Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms
There is an increasing trend in the incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) worldwide. The aim of the present study was to identify the prognostic factors of patients with GEP-NENs. A cross-sectional, retrospective chart review study was conducted among patients with...
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doaj-d4e8c065ec304aaeaec878e7e3a614e02020-11-25T01:14:09ZengWileyKaohsiung Journal of Medical Sciences1607-551X2018-11-013411650656Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasmsPao-Yuan Huang0Kai-Lung Tsai1Chih-Ming Liang2Wei-Chen Tai3Kun-Ming Rau4Keng-Liang Wu5Chao-Cheng Huang6Seng-Kee Chuah7Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Colon and Rectal Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDivision of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Pathology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Corresponding author. Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Song District, Kaohsiung 833, Taiwan.There is an increasing trend in the incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) worldwide. The aim of the present study was to identify the prognostic factors of patients with GEP-NENs. A cross-sectional, retrospective chart review study was conducted among patients with pathologically proven GEP-NENs between January 2003 and December 2016 at Kaohsiung Chung-Gung Memorial Hospital. A total of 97 patients who met the inclusion criteria were included (male/female = 56/41, age: 57.7 ± 15.4 years). The presentation, clinical characteristics, and disease outcomes were reviewed and analyzed. The most common primary site of the GEP-NENs was the rectum (49.5%), followed by the pancreas (17.5%), duodenum (11.3%), stomach (10.3%), colon (6.2%), and appendix (5.2%), and most GEP-NENs were hormonally nonfunctional (94.8%). There were 56 tumors classified as G1 neuroendocrine tumors (NETs), 9 as G2 NETs, and 14 as G3 neuroendocrine carcinoma (NEC). Metastasis was found in 15 patients (15%). Curative treatments, such as surgery or endoscopic resection, were performed in 83.5% of patients (n = 81). The mean overall survival duration was 107.2 ± 7.8 months. The estimated 3- and 5-year overall survival rates for all patients were 84% and 82%, respectively. Logistic regression analysis showed that large tumor size, non-rectal NENs, high histopathological grading, lymphatic metastases and distant metastases were associated with poor survival. This study suggested that the presence of lymphatic or distant metastases at diagnosis is an independent risk factor for poor prognosis in patients with GEP-NENs. Keywords: Gastroenteropancreatic neuroendocrine tumors, Clinical outcome, Prognostic factorshttp://www.sciencedirect.com/science/article/pii/S1607551X18301281 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pao-Yuan Huang Kai-Lung Tsai Chih-Ming Liang Wei-Chen Tai Kun-Ming Rau Keng-Liang Wu Chao-Cheng Huang Seng-Kee Chuah |
spellingShingle |
Pao-Yuan Huang Kai-Lung Tsai Chih-Ming Liang Wei-Chen Tai Kun-Ming Rau Keng-Liang Wu Chao-Cheng Huang Seng-Kee Chuah Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms Kaohsiung Journal of Medical Sciences |
author_facet |
Pao-Yuan Huang Kai-Lung Tsai Chih-Ming Liang Wei-Chen Tai Kun-Ming Rau Keng-Liang Wu Chao-Cheng Huang Seng-Kee Chuah |
author_sort |
Pao-Yuan Huang |
title |
Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms |
title_short |
Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms |
title_full |
Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms |
title_fullStr |
Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms |
title_full_unstemmed |
Prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms |
title_sort |
prognostic factors of patients with gastroenteropancreatic neuroendocrine neoplasms |
publisher |
Wiley |
series |
Kaohsiung Journal of Medical Sciences |
issn |
1607-551X |
publishDate |
2018-11-01 |
description |
There is an increasing trend in the incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) worldwide. The aim of the present study was to identify the prognostic factors of patients with GEP-NENs. A cross-sectional, retrospective chart review study was conducted among patients with pathologically proven GEP-NENs between January 2003 and December 2016 at Kaohsiung Chung-Gung Memorial Hospital. A total of 97 patients who met the inclusion criteria were included (male/female = 56/41, age: 57.7 ± 15.4 years). The presentation, clinical characteristics, and disease outcomes were reviewed and analyzed. The most common primary site of the GEP-NENs was the rectum (49.5%), followed by the pancreas (17.5%), duodenum (11.3%), stomach (10.3%), colon (6.2%), and appendix (5.2%), and most GEP-NENs were hormonally nonfunctional (94.8%). There were 56 tumors classified as G1 neuroendocrine tumors (NETs), 9 as G2 NETs, and 14 as G3 neuroendocrine carcinoma (NEC). Metastasis was found in 15 patients (15%). Curative treatments, such as surgery or endoscopic resection, were performed in 83.5% of patients (n = 81). The mean overall survival duration was 107.2 ± 7.8 months. The estimated 3- and 5-year overall survival rates for all patients were 84% and 82%, respectively. Logistic regression analysis showed that large tumor size, non-rectal NENs, high histopathological grading, lymphatic metastases and distant metastases were associated with poor survival. This study suggested that the presence of lymphatic or distant metastases at diagnosis is an independent risk factor for poor prognosis in patients with GEP-NENs. Keywords: Gastroenteropancreatic neuroendocrine tumors, Clinical outcome, Prognostic factors |
url |
http://www.sciencedirect.com/science/article/pii/S1607551X18301281 |
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