Patient and physician preferences for ulcerative colitis treatments in the United States
Marco Boeri,1 Kelley Myers,2 Claire Ervin,2 Amy Marren,3 Marco DiBonaventura,4 Joseph C Cappelleri,5 Brett Hauber,2 David T Rubin61RTI Health Solutions, Health Preference Assessment, Belfast, BT2 8LA, UK; 2RTI Health Solutions, Health Preference Assessment, Research Triangle Park, NC, 27709, USA; 3P...
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doaj-d50cbec3c6bf4ff49fb007f4ace2d9682020-11-25T01:34:18ZengDove Medical PressClinical and Experimental Gastroenterology1178-70232019-06-01Volume 1226327846398Patient and physician preferences for ulcerative colitis treatments in the United StatesBoeri MMyers KErvin CMarren ADiBonaventura MCappelleri JCHauber BRubin DTMarco Boeri,1 Kelley Myers,2 Claire Ervin,2 Amy Marren,3 Marco DiBonaventura,4 Joseph C Cappelleri,5 Brett Hauber,2 David T Rubin61RTI Health Solutions, Health Preference Assessment, Belfast, BT2 8LA, UK; 2RTI Health Solutions, Health Preference Assessment, Research Triangle Park, NC, 27709, USA; 3Pfizer, Inflammation and Immunology, Collegeville, PA, 19426, USA; 4Pfizer, Health Economics and Outcomes Research, New York, NY, 10017, USA; 5Pfizer, Global Product Development, Groton, CT, 06340, USA; 6Department of Medicine, Inflammatory Bowel Disease Center, University of Chicago, Chicago, IL 60637, USAPurpose: This study aimed to elicit patient and physician preferences for ulcerative colitis (UC) treatments in the United States (US).Patients and methods: The following UC treatment attributes included in the discrete-choice experiment (DCE) were identified during qualitative interviews with both patients and physicians: time to symptom improvement, chance of long-term symptom control, risks of serious infection and malignancy, mode and frequency of administration, and need for steroids. The DCE survey instruments were developed and administered to patients and physicians. A random-parameters logit model was used to estimate preference weights and conditional relative importance for these attributes.Results: A total of 200 patients with moderate to severe UC (status determined using self-reported medication history) and 200 gastroenterologists completed the survey. Patients’ average age was 42 years; most (59%) were female. Patients considered symptom control 2.5 times as important as time to symptom improvement and 5-year risk of malignancy almost as important as long-term symptom control (relative importance, 0.79 vs 0.96 for long-term symptom control); they preferred oral to subcutaneous or intravenous administration (relative importance, 0.47 vs 0.11 and 0.18, respectively). For physicians, symptom control was the most important attribute and was five times as important as the risk of malignancy.Conclusion: Both patients and physicians considered long-term symptom control the most important attribute relative to others; however, risk of malignancy was of almost-equal importance to patients but not physicians. Differences between patients’ and physicians’ preferences highlight the need for improved communication about the relevant benefits and risks of different UC treatments to improve therapeutic decision-making.Keywords: ulcerative colitis, discrete-choice experiments, maximum acceptable risk, patient preference, physician preference https://www.dovepress.com/patient-and-physician-preferences-for-ulcerative-colitis-treatments-in-peer-reviewed-article-CEG: ulcerative colitisdiscrete-choice experimentsmaximum acceptable riskpatient preferencephysician preference |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Boeri M Myers K Ervin C Marren A DiBonaventura M Cappelleri JC Hauber B Rubin DT |
spellingShingle |
Boeri M Myers K Ervin C Marren A DiBonaventura M Cappelleri JC Hauber B Rubin DT Patient and physician preferences for ulcerative colitis treatments in the United States Clinical and Experimental Gastroenterology : ulcerative colitis discrete-choice experiments maximum acceptable risk patient preference physician preference |
author_facet |
Boeri M Myers K Ervin C Marren A DiBonaventura M Cappelleri JC Hauber B Rubin DT |
author_sort |
Boeri M |
title |
Patient and physician preferences for ulcerative colitis treatments in the United States |
title_short |
Patient and physician preferences for ulcerative colitis treatments in the United States |
title_full |
Patient and physician preferences for ulcerative colitis treatments in the United States |
title_fullStr |
Patient and physician preferences for ulcerative colitis treatments in the United States |
title_full_unstemmed |
Patient and physician preferences for ulcerative colitis treatments in the United States |
title_sort |
patient and physician preferences for ulcerative colitis treatments in the united states |
publisher |
Dove Medical Press |
series |
Clinical and Experimental Gastroenterology |
issn |
1178-7023 |
publishDate |
2019-06-01 |
description |
Marco Boeri,1 Kelley Myers,2 Claire Ervin,2 Amy Marren,3 Marco DiBonaventura,4 Joseph C Cappelleri,5 Brett Hauber,2 David T Rubin61RTI Health Solutions, Health Preference Assessment, Belfast, BT2 8LA, UK; 2RTI Health Solutions, Health Preference Assessment, Research Triangle Park, NC, 27709, USA; 3Pfizer, Inflammation and Immunology, Collegeville, PA, 19426, USA; 4Pfizer, Health Economics and Outcomes Research, New York, NY, 10017, USA; 5Pfizer, Global Product Development, Groton, CT, 06340, USA; 6Department of Medicine, Inflammatory Bowel Disease Center, University of Chicago, Chicago, IL 60637, USAPurpose: This study aimed to elicit patient and physician preferences for ulcerative colitis (UC) treatments in the United States (US).Patients and methods: The following UC treatment attributes included in the discrete-choice experiment (DCE) were identified during qualitative interviews with both patients and physicians: time to symptom improvement, chance of long-term symptom control, risks of serious infection and malignancy, mode and frequency of administration, and need for steroids. The DCE survey instruments were developed and administered to patients and physicians. A random-parameters logit model was used to estimate preference weights and conditional relative importance for these attributes.Results: A total of 200 patients with moderate to severe UC (status determined using self-reported medication history) and 200 gastroenterologists completed the survey. Patients’ average age was 42 years; most (59%) were female. Patients considered symptom control 2.5 times as important as time to symptom improvement and 5-year risk of malignancy almost as important as long-term symptom control (relative importance, 0.79 vs 0.96 for long-term symptom control); they preferred oral to subcutaneous or intravenous administration (relative importance, 0.47 vs 0.11 and 0.18, respectively). For physicians, symptom control was the most important attribute and was five times as important as the risk of malignancy.Conclusion: Both patients and physicians considered long-term symptom control the most important attribute relative to others; however, risk of malignancy was of almost-equal importance to patients but not physicians. Differences between patients’ and physicians’ preferences highlight the need for improved communication about the relevant benefits and risks of different UC treatments to improve therapeutic decision-making.Keywords: ulcerative colitis, discrete-choice experiments, maximum acceptable risk, patient preference, physician preference
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topic |
: ulcerative colitis discrete-choice experiments maximum acceptable risk patient preference physician preference |
url |
https://www.dovepress.com/patient-and-physician-preferences-for-ulcerative-colitis-treatments-in-peer-reviewed-article-CEG |
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