The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus
Background/Aims: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-05-01
|
Series: | Heliyon |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844021008768 |
id |
doaj-d4f83fa0be584e61b5a832a79722e7be |
---|---|
record_format |
Article |
spelling |
doaj-d4f83fa0be584e61b5a832a79722e7be2021-06-03T14:44:51ZengElsevierHeliyon2405-84402021-05-0175e06773The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitusDante S. Harbuwono0Brama I. Sazli1Farid Kurniawan2Budiman Darmowidjojo3Sukamto Koesnoe4Dicky L. Tahapary5Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Jakarta, Indonesia; Corresponding author.Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Jakarta, IndonesiaDivision of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Jakarta, IndonesiaDivision of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Jakarta, IndonesiaDivision of Allergy and Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, IndonesiaDivision of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Jakarta, IndonesiaBackground/Aims: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This was a prospective study done among 37 patients with T2DM from Internal Medicine Polyclinic in a hospital in Jakarta, Indonesia. Anthropometric data as well as Hemoglobin A1c (HbA1c), Fasting Blood Glucose (FBG), and Fetuin-A levels of the subjects were measured in three time points: before, during, and after Ramadan fasting. A bivariate analysis was done to see the effect of Ramadan fasting on those parameters. Results: Ramadan fasting reduced Fetuin-A levels [median (minimum–maximum), 5.35 (2.91–7.81) vs. 3.22 (2.35–5.60) mg/dl; p = 0.039] four weeks after the end of Ramadan compared to pre-Ramadan. After two weeks of Ramadan fasting, we found a significant reduction in body weight, BMI, FBG, and HbA1c levels which rebounded to baseline level after Ramadan. Conclusion: Ramadan fasting was associated with a significant decrease in Fetuin-A level post Ramadan.http://www.sciencedirect.com/science/article/pii/S2405844021008768Ramadan fastingDiabetes mellitusFetuin-AInsulin resistanceGlycoprotein |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dante S. Harbuwono Brama I. Sazli Farid Kurniawan Budiman Darmowidjojo Sukamto Koesnoe Dicky L. Tahapary |
spellingShingle |
Dante S. Harbuwono Brama I. Sazli Farid Kurniawan Budiman Darmowidjojo Sukamto Koesnoe Dicky L. Tahapary The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus Heliyon Ramadan fasting Diabetes mellitus Fetuin-A Insulin resistance Glycoprotein |
author_facet |
Dante S. Harbuwono Brama I. Sazli Farid Kurniawan Budiman Darmowidjojo Sukamto Koesnoe Dicky L. Tahapary |
author_sort |
Dante S. Harbuwono |
title |
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus |
title_short |
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus |
title_full |
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus |
title_fullStr |
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus |
title_full_unstemmed |
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus |
title_sort |
impact of ramadan fasting on fetuin-a level in type 2 diabetes mellitus |
publisher |
Elsevier |
series |
Heliyon |
issn |
2405-8440 |
publishDate |
2021-05-01 |
description |
Background/Aims: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This was a prospective study done among 37 patients with T2DM from Internal Medicine Polyclinic in a hospital in Jakarta, Indonesia. Anthropometric data as well as Hemoglobin A1c (HbA1c), Fasting Blood Glucose (FBG), and Fetuin-A levels of the subjects were measured in three time points: before, during, and after Ramadan fasting. A bivariate analysis was done to see the effect of Ramadan fasting on those parameters. Results: Ramadan fasting reduced Fetuin-A levels [median (minimum–maximum), 5.35 (2.91–7.81) vs. 3.22 (2.35–5.60) mg/dl; p = 0.039] four weeks after the end of Ramadan compared to pre-Ramadan. After two weeks of Ramadan fasting, we found a significant reduction in body weight, BMI, FBG, and HbA1c levels which rebounded to baseline level after Ramadan. Conclusion: Ramadan fasting was associated with a significant decrease in Fetuin-A level post Ramadan. |
topic |
Ramadan fasting Diabetes mellitus Fetuin-A Insulin resistance Glycoprotein |
url |
http://www.sciencedirect.com/science/article/pii/S2405844021008768 |
work_keys_str_mv |
AT dantesharbuwono theimpactoframadanfastingonfetuinalevelintype2diabetesmellitus AT bramaisazli theimpactoframadanfastingonfetuinalevelintype2diabetesmellitus AT faridkurniawan theimpactoframadanfastingonfetuinalevelintype2diabetesmellitus AT budimandarmowidjojo theimpactoframadanfastingonfetuinalevelintype2diabetesmellitus AT sukamtokoesnoe theimpactoframadanfastingonfetuinalevelintype2diabetesmellitus AT dickyltahapary theimpactoframadanfastingonfetuinalevelintype2diabetesmellitus AT dantesharbuwono impactoframadanfastingonfetuinalevelintype2diabetesmellitus AT bramaisazli impactoframadanfastingonfetuinalevelintype2diabetesmellitus AT faridkurniawan impactoframadanfastingonfetuinalevelintype2diabetesmellitus AT budimandarmowidjojo impactoframadanfastingonfetuinalevelintype2diabetesmellitus AT sukamtokoesnoe impactoframadanfastingonfetuinalevelintype2diabetesmellitus AT dickyltahapary impactoframadanfastingonfetuinalevelintype2diabetesmellitus |
_version_ |
1721399294506827776 |