General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation
Pain has been considered as a concept of sensation that we feel as a reaction to the stimulus of our surrounding, putting us in harm’s way and acting as a form of defense mechanism that our body has permanently installed into its system. However, pain leads to a huge chunk of finances with...
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doaj-d4e0c173c2ae4d2b94ca429439af01752020-11-24T21:08:05ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-07-01198216410.3390/ijms19082164ijms19082164General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain RegulationMun Fei Yam0Yean Chun Loh1Chu Shan Tan2Siti Khadijah Adam3Nizar Abdul Manan4Rusliza Basir5Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, MalaysiaDepartment of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, MalaysiaDepartment of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, MalaysiaDepartment of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, MalaysiaDepartment of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, MalaysiaDepartment of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, MalaysiaPain has been considered as a concept of sensation that we feel as a reaction to the stimulus of our surrounding, putting us in harm’s way and acting as a form of defense mechanism that our body has permanently installed into its system. However, pain leads to a huge chunk of finances within the healthcare system with continuous rehabilitation of patients with adverse pain sensations, which might reduce not only their quality of life but also their productivity at work setting back the pace of our economy. It may not look like a huge deal but factor in pain as an issue for majority of us, it becomes an economical burden. Although pain has been researched into and understood by numerous researches, from its definition, mechanism of action to its inhibition in hopes of finding an absolute solution for victims of pain, the pathways of pain sensation, neurotransmitters involved in producing such a sensation are not comprehensively reviewed. Therefore, this review article aims to put in place a thorough understanding of major pain conditions that we experience—nociceptive, inflammatory and physiologically dysfunction, such as neuropathic pain and its modulation and feedback systems. Moreover, the complete mechanism of conduction is compiled within this article, elucidating understandings from various researches and breakthroughs.http://www.mdpi.com/1422-0067/19/8/2164pain sensitizationneurotransmittersnociceptiveinflammatoryneuropathicpresynaptic and postsynapticpain transmissionneuronssynaptic transmission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mun Fei Yam Yean Chun Loh Chu Shan Tan Siti Khadijah Adam Nizar Abdul Manan Rusliza Basir |
spellingShingle |
Mun Fei Yam Yean Chun Loh Chu Shan Tan Siti Khadijah Adam Nizar Abdul Manan Rusliza Basir General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation International Journal of Molecular Sciences pain sensitization neurotransmitters nociceptive inflammatory neuropathic presynaptic and postsynaptic pain transmission neurons synaptic transmission |
author_facet |
Mun Fei Yam Yean Chun Loh Chu Shan Tan Siti Khadijah Adam Nizar Abdul Manan Rusliza Basir |
author_sort |
Mun Fei Yam |
title |
General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation |
title_short |
General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation |
title_full |
General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation |
title_fullStr |
General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation |
title_full_unstemmed |
General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation |
title_sort |
general pathways of pain sensation and the major neurotransmitters involved in pain regulation |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-07-01 |
description |
Pain has been considered as a concept of sensation that we feel as a reaction to the stimulus of our surrounding, putting us in harm’s way and acting as a form of defense mechanism that our body has permanently installed into its system. However, pain leads to a huge chunk of finances within the healthcare system with continuous rehabilitation of patients with adverse pain sensations, which might reduce not only their quality of life but also their productivity at work setting back the pace of our economy. It may not look like a huge deal but factor in pain as an issue for majority of us, it becomes an economical burden. Although pain has been researched into and understood by numerous researches, from its definition, mechanism of action to its inhibition in hopes of finding an absolute solution for victims of pain, the pathways of pain sensation, neurotransmitters involved in producing such a sensation are not comprehensively reviewed. Therefore, this review article aims to put in place a thorough understanding of major pain conditions that we experience—nociceptive, inflammatory and physiologically dysfunction, such as neuropathic pain and its modulation and feedback systems. Moreover, the complete mechanism of conduction is compiled within this article, elucidating understandings from various researches and breakthroughs. |
topic |
pain sensitization neurotransmitters nociceptive inflammatory neuropathic presynaptic and postsynaptic pain transmission neurons synaptic transmission |
url |
http://www.mdpi.com/1422-0067/19/8/2164 |
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