyinchronickidneydisease AT giorgiagagliostro vitamindreceptorgenepolymorphismandleftventricularhypertrophyinchronickidneydisease AT angelaalibrandi vitamindreceptorgenepolymorphismandleftventricularhypertrophyinchronickidneydisease AT riccardoientile vitamindreceptorgenepolymorphismandleftventricularhypertrophyinchronickidneydisease AT guidobellinghieri vitamindreceptorgenepolymorphismandleftventricularhypertrophyinchronickidneydisease AT vincenzosavica vitamindreceptorgenepolymorphismandleftventricularhypertrophyinchronickidneydisease AT michelebuemi vitamindreceptorgenepolymorphismandleftventricularhypertrophyinchronickidneydisease AT danielacaccamo vitamindreceptorgenepolymorphismandleftventricularhypertrophyinchronickidneydisease |
_version_ |
1724741294553563136 |