Natural Melanin-Based Nanoparticles With Combined Chemo/Photothermal/Photodynamic Effect Induce Immunogenic Cell Death (ICD) on Tumor
Melanin, as a natural product, has been used as an extraordinary ingredient for nanomedicine due to its great biocompatibility and light responsive property. In this study, polydopamine (PDA), an analog of melanin, was extracted from dopamine and encapsulated with doxorubicin (DOX). The as-prepared...
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2021-02-01
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doaj-d4fd31f01211456ea8fd41f45f0e02c22021-02-19T05:25:30ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-02-01910.3389/fbioe.2021.635858635858Natural Melanin-Based Nanoparticles With Combined Chemo/Photothermal/Photodynamic Effect Induce Immunogenic Cell Death (ICD) on TumorDing Liu0Huilin Huang1Bingxia Zhao2Weihong Guo3Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaGuangzhou Key Laboratory of Tumor Immunology Research, School of Basic Medical Sciences, Cancer Research Institute, Southern Medical University, Guangzhou, ChinaDepartment of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaMelanin, as a natural product, has been used as an extraordinary ingredient for nanomedicine due to its great biocompatibility and light responsive property. In this study, polydopamine (PDA), an analog of melanin, was extracted from dopamine and encapsulated with doxorubicin (DOX). The as-prepared nanoparticles (NPs) with good stability, great biosafety and high near infrared (NIR) responsive property ameliorated the cell uptake of DOX in OS-RC-2/ADR cells, exhibited synergistic chemo/photothermal (PTT)/photodynamic (PDT) effects, induced the release of damage associated molecular patterns (DAMPs), and finally, led to immunogenic cell death (ICD). In general, it was suggested that PDA-DOX NPs with NIR irradiation could serve as a promising agent for tumor therapy.https://www.frontiersin.org/articles/10.3389/fbioe.2021.635858/fullimmunogenic cell deathmelaninnatural productphotothermalphotodynamicROS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ding Liu Huilin Huang Bingxia Zhao Weihong Guo |
spellingShingle |
Ding Liu Huilin Huang Bingxia Zhao Weihong Guo Natural Melanin-Based Nanoparticles With Combined Chemo/Photothermal/Photodynamic Effect Induce Immunogenic Cell Death (ICD) on Tumor Frontiers in Bioengineering and Biotechnology immunogenic cell death melanin natural product photothermal photodynamic ROS |
author_facet |
Ding Liu Huilin Huang Bingxia Zhao Weihong Guo |
author_sort |
Ding Liu |
title |
Natural Melanin-Based Nanoparticles With Combined Chemo/Photothermal/Photodynamic Effect Induce Immunogenic Cell Death (ICD) on Tumor |
title_short |
Natural Melanin-Based Nanoparticles With Combined Chemo/Photothermal/Photodynamic Effect Induce Immunogenic Cell Death (ICD) on Tumor |
title_full |
Natural Melanin-Based Nanoparticles With Combined Chemo/Photothermal/Photodynamic Effect Induce Immunogenic Cell Death (ICD) on Tumor |
title_fullStr |
Natural Melanin-Based Nanoparticles With Combined Chemo/Photothermal/Photodynamic Effect Induce Immunogenic Cell Death (ICD) on Tumor |
title_full_unstemmed |
Natural Melanin-Based Nanoparticles With Combined Chemo/Photothermal/Photodynamic Effect Induce Immunogenic Cell Death (ICD) on Tumor |
title_sort |
natural melanin-based nanoparticles with combined chemo/photothermal/photodynamic effect induce immunogenic cell death (icd) on tumor |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Bioengineering and Biotechnology |
issn |
2296-4185 |
publishDate |
2021-02-01 |
description |
Melanin, as a natural product, has been used as an extraordinary ingredient for nanomedicine due to its great biocompatibility and light responsive property. In this study, polydopamine (PDA), an analog of melanin, was extracted from dopamine and encapsulated with doxorubicin (DOX). The as-prepared nanoparticles (NPs) with good stability, great biosafety and high near infrared (NIR) responsive property ameliorated the cell uptake of DOX in OS-RC-2/ADR cells, exhibited synergistic chemo/photothermal (PTT)/photodynamic (PDT) effects, induced the release of damage associated molecular patterns (DAMPs), and finally, led to immunogenic cell death (ICD). In general, it was suggested that PDA-DOX NPs with NIR irradiation could serve as a promising agent for tumor therapy. |
topic |
immunogenic cell death melanin natural product photothermal photodynamic ROS |
url |
https://www.frontiersin.org/articles/10.3389/fbioe.2021.635858/full |
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