BRCA2 mutations and triple-negative breast cancer.
Recently, BRCA1 germline mutations were found in a high proportion (14-34%) of patients with triple-negative breast cancer (TNBC). BRCA2 was either not analyzed or showed much lower mutation frequencies. Therefore, we screened a group of TNBC patients (n = 30) of white European descent for mutations...
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2012-01-01
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doaj-d5042e952a864838ab069725a38f88202021-03-04T00:41:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0175e3836110.1371/journal.pone.0038361BRCA2 mutations and triple-negative breast cancer.Peter MeyerKatharina LandgrafBernhard HögelWolfgang EiermannBeyhan AtasevenRecently, BRCA1 germline mutations were found in a high proportion (14-34%) of patients with triple-negative breast cancer (TNBC). BRCA2 was either not analyzed or showed much lower mutation frequencies. Therefore, we screened a group of TNBC patients (n = 30) of white European descent for mutations in BRCA2 as well as in BRCA1. Cases were unselected for age of disease-onset (median age at breast cancer diagnosis was 58 years, ranging from 37 to 74 years), family history of cancer and BRCA1 and BRCA2 mutation status. Half of the patients (15/30) showed a family history of breast and/or ovarian cancer. A high frequency of deleterious germline mutations was observed in BRCA2 (5/30; 16.7%), and only one case showed a BRCA1 mutation (3.3%). Although the study group was small, these results point to BRCA2 mutations being important in TNBC.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22666503/pdf/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Peter Meyer Katharina Landgraf Bernhard Högel Wolfgang Eiermann Beyhan Ataseven |
spellingShingle |
Peter Meyer Katharina Landgraf Bernhard Högel Wolfgang Eiermann Beyhan Ataseven BRCA2 mutations and triple-negative breast cancer. PLoS ONE |
author_facet |
Peter Meyer Katharina Landgraf Bernhard Högel Wolfgang Eiermann Beyhan Ataseven |
author_sort |
Peter Meyer |
title |
BRCA2 mutations and triple-negative breast cancer. |
title_short |
BRCA2 mutations and triple-negative breast cancer. |
title_full |
BRCA2 mutations and triple-negative breast cancer. |
title_fullStr |
BRCA2 mutations and triple-negative breast cancer. |
title_full_unstemmed |
BRCA2 mutations and triple-negative breast cancer. |
title_sort |
brca2 mutations and triple-negative breast cancer. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
Recently, BRCA1 germline mutations were found in a high proportion (14-34%) of patients with triple-negative breast cancer (TNBC). BRCA2 was either not analyzed or showed much lower mutation frequencies. Therefore, we screened a group of TNBC patients (n = 30) of white European descent for mutations in BRCA2 as well as in BRCA1. Cases were unselected for age of disease-onset (median age at breast cancer diagnosis was 58 years, ranging from 37 to 74 years), family history of cancer and BRCA1 and BRCA2 mutation status. Half of the patients (15/30) showed a family history of breast and/or ovarian cancer. A high frequency of deleterious germline mutations was observed in BRCA2 (5/30; 16.7%), and only one case showed a BRCA1 mutation (3.3%). Although the study group was small, these results point to BRCA2 mutations being important in TNBC. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22666503/pdf/?tool=EBI |
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